scholarly journals Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Akash Bhattacharya ◽  
Zhonghua Wang ◽  
Tommy White ◽  
Cindy Buffone ◽  
Laura A. Nguyen ◽  
...  
Keyword(s):  
Tetramer Stability

Covalently immobilized catalase on functionalized graphene: effect on the activity, immobilization efficiency, and tetramer stability

2018 ◽  
Vol 6 (12) ◽  
pp. 3231-3240 ◽  
Author(s):  
Davide Barreca ◽  
Giulia Neri ◽  
Angela Scala ◽  
Enza Fazio ◽  
Davide Gentile ◽  
...  
Keyword(s):  
Biological Properties ◽  
Functionalized Graphene ◽  
Immobilized Catalase ◽  
Quaternary Structures ◽  
Covalently Linked ◽  
Tetramer Stability

The different anchorage modes of catalase covalently linked to graphene affect the secondary and quaternary structures determining the biological properties.

scholarly journals Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: Implications to tetramer stability and ligand-binding

2010 ◽  
Vol 170 (3) ◽  
pp. 522-531 ◽  
Author(s):  
Daniela B.B. Trivella ◽  
Lucas Bleicher ◽  
Leonardo de Castro Palmieri ◽  
Helton José Wiggers ◽  
Carlos Alberto Montanari ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Wild Type ◽  
Tetramer Stability

Defective spectrin integrity and neonatal thrombosis in the first mouse model for severe hereditary elliptocytosis

Blood ◽  
2001 ◽  
Vol 97 (2) ◽  
pp. 543-550 ◽  
Author(s):  
Nancy J. Wandersee ◽  
Amanda N. Roesch ◽  
Nancy R. Hamblen ◽  
Joost de Moes ◽  
Martin A. van der Valk ◽  
...  
Keyword(s):  
Hereditary Spherocytosis ◽  
Exon Skipping ◽  
Osmotic Fragility ◽  
Spontaneous Mutant ◽  
Hereditary Elliptocytosis ◽  
Unique Model ◽  
Blood Cell Morphology ◽  
Intracisternal A Particle ◽  
Tetramer Stability ◽  
Deficient Mice

Abstract Mutations affecting the conversion of spectrin dimers to tetramers result in hereditary elliptocytosis (HE), whereas a deficiency of human erythroid α- or β-spectrin results in hereditary spherocytosis (HS). All spontaneous mutant mice with cytoskeletal deficiencies of spectrin reported to date have HS. Here, the first spontaneous mouse mutant,sphDem/ sphDem, with severe HE is described. The sphDem mutation is the insertion of an intracisternal A particle element in intron 10 of the erythroid α-spectrin gene. This causes exon skipping, the in-frame deletion of 46 amino acids from repeat 5 of α-spectrin and alters spectrin dimer/tetramer stability and osmotic fragility. The disease is more severe insphDem/sphDem neonates than in α-spectrin–deficient mice with HS. Thrombosis and infarction are not, as in the HS mice, limited to adults but occur soon after birth. Genetic background differences that exist between HE and HS mice are suspect, along with red blood cell morphology differences, as modifiers of thrombosis timing.sphDem/sphDem mice provide a unique model for analyzing spectrin dimer- to-tetramer conversion and identifying factors that influence thrombosis.

scholarly journals Allosteric Effectors Influence the Tetramer Stability of Both R- and T-states of Hemoglobin A

2006 ◽  
Vol 281 (36) ◽  
pp. 25972-25983 ◽  
Author(s):  
Gusztáv Schay ◽  
László Smeller ◽  
Antonio Tsuneshige ◽  
Takashi Yonetani ◽  
Judit Fidy
Keyword(s):  
Hemoglobin A ◽  
Allosteric Effectors ◽  
Tetramer Stability

Numerical simulation of aldolase tetramer stability

1998 ◽  
Vol 28 (1) ◽  
pp. 67-73 ◽  
Author(s):  
M. Miteva ◽  
E. Alexov ◽  
B. Atanasov
Keyword(s):  
Numerical Simulation ◽  
Tetramer Stability
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