scholarly journals Out-of-Plane Coordinated Porphyrin Nanotubes with Enhanced Singlet Oxygen Generation Efficiency

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Qiang Zhao ◽  
Yao Wang ◽  
Yanshuang Xu ◽  
Yun Yan ◽  
Jianbin Huang
Keyword(s):  
Singlet Oxygen ◽  
Generation Efficiency ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Out Of Plane

Novel BODIPY-Cyclotriphosphazene- Fullerene triads: Synthesis, characterization and singlet oxygen generation efficiency

2018 ◽  
Vol 153 ◽  
pp. 26-34 ◽  
Author(s):  
Semiha Yıldırım Sarıkaya ◽  
Serkan Yeşilot ◽  
Adem Kılıç ◽  
Elif Okutan
Keyword(s):  
Singlet Oxygen ◽  
Generation Efficiency ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

The main strategies for tuning BODIPY fluorophores into photosensitizers

2020 ◽  
Vol 24 (05n07) ◽  
pp. 603-635 ◽  
Author(s):  
Jun Wang ◽  
Qingbao Gong ◽  
Long Wang ◽  
Erhong Hao ◽  
Lijuan Jiao
Keyword(s):  
Singlet Oxygen ◽  
Fluorescent Dyes ◽  
Malignant Tumors ◽  
Therapeutic Agents ◽  
Invasive Technique ◽  
Generation Efficiency ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Cancer Tumor ◽  
Dual Imaging

Photodynamic therapy (PDT) is a minimally invasive technique for the treatment of target malignant tumors via the generation of highly reactive singlet oxygen species. PDT treatment of cancer/tumor tissues greatly relies on the development of suitable stable, highly specific and efficient photosensitizers. BODIPY (Boron dipyrromethene) derivatives, as a class of well-developed, versatile fluorescent dyes, has emerged as a new class of PDT agents over the past decade. Many elegant strategies have been developed to enhance the singlet oxygen generation efficiency and the cancer/tumor cell selectivity of BODIPY-based photosensitizers to improve the therapeutic outcomes as well as to minimize the side effects. Many of the currently reported BODIPY-based photosensitizers are valuable dual imaging and therapeutic agents, which can efficiently generate singlet oxygen for PDT and emit fluorescence for in vivo imaging. Although the currently approved PDT agents used for clinical trials do not feature BODIPYs, this situation is expected to change. In this review, we provide an overview of the various strategies that have been used to improve the singlet oxygen generation efficiency for tuning BODIPY fluorophores into photosensitizers and dual imaging/therapeutic agents. Their photophysical properties and photocytotoxic activity including the absorption/emission wavelengths, the singlet oxygen generation efficiency ([Formula: see text] and the half maximal inhibitory concentration [Formula: see text] of these currently reported photosensitizers are summarized. We believe these newly developed BODIPY-based photosensitizers will broaden current concepts of strategies for PDT agent design, and promise to make an important contribution to the diagnosis and therapeutics for the treatment of cancer.

Competition and regulation between triplet phosphorescence and singlet oxygen generation efficiency

2022 ◽  
pp. 118723
Author(s):  
Lixin Zang ◽  
Huibin Wang ◽  
Zongxue Wang ◽  
Shumin Wang ◽  
Miaomiao Yu ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Generation Efficiency ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

Photophysical properties of sinoporphyrin sodium and explanation of its high photo-activity

2017 ◽  
Vol 21 (01) ◽  
pp. 59-66 ◽  
Author(s):  
Lixin Zang ◽  
Huimin Zhao ◽  
Qicheng Fang ◽  
Ming Fan ◽  
Tong Chen ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Singlet Oxygen ◽  
Extinction Coefficient ◽  
Photophysical Properties ◽  
Generation Efficiency ◽  
High Brightness ◽  
Extinction Coefficients ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Yield Formula

Sinoporphyrin sodium (DVDMS) is a novel photosensitizer with high photodynamic therapy (PDT) effect. Reasons for its high photo-activity were investigated according to the study of photophysical characteristics of DVDMS. Extinction coefficients ([Formula: see text] of DVDMS at 405 nm and 630 nm are 4.36 × 105 and 1.84 × 104 M[Formula: see text].cm[Formula: see text]; fluorescence quantum yield ([Formula: see text] is 0.026; quantum yield of lowest triplet state formation is 0.94 and singlet oxygen quantum yield ([Formula: see text] is 0.92. Although [Formula: see text] of DVDMS is only 10% higher than that of Photofrin[Formula: see text] (0.83), the extinction coefficient of DVDMS at 630 nm is 10-fold greater than that of Photofrin[Formula: see text]. This leads to its higher singlet oxygen generation efficiency ([Formula: see text]. The higher [Formula: see text] of DVDMS can result in an effective reduction of dosage (1/10 of Photofrin[Formula: see text] reaching the same cytotoxic effect as Photofrin[Formula: see text]. Even though [Formula: see text] is approximately equal to that of Photofrin[Formula: see text], brightness ([Formula: see text] of DVDMS is 10-fold greater than that of Photofrin[Formula: see text] because of the 10-fold greater extinction coefficient. Thus, fluorescence diagnosis ability of 0.2 mg/kg DVDMS is comparable to that of 2 mg/kg Photofrin[Formula: see text] used in PDT. Overall, the 10-fold greater extinction coefficients are responsible for the high brightness and singlet oxygen generation efficiency of DVDMS.

Influence of bromine substitution pattern on the singlet oxygen generation efficiency of two-photon absorbing chromophores

2012 ◽  
Vol 10 (31) ◽  
pp. 6275 ◽  
Author(s):  
Pierre-Henri Lanoë ◽  
Thibault Gallavardin ◽  
Aurore Dupin ◽  
Olivier Maury ◽  
Patrice L. Baldeck ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Generation Efficiency ◽  
Substitution Pattern ◽  
Oxygen Generation ◽  
Two Photon ◽  
Singlet Oxygen Generation ◽  
Bromine Substitution
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