scholarly journals Self-assembled targeted nanoparticles based on transferrin-modified eight-arm-polyethylene glycol–dihydroartemisinin conjugate

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Kefeng Liu ◽  
Lin Dai ◽  
Chunxiao Li ◽  
Jing Liu ◽  
Luying Wang ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Targeted Nanoparticles ◽  
Self Assembled

NO prodrug-conjugated, self-assembled, pH-responsive and galactose receptor targeted nanoparticles for co-delivery of nitric oxide and doxorubicin

Nanoscale ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 4179-4188 ◽  
Author(s):  
Jimin Zhang ◽  
Huijuan Song ◽  
Shenglu Ji ◽  
Xiaomin Wang ◽  
Pingsheng Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Ph Responsive ◽  
Targeted Nanoparticles ◽  
Self Assembled

Nitric oxide (NO) prodrug-conjugated, acid-responsive and galactose receptor targeted nanoparticles were developed for the co-delivery of NO and doxorubicin.

Self-assembled Supramolecular Nanomicelles from Bile Acid-Docetaxel Conjugate are Highly Tolerable with Improved Therapeutic Efficacy

2021 ◽  
Author(s):  
Vedagopuram Sreekanth ◽  
Sanjay Pal ◽  
Sandeep Kumar ◽  
Varsha Komalla ◽  
Poonam Yadav ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Bile Acid ◽  
Therapeutic Efficacy ◽  
Lithocholic Acid ◽  
Self Assembled

Herein, we present the engineering of a supramolecular nanomicellar system that is composed of self-assembled units of PEGylated lithocholic acid (LCA)-Docetaxel (DTX) conjugate (LCA-DTX-PEG). We tethered a short polyethylene glycol...

Norepinephrine transporter analog benzylguanidine-conjugated nanoparticles for the delivery of paclitaxel in neuroblastoma

Nanomedicine ◽  
2021 ◽  
Author(s):  
Ozlem Ozen Karakus ◽  
Kavitha Godugu ◽  
Taher Salaheldin ◽  
Kazutoshi Fujioka ◽  
Shaker A Mousa
Keyword(s):  
Polyethylene Glycol ◽  
Targeted Delivery ◽  
Chemotherapeutic Agent ◽  
Norepinephrine Transporter ◽  
Neuroendocrine Cells ◽  
Safe Delivery ◽  
Targeted Nanoparticles ◽  
Chemotherapy Agent ◽  
Neuroblastoma Tumor ◽  
Targeted Agent

Aim: We previously synthesized a polyethylene glycol-based norepinephrine transporter-targeted agent, BG-P-TAT, which has a benzylguanidine and a triazolyl-tetrac group. This targeted conjugate showed suppression of neuroblastoma tumor progression. In this study we aimed to synthesize nanoparticles to encapsulate the chemotherapeutic agent paclitaxel for targeting neuroblastoma tumors by using benzylguanidine so that it can compete with norepinephrine for uptake by neuroendocrine cells. Methods: Biocompatible poly(lactide-co-glycolic acid)-polyethylene glycol was chosen to prepare targeted nanoparticles for safe delivery of the chemotherapy agent paclitaxel. Result: Paclitaxel concentration was 60% higher in neuroblastoma tumors of mice treated with paclitaxel encapsulated in targeted nanoparticles than with non-targeted nanoparticles. Conclusion: These findings support the targeted delivery of paclitaxel as a chemotherapeutic agent for neuroblastoma.

Curcumin loaded selenium nanoparticles synergize the anticancer potential of doxorubicin contained in self-assembled, cell receptor targeted nanoparticles

2018 ◽  
Vol 130 ◽  
pp. 185-199 ◽  
Author(s):  
Manisha Kumari ◽  
Mahaveer Prasad Purohit ◽  
Satyakam Patnaik ◽  
Yogeshwer Shukla ◽  
Pradeep Kumar ◽  
...  
Keyword(s):  
Cell Receptor ◽  
Selenium Nanoparticles ◽  
Targeted Nanoparticles ◽  
Self Assembled

scholarly journals Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers

2008 ◽  
Vol 105 (7) ◽  
pp. 2586-2591 ◽  
Author(s):  
F. Gu ◽  
L. Zhang ◽  
B. A. Teply ◽  
N. Mann ◽  
A. Wang ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Targeted Nanoparticles ◽  
Self Assembled

Synthesis of AIE polyethylene glycol-block-polypeptide bioconjugates and cell uptake assessments of their self-assembled nanoparticles

2019 ◽  
Vol 170 ◽  
pp. 107640 ◽  
Author(s):  
Mingguang Yu ◽  
Songjing Zhong ◽  
Yusi Quan ◽  
Houhe Liu ◽  
Junyang Zhong ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Cell Uptake ◽  
Self Assembled
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