scholarly journals 3,6-dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Junli Chen ◽  
Hui Chang ◽  
Xiaoli Peng ◽  
Yeyun Gu ◽  
Long Yi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Notch Signaling ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Breast Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Notch Signaling Pathway ◽  
Mesenchymal Transition

3-O-(E)-p-Coumaroyl betulinic acid possess anticancer activity and inhibit Notch signaling pathway in breast cancer cells and mammosphere

2020 ◽  
Vol 328 ◽  
pp. 109200
Author(s):  
Prem Prakash Kushwaha ◽  
Atul Kumar Singh ◽  
Mohd Shuaib ◽  
Kumari Sunita Prajapati ◽  
Pothabathula Seshu Vardhan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Notch Signaling ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Betulinic Acid ◽  
Breast Cancer Cells ◽  
Notch Signaling Pathway

scholarly journals EGF induces epithelial-mesenchymal transition through phospho-Smad2/3-Snail signaling pathway in breast cancer cells

Oncotarget ◽  
2016 ◽  
Vol 7 (51) ◽  
pp. 85021-85032 ◽  
Author(s):  
Jinkyoung Kim ◽  
Jienan Kong ◽  
Hyeyoon Chang ◽  
Hayeon Kim ◽  
Aeree Kim
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Breast Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition

scholarly journals 6-Shogaol suppresses the growth of breast cancer cells by inducing apoptosis and suppressing autophagy via targeting notch signaling pathway

2020 ◽  
Vol 128 ◽  
pp. 110302 ◽  
Author(s):  
Azizah S. Bawadood ◽  
Fahad A. Al-Abbasi ◽  
Firoz Anwar ◽  
Ali M. El-Halawany ◽  
Ahmed M. Al-Abd
Keyword(s):  
Breast Cancer ◽  
Notch Signaling ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Breast Cancer Cells ◽  
Notch Signaling Pathway

scholarly journals Linc00514 promotes breast cancer metastasis and M2 polarization of tumor-associated macrophages via Jagged1-mediated notch signaling pathway

2020 ◽  
Vol 39 (1) ◽  
Author(s):  
Sifeng Tao ◽  
Qiang Chen ◽  
Chen Lin ◽  
Haiying Dong
Keyword(s):  
Breast Cancer ◽  
Notch Signaling ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Breast Cancer Cells ◽  
Cancer Metastasis ◽  
Notch Signaling Pathway ◽  
M2 Macrophage ◽  
M2 Polarization

Abstract Background Tumor-associated macrophages (TAMs) and tumor cells are important components of the tumor microenvironment. M2 polarization of TAMs, which is a major actor in breast cancer malignancy and metastasis, can be induced by breast cancer cells. However, the potential mechanisms of the interaction between breast cancer cells and TAMs remain unclear. Methods The candidate breast cancer-associated long non-coding RNAs (lncRNAs) were analyzed using the GEO database. Functional assays, including MTT assay, Transwell assay, and EdU labeling detection, were performed to investigate the oncogenic role of linc00514 in breast cancer progression. The co-culture and ELISA assays were used to assess the role of linc00514 in macrophage recruitment and M2 polarization. RNA immunoprecipitation, RNA pull-down, and luciferase reporter assays were applied to determine the mechanism of linc00514 in breast cancer metastasis. Mouse xenograft models, mouse pulmonary metastatic models, and mouse primary tumor models were used to assess the role of linc00514 in M2 macrophage polarization and breast cancer tumorigenicity. Results Linc00514 was highly expressed in clinical breast cancer tissues and breast cancer cell lines. Overexpression of linc00514 promoted the proliferation and invasion of breast cancer cells and increased xenograft tumor volumes and pulmonary metastatic nodules. Overexpression of linc00514 also increased the percentage of macrophages expressing M2 markers CD206 and CD163. Mechanistically, linc00514 promoted Jagged1 expression in a transcriptional manner by increasing the phosphorylation of a transcription factor STAT3. Subsequently, Jagged1-mediated Notch signaling pathway promoted IL-4 and IL-6 secretions in breast cancer cells and ultimately inducing M2 polarization of macrophages. Conclusion Linc00514 plays an important role in regulating breast cancer tumorigenicity and M2 macrophage polarization via Jagged1-mediated Notch signaling pathway.

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