scholarly journals Maximal mid-expiratory flow is a surrogate marker of lung clearance index for assessment of adults with bronchiectasis

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Wei-jie Guan ◽  
Jing-jing Yuan ◽  
Yong-hua Gao ◽  
Hui-min Li ◽  
Jin-ping Zheng ◽  
...  
Keyword(s):  
Surrogate Marker ◽  
Lung Clearance ◽  
Lung Clearance Index ◽  
Expiratory Flow

Der Lung Clearance Index ist bei Patienten mit COPD erhöht

Pneumologie ◽  
2015 ◽  
Vol 69 (S 01) ◽  
Author(s):  
S Fähndrich ◽  
M Seibert ◽  
C Buess ◽  
PM Lepper ◽  
H Wilkens ◽  
...  
Keyword(s):  
Lung Clearance ◽  
Lung Clearance Index

scholarly journals Ventilation heterogeneity in children with severe asthma

2021 ◽  
Author(s):  
Amy G. Nuttall ◽  
Caroline S. Beardsmore ◽  
Erol A. Gaillard
Keyword(s):  
Severe Asthma ◽  
Airway Disease ◽  
Asthma Severity ◽  
Small Airway ◽  
Cross Sectional ◽  
Lung Clearance ◽  
Moderate Asthma ◽  
Lung Clearance Index ◽  
Children With Asthma ◽  
Ventilation Heterogeneity

AbstractSmall airway disease, characterised by ventilation heterogeneity (VH), is present in a subgroup of patients with asthma. Ventilation heterogeneity can be measured using multiple breath washout testing. Few studies have been reported in children. We studied the relationship between VH, asthma severity, and spirometry in a cross-sectional observational cohort study involving children with stable mild-moderate and severe asthma by GINA classification and a group of healthy controls. Thirty-seven participants aged 5–16 years completed multiple breath nitrogen washout (MBNW) testing (seven controls, seven mild-moderate asthma, 23 severe asthma). The lung clearance index (LCI) was normal in control and mild-moderate asthmatics. LCI was abnormal in 5/23 (21%) of severe asthmatics. The LCI negatively correlated with FEV1z-score.Conclusion: VH is present in asthmatic children and appears to be more common in severe asthma. The LCI was significantly higher in the cohort of children with severe asthma, despite no difference in FEV1 between the groups. This supports previous evidence that LCI is a more sensitive marker of airway disease than FEV1. MBNW shows potential as a useful tool to assess children with severe asthma and may help inform clinical decisions. What is Known:• Increased ventilation heterogeneity is present in some children with asthma• Spirometry is not sensitive enough to detect small airway involvement in asthma What is New• Lung clearance index is abnormal in a significant subgroup of children with severe asthma but rarely in children with mild-moderate asthma• Our data suggests that LCI monitoring should be considered in children with severe asthma

scholarly journals P82 Lung clearance index (LCI) and genotype-phenotype correlations in Primary Ciliary Dyskinesia (PCD)

Thorax ◽  
2015 ◽  
Vol 70 (Suppl 3) ◽  
pp. A116.2-A117
Author(s):  
S Irving ◽  
M Dixon ◽  
S Ollosson ◽  
C Hogg ◽  
A Shoemark ◽  
...  
Keyword(s):  
Primary Ciliary Dyskinesia ◽  
Lung Clearance ◽  
Lung Clearance Index ◽  
Ciliary Dyskinesia

scholarly journals WS19.4 Predictors of long term changes in lung clearance index in children with CF

2017 ◽  
Vol 16 ◽  
pp. S33
Author(s):  
F. Vermeulen ◽  
M. Boon ◽  
M. Proesmans ◽  
K. De Boeck
Keyword(s):  
Lung Clearance ◽  
Long Term Changes ◽  
Lung Clearance Index

scholarly journals Lung Clearance Index (LCI) is Stable in Most Primary Ciliary Dyskinesia (PCD) Patients Managed in a Specialist Centre: a Pilot Study

Lung ◽  
2017 ◽  
Vol 195 (4) ◽  
pp. 441-443 ◽  
Author(s):  
S. Irving ◽  
S. Carr ◽  
C. Hogg ◽  
M. Loebinger ◽  
A. Shoemark ◽  
...  
Keyword(s):  
Pilot Study ◽  
Primary Ciliary Dyskinesia ◽  
Lung Clearance ◽  
Lung Clearance Index ◽  
Specialist Centre ◽  
Ciliary Dyskinesia

scholarly journals Patterns of regional lung physiology in cystic fibrosis using ventilation magnetic resonance imaging and multiple-breath washout

2018 ◽  
Vol 52 (5) ◽  
pp. 1800821 ◽  
Author(s):  
Laurie J. Smith ◽  
Guilhem J. Collier ◽  
Helen Marshall ◽  
Paul J.C. Hughes ◽  
Alberto M. Biancardi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cystic Fibrosis ◽  
Total Lung Capacity ◽  
Resonance Imaging ◽  
Ventilation Distribution ◽  
Lung Clearance ◽  
Lung Capacity ◽  
Lung Clearance Index ◽  
Ventilation Heterogeneity ◽  
Multiple Breath Washout

Hyperpolarised helium-3 (3He) ventilation magnetic resonance imaging (MRI) and multiple-breath washout (MBW) are sensitive methods for detecting lung disease in cystic fibrosis (CF). We aimed to explore their relationship across a broad range of CF disease severity and patient age, as well as assess the effect of inhaled lung volume on ventilation distribution.32 children and adults with CF underwent MBW and 3He-MRI at a lung volume of end-inspiratory tidal volume (EIVT). In addition, 28 patients performed 3He-MRI at total lung capacity. 3He-MRI scans were quantitatively analysed for ventilation defect percentage (VDP), ventilation heterogeneity index (VHI) and the number and size of individual contiguous ventilation defects. From MBW, the lung clearance index, convection-dependent ventilation heterogeneity (Scond) and convection–diffusion-dependent ventilation heterogeneity (Sacin) were calculated.VDP and VHI at EIVT strongly correlated with lung clearance index (r=0.89 and r=0.88, respectively), Sacin (r=0.84 and r=0.82, respectively) and forced expiratory volume in 1 s (FEV1) (r=−0.79 and r=−0.78, respectively). Two distinct 3He-MRI patterns were highlighted: patients with abnormal FEV1 had significantly (p<0.001) larger, but fewer, contiguous defects than those with normal FEV1, who tended to have numerous small volume defects. These two MRI patterns were delineated by a VDP of ∼10%. At total lung capacity, when compared to EIVT, VDP and VHI reduced in all subjects (p<0.001), demonstrating improved ventilation distribution and regions of volume-reversible and nonreversible ventilation abnormalities.

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