scholarly journals Elimination of a ligand gating site generates a supersensitive olfactory receptor

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Kanika Sharma ◽  
Gaurav Ahuja ◽  
Ashiq Hussain ◽  
Sabine Balfanz ◽  
Arnd Baumann ◽  
...  
Keyword(s):  
Olfactory Receptor ◽  
Ligand Gating

scholarly journals Full rescue of an inactive olfactory receptor mutant by elimination of an allosteric ligand-gating site

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Kanika Sharma ◽  
Sabine Balfanz ◽  
Arnd Baumann ◽  
Sigrun Korsching
Keyword(s):  
Olfactory Receptor ◽  
Ligand Gating ◽  
Receptor Mutant

Ultrastructural aspects of olfactory signal transduction and its development

1994 ◽  
Vol 52 ◽  
pp. 142-143
Author(s):  
Bert Ph. M. Menco
Keyword(s):  
Signal Transduction ◽  
Olfactory Receptor ◽  
Receptor Cell ◽  
Freeze Substitution ◽  
Luminal Surface ◽  
Tissue Sections ◽  
Olfactory Receptor Cells ◽  
Receptor Cells ◽  
Olfactory Signal ◽  
Odor Molecule

Vertebrate olfactory receptor cells are specialized neurons that have numerous long tapering cilia. The distal parts of these cilia line the interface between the external odorous environment and the luminal surface of the olfactory epithelium. The length and number of these cilia results in a large surface area that presumably increases the chance that an odor molecule will meet a receptor cell. Advanced methods of cryoprepration and immuno-gold labeling were particularly useful to preserve the delicate ultrastructural and immunocytochemical features of olfactory cilia required for localization of molecules involved in olfactory signal-transduction. We subjected olfactory tissues to freeze-substitution in acetone (unfixed tissues) or methanol (fixed tissues) followed by low temperature embedding in Lowicryl K11M for that purpose. Tissue sections were immunoreacted with several antibodies against proteins that are presumably important in olfactory signal-transduction.

Function of the olfactory receptor OR2AT4 in alveolar macrophages

2020 ◽  
Author(s):  
D Weidinger ◽  
D Alisch ◽  
K Jamal Jameel ◽  
M Ruhe ◽  
F Yusuf ◽  
...  
Keyword(s):  
Alveolar Macrophages ◽  
Olfactory Receptor
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