scholarly journals Water-soluble benzylidene cyclopentanone based photosensitizers for in vitro and in vivo antimicrobial photodynamic therapy

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yanyan Fang ◽  
Tianlong Liu ◽  
Qianli Zou ◽  
Yuxia Zhao ◽  
Feipeng Wu
Keyword(s):  
Photodynamic Therapy ◽  
Water Soluble ◽  
Antimicrobial Photodynamic Therapy

scholarly journals Antimicrobial Photodynamic Therapy and Dental Plaque: A Systematic Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
G. C. Santin ◽  
D. S. B. Oliveira ◽  
R. Galo ◽  
M. C. Borsatto ◽  
S. A. M. Corona
Keyword(s):  
Systematic Review ◽  
Photodynamic Therapy ◽  
Data Extraction ◽  
Antimicrobial Photodynamic Therapy ◽  
Review Of The Literature ◽  
Eligibility Criteria ◽  
Dental Biofilm ◽  
Quality Assessments

Background. The aim of this study was to perform a systematic review of the literature on the efficacy of antimicrobial photodynamic therapy (PDTa) on cariogenic dental biofilm.Types of Studies Reviewed. Studiesin vivo,in vitro, andin situwere included. Articles that did not address PDTa, those that did not involve cariogenic biofilm, those that used microorganisms in the plankton phase, and reviews were excluded. Data extraction and quality assessments were performed independently by two raters using a scale.Results. Two hundred forty articles were retrieved; only seventeen of them met the eligibility criteria and were analyzed in the present review. Considerable variability was found regarding the methodologies and application protocols for antimicrobial PDTa. Two articles reported unfavorable results.Practical Implications. The present systematic review does not allow drawing any concrete conclusions regarding the efficacy of antimicrobial PDTa, although this method seems to be a promising option.

Antimicrobial photodynamic therapy in chronic osteomyelitis induced by Staphylococcus aureus: An in vitro and in vivo study

2012 ◽  
Author(s):  
João Alves dos Reis Júnior ◽  
Patrícia Nascimento de Assis ◽  
Garde^nia Matos Paraguassú ◽  
Isabele Cardoso Vieira de de Castro ◽  
Renan Ferreira Trindade ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Chronic Osteomyelitis ◽  
In Vivo Study ◽  
Antimicrobial Photodynamic Therapy

scholarly journals Antimicrobial photodynamic therapy with fulleropyrrolidine: photoinactivation mechanism of Staphylococcus aureus, in vitro and in vivo studies

2015 ◽  
Vol 99 (9) ◽  
pp. 4031-4043 ◽  
Author(s):  
Mariusz Grinholc ◽  
Joanna Nakonieczna ◽  
Grzegorz Fila ◽  
Aleksandra Taraszkiewicz ◽  
Anna Kawiak ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
In Vivo Studies ◽  
Antimicrobial Photodynamic Therapy

scholarly journals Antimicrobial Photodynamic Therapy Combined With Antibiotic in the Treatment of Rats With Third-Degree Burns

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhanjuan Zhao ◽  
Jinduo Ma ◽  
Yiyi Wang ◽  
Zehua Xu ◽  
Lu Zhao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Antibiotic Treatment ◽  
Bacterial Species ◽  
The Other ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Antimicrobial Photodynamic Therapy ◽  
Wound Tissue

Cationic porphyrin conjugate, protoporphyrin IX-methyl ethylenediamine derivative (PPIX-MED) has a potent photosensitive antibacterial effect on clinically isolated bacteria, including methicillin-resistant Staphylococcus aureus, (MRSA), Escherichia coli, and Pseudomonas aeruginosa. This study investigated (i) the PPIX-MED-mediated antimicrobial photodynamic effect on these three species in vitro and (ii) the effect of antimicrobial photodynamic therapy (aPDT) combined with the use of an antibiotic on the healing in vivo of third-degree burns of rats with the wounds infected by these bacterial species. PPIX-MED exerted a potent inhibitory effect on the growth of the three bacterial species by producing reactive oxygen species when photoactivated. PPIX-MED-mediated antimicrobial photodynamic therapy (PPIX-MED-aPDT) had high bacterial photoinactivation ability in vitro, with a minimum inhibitory concentration of 15.6 μM PPIX-MED against each of the three types of bacteria and minimum bactericidal concentrations of 31.25 μM against MRSA and E. coli and 62.5 μM against P. aeruginosa. In rats with third-degree burns infected by a mixture of these bacteria, the bactericidal efficiency of PPIX-MED–aPDT-combined-with-antibiotic treatment was higher than that of antibiotic or aPDT treatment alone. This was confirmed by analysis of viable bacterial counts in wound tissue and blood. Enzyme-linked immunosorbent assay revealed that aPDT-combined-with-antibiotic treatment resulted in an obvious reduction in tumor necrosis factor-alpha and interleukin-6 levels compared with the no-treatment control group and the other treatment groups. Immunohistochemistry revealed that the expression of basic fibroblast growth factor and CD31 (a marker of neovascularization), expressed in burn wound tissue was higher in the aPDT-combined-with-antibiotic treatment group than in the other groups. PPIX-MED–aPDT has a promising bactericidal effect both in vitro and in vivo, and PPIX-MED–aPDT-combined-with-antibiotic treatment enhanced the healing of infected third-degree burns in rats.

Self-assembly nanoparticles based on supramolecular-organic frameworks and temoporfin for an enhanced photodynamic therapy in vitro and in vivo

2022 ◽  
Author(s):  
Ziyue Xu ◽  
Weipeng Mao ◽  
Zizhen Zhao ◽  
Zekun Wang ◽  
Yue-Yang Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Three Dimensional ◽  
Water Soluble ◽  
Generation Efficiency ◽  
Quenching Effect

Water-soluble three-dimensional supramolecular-organic frameworks (SOFs) and temoporfin (mTHPC) are discovered to form uniform self-assembly nanoparticles. These nanoparticles demonstrate an improved 1O2 generation efficiency due to a reduced aggregation-caused quenching effect....

scholarly journals Antimicrobial photodynamic therapy fighting polymicrobial infections – a journey from in vitro to in vivo

2020 ◽  
Vol 19 (10) ◽  
pp. 1332-1343
Author(s):  
Lisa Karner ◽  
Susanne Drechsler ◽  
Magdalena Metzger ◽  
Ara Hacobian ◽  
Barbara Schädl ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Bacterial Suspension ◽  
Antimicrobial Photodynamic Therapy ◽  
Led Light ◽  
Wound Model ◽  
Red Led ◽  
Polymicrobial Infections

The batericidal effects of antimicrobial photodynamic therapy (aPDT), using methylene blue as a photosensitizer and pulsed red LED light for activation, were tested in various environments in vitro and in a wound model in mice infected with a fecal bacterial suspension.

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