scholarly journals The impact of genotype calling errors on family-based studies

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Qi Yan ◽  
Rui Chen ◽  
James S. Sutcliffe ◽  
Edwin H. Cook ◽  
Daniel E. Weeks ◽  
...  
2001 ◽  
Vol 9 (2) ◽  
pp. 130-134 ◽  
Author(s):  
Gonçalo R Abecasis ◽  
Stacey S Cherny ◽  
Lon R Cardon

2008 ◽  
Author(s):  
Ruby Ann Natale ◽  
Sarah Messiah ◽  
Jennifer Barth ◽  
Gabriela Lopez-Mitnik ◽  
Lee Sanders

Author(s):  
Mark Savill

Current best practice regarding the treatment of negative symptoms of schizophrenia supports the use of psychological interventions in addition to medication. This chapter reviews the literature evaluating different non-pharmacological approaches to treating these symptoms. Meta-analytic studies suggest that social skills training, music therapy, non-invasive brain stimulation, mindfulness, and exercise-based interventions are all effective at improving negative symptoms, relative to treatment as usual (TAU). Effect sizes for these interventions range from small to moderate. The long-term benefits of these interventions are currently unclear, and there has been some debate as to whether the impact of these interventions constitute consistent, clinically meaningful change. Evidence for other therapies such as arts therapies other than music therapy, cognitive behavioural therapies for psychosis, neurocognitive therapies, and family-based interventions is more inconsistent. As a result, primary negative symptoms of schizophrenia can still be considered an important unmet therapeutic need where more research is needed.


2019 ◽  
Vol 140 (3) ◽  
pp. 148-152
Author(s):  
RC Povey ◽  
LJ Cowap ◽  
K Scholtens ◽  
MJ Forshaw

Aims: To discover the reasons behind invited families’ lack of engagement with a family-based childhood obesity programme in a deprived area. Methods: Interviews were conducted with 10 families who were invited to join the programme, but declined to engage. There were two distinct subgroups of participants: those who had no interest in attending the programme and those who showed initial interest yet did not continue attending. The two subgroups were analyzed separately using inductive thematic analysis, and then compared. Results: Analysis identified eight themes overall. For both groups, when the service was perceived to be not needed (‘I didn’t see how that would help’), the families disengaged with it. For both groups, this perception was partly related to the perceived appearance of their children: either that they were not obese (‘I didn’t think my son was overweight’) or that they were growing into their size. There was also a similarity in both groups that they perceived that they were already following healthy lifestyles. In addition, several of the themes arising from the families who had no initial interest were related to the impact of the letter that parents received detailing the result of their child being weighed and measured at school. This angered parents (‘I was disgusted’), and there was a feeling that the approach was too generic. Conclusion: This study identified a number of potential reasons behind why families may decline to engage with a childhood obesity programme in a deprived area. Across all families, if the programme was perceived as not needed, they would disengage. For those who did not engage at all, the initial communication of the child’s body mass index (BMI) is crucial. Recommendations include taking a more personal and tailored approach for the initial communication and shifting the focus of the programmes onto healthier lifestyles.


2010 ◽  
Vol 42 (3) ◽  
pp. 587-614 ◽  
Author(s):  
BRYAN R. ROBERTS

AbstractThis paper focuses on the similarities and differences between contemporary urban organisation and that of the 1960s in Guatemala City and other Latin American cities, mainly using data taken from a re-study of low-income neighbourhoods in Guatemala City. It looks at the impact of sharper patterns of residential segregation, changes in migration patterns, rising levels of crime and violence, and the increase in the relationships of the urban poor with external actors, such as governments and NGOs. Severe inequality persists, but is mediated by an improvement in living standards, by the range of consumer goods accessible to the poor, and by community- and family-based adaptation.


1986 ◽  
Vol 148 (3) ◽  
pp. 279-287 ◽  
Author(s):  
Jeri A. Doane ◽  
Michael J. Goldstein ◽  
David J. Miklowitz ◽  
Ian R. H. Falloon

Measures of parental affective style were compared for families of schizophrenics participating in a controlled treatment study which contrasted individual and family-based therapeutic programmes. The total number of critical statements and non-critical, intrusive remarks was significantly lower after three months for parents of schizophrenics participating in family therapy, compared to those whose offspring received only individual therapy. An increased risk for relapse was associated with an increase in the number of critical and/or intrusive remarks for patients in individual treatment. A significant increase in non-emotional, problem-solving statements was observed in parents who received family therapy, compared with those who did not. The results suggest that a behaviourally-oriented, problem-solving family approach may have reduced the risk of relapse in the first nine months after discharge from hospital by teaching families concrete ways of solving problems and concomitantly reducing the amount of negative emotional relating between family members.


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