scholarly journals Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Arvinder Kapur ◽  
Mildred Felder ◽  
Lucas Fass ◽  
Justanjot Kaur ◽  
Austin Czarnecki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Proliferation ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Induction Of Apoptosis

scholarly journals NRF2-mediated signaling is a master regulator of transcription factors in bovine granulosa cells under oxidative stress condition

2021 ◽  
Author(s):  
Mohamed Omar Taqi ◽  
Mohammed Saeed-Zidane ◽  
Samuel Gebremedhn ◽  
Dessie Salilew-Wondim ◽  
Ernst Tholen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Proliferation ◽  
Endoplasmic Reticulum ◽  
Transcription Factors ◽  
Endoplasmic Reticulum Stress ◽  
Granulosa Cells ◽  
Mitochondrial Activity ◽  
Small Interference Rna ◽  
Nrf2 Signaling Pathway

AbstractTranscription factors (TFs) are known to be involved in regulating the expression of several classes of genes during folliculogenesis. However, the regulatory role of TFs during oxidative stress (OS) is not fully understood. The current study was aimed to investigate the regulation of the TFs in bovine granulosa cells (bGCs) during exposure to OS induced by H2O2 in vitro. For this, bGCs derived from ovarian follicles were cultured in vitro till their confluency and then treated with H2O2 for 40 min. Twenty-four hours later, cells were subjected to various phenotypic and gene expression analyses for genes related to TFs, endoplasmic reticulum stress, apoptosis, cell proliferation, and differentiation markers. The bGCs exhibited higher reactive oxygen species accumulation, DNA fragmentation, and endoplasmic reticulum stress accompanied by reduction of mitochondrial activity after exposure to OS. In addition, higher lipid accumulation and lower cell proliferation were noticed in H2O2-challenged cells. The mRNA level of TFs including NRF2, E2F1, KLF6, KLF9, FOS, SREBF1, SREBF2, and NOTCH1 was increased in H2O2-treated cells compared with non-treated controls. However, the expression level of KLF4 and its downstream gene, CCNB1, were downregulated in the H2O2-challenged group. Moreover, targeted inhibition of NRF2 using small interference RNA resulted in reduced expression of KLF9, FOS, SREBF2, and NOTCH1 genes, while the expression of KLF4 was upregulated. Taken together, bovine granulosa cells exposed to OS exhibited differential expression of various transcription factors, which are mediated by the NRF2 signaling pathway.

A green chemistry approach for the synthesis of gold nanoconjugates that induce the inhibition of cancer cell proliferation through induction of oxidative stress and their in vivo toxicity study

2015 ◽  
Vol 3 (18) ◽  
pp. 3820-3830 ◽  
Author(s):  
Sudip Mukherjee ◽  
Mamatha Dasari ◽  
Sumahitha Priyamvada ◽  
Rajesh Kotcherlakota ◽  
Vishnu Sravan Bollu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Proliferation ◽  
Gold Nanoparticles ◽  
Green Chemistry ◽  
Cancer Cell ◽  
Cancer Therapeutics ◽  
Toxicity Study ◽  
Cancer Cell Proliferation ◽  
Near Future

The synthesis and fabrication of green chemistry based biocompatible gold nanoparticles could be clinically effective towards cancer therapeutics in the near future.

Effects of Lactobacillus strains on cancer cell proliferation and oxidative stress in vitro

2006 ◽  
Vol 42 (5) ◽  
pp. 452-458 ◽  
Author(s):  
S.S. Choi ◽  
Y. Kim ◽  
K.S. Han ◽  
S. You ◽  
S. Oh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Cancer Cell Proliferation ◽  
And Oxidative Stress
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