scholarly journals Dengue Specific Immunoglobulin A Antibody is Present in Urine and Associated with Disease Severity

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Hui Zhao ◽  
Shuang Qiu ◽  
Wen-Xin Hong ◽  
Ke-Yu Song ◽  
Jian Wang ◽  
...  
Keyword(s):  
Disease Severity ◽  
Immunoglobulin A ◽  
Specific Immunoglobulin

scholarly journals Salivary human immunodeficiency virus (HIV)-1-specific immunoglobulin A in HIV-1-exposed infants in Kenya

2008 ◽  
Vol 153 (1) ◽  
pp. 37-43 ◽  
Author(s):  
C. Farquhar ◽  
T. VanCott ◽  
R. Bosire ◽  
C. Bermudez ◽  
D. Mbori-Ngacha ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Immunoglobulin A ◽  
Immunodeficiency Virus ◽  
Specific Immunoglobulin ◽  
Hiv 1

Poliovirus-specific immunoglobulin A in persons vaccinated with inactivated poliovirus vaccine in The Netherlands.

1997 ◽  
Vol 4 (5) ◽  
pp. 499-503 ◽  
Author(s):  
M M Herremans ◽  
A M van Loon ◽  
J H Reimerink ◽  
H C Rümke ◽  
H G van der Avoort ◽  
...  
Keyword(s):  
The Netherlands ◽  
Immunoglobulin A ◽  
Specific Immunoglobulin

scholarly journals Norovirus-specific immunoglobulin A in breast milk for protection against norovirus-associated diarrhea among infants

2020 ◽  
Vol 27 ◽  
pp. 100561
Author(s):  
Hannah Karen Mina Labayo ◽  
Monica J. Pajuelo ◽  
Kentaro Tohma ◽  
Lauren A. Ford-Siltz ◽  
Robert H. Gilman ◽  
...  
Keyword(s):  
Breast Milk ◽  
Immunoglobulin A ◽  
Specific Immunoglobulin

Elevated levels of total and dengue virus-specific immunoglobulin E in patients with varying disease severity

2003 ◽  
Vol 70 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Penelopie Koraka ◽  
Bernadette Murgue ◽  
Xavier Deparis ◽  
Tatty E. Setiati ◽  
Catarina Suharti ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Disease Severity ◽  
Immunoglobulin E ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin

scholarly journals Hepatitis A Virus-Specific Immunoglobulin A Mediates Infection of Hepatocytes with Hepatitis A Virus via the Asialoglycoprotein Receptor

2000 ◽  
Vol 74 (23) ◽  
pp. 10950-10957 ◽  
Author(s):  
Andreas Dotzauer ◽  
Ulrike Gebhardt ◽  
Karen Bieback ◽  
Ulrich Göttke ◽  
Anja Kracke ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Neutralizing Antibodies ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Immunoglobulin A ◽  
Asialoglycoprotein Receptor ◽  
Primary Hepatocytes ◽  
Mouse Hepatocyte ◽  
Specific Immunoglobulin ◽  
Bile Fluid

ABSTRACT The mechanisms underlying the hepatotropism of hepatitis A virus (HAV) and the relapsing courses of HAV infections are unknown. In this report, we show for a mouse hepatocyte model that HAV-specific immunoglobulin A (IgA) mediates infection of hepatocytes with HAV via the asialoglycoprotein receptor, which binds and internalizes IgA molecules. Proof of HAV infection was obtained by detection of HAV minus-strand RNA, which is indicative for virus replication, and quantification of infectious virions. We demonstrate that human hepatocytes also ingest HAV–anti-HAV IgA complexes by the same mechanism, resulting in infection of the cells, by using the HepG2 cell line and primary hepatocytes. The relevance of this surrogate receptor mechanism in HAV pathogenesis lies in the fact that HAV, IgA, and antigen-IgA complexes use the same pathway within the organism, leading from the gastrointestinal tract to the liver via blood and back to the gastrointestinal tract via bile fluid. Therefore, HAV-specific IgA antibodies produced by gastrointestinal mucosa-associated lymphoid tissue may serve as carrier and targeting molecules, enabling and supporting HAV infection of IgA receptor-positive hepatocytes and, in the case of relapsing courses, allowing reinfection of the liver in the presence of otherwise neutralizing antibodies, resulting in exacerbation of liver disease.

scholarly journals Specific Immunoglobulin A Antibodies in Maternal Milk and Delayed Helicobacter pylori Colonization in Gambian Infants

2004 ◽  
Vol 39 (8) ◽  
pp. 1155-1160 ◽  
Author(s):  
J. E. Thomas ◽  
J. E. G. Bunn ◽  
H. Kleanthous ◽  
T. P. Monath ◽  
M. Harding ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Immunoglobulin A ◽  
Maternal Milk ◽  
Specific Immunoglobulin
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