scholarly journals A novel suicide shuttle plasmid for Streptococcus suis serotype 2 and Streptococcus equi ssp. zooepidemicus gene mutation

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Rui Liu ◽  
Ping Zhang ◽  
Yiqi Su ◽  
Huixing Lin ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Gene Mutation ◽  
Streptococcus Suis ◽  
Shuttle Plasmid ◽  
Streptococcus Equi ◽  
Suis Serotype ◽  
Streptococcus Suis Serotype 2

scholarly journals d-enantiomers of CATH-2 enhance the response of macrophages against Streptococcus suis serotype 2

2021 ◽  
Author(s):  
Roel M. van Harten ◽  
Johanna L.M. Tjeerdsma-van Bokhoven ◽  
Astrid de Greeff ◽  
Melanie D. Balhuizen ◽  
Albert van Dijk ◽  
...  
Keyword(s):  
Streptococcus Suis ◽  
Suis Serotype ◽  
Streptococcus Suis Serotype 2

Identification of oligopeptide-binding protein (OppA) and its role in the virulence of Streptococcus suis serotype 2

2018 ◽  
Vol 118 ◽  
pp. 322-329 ◽  
Author(s):  
Feng Zheng ◽  
Zhu-Qing Shao ◽  
Xina Hao ◽  
Qianqian Wu ◽  
Chaolong Li ◽  
...  
Keyword(s):  
Binding Protein ◽  
Streptococcus Suis ◽  
Suis Serotype ◽  
Streptococcus Suis Serotype 2

scholarly journals Characterization and Protective Activity of Monoclonal Antibodies Directed against Streptococcus suis Serotype 2 Capsular Polysaccharide Obtained Using a Glycoconjugate

Pathogens ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 139 ◽  
Author(s):  
Guillaume Goyette-Desjardins ◽  
Sonia Lacouture ◽  
Jean-Philippe Auger ◽  
René Roy ◽  
Marcelo Gottschalk ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Capsular Polysaccharide ◽  
Passive Immunization ◽  
Streptococcus Suis ◽  
Diagnostic Tools ◽  
Protective Activity ◽  
Lethal Challenge ◽  
Swine Pathogen ◽  
Suis Serotype ◽  
Streptococcus Suis Serotype 2

Streptococcus suis serotype 2 is an encapsulated bacterium and an important swine pathogen. Opsonizing antibody responses targeting capsular polysaccharides (CPSs) are protective against extracellular pathogens. To elucidate the protective activity of monoclonal antibodies (mAbs) directed against S. suis serotype 2 CPS, mice were immunized with a serotype 2 CPS-glycoconjugate and three hybridomas were isolated; of which, two were murine IgMs and the other a murine IgG1. Whereas the IgMs (mAbs 9E7 and 13C8) showed different reactivity levels with S. suis serotypes 1, 1/2, 2 and 14, the IgG1 (mAb 16H11) was shown to be serotype 2-specific. All mAbs targeted the sialylated chain of the CPSs. Using an opsonophagocytosis assay, the IgMs were opsonizing towards the S. suis serotypes to which they cross-react, while the IgG1 failed to induce bacterial elimination. In a model of mouse passive immunization followed by a lethal challenge with S. suis serotype 2, the IgG1 and IgM cross-reacting only with serotype 14 (mAb 13C8) failed to protect, while the IgM cross-reacting with serotypes 1, 1/2, and 14 (mAb 9E7) was shown to be protective by limiting bacteremia. These new mAbs show promise as new S. suis diagnostic tools, as well as potential for therapeutic applications.

Virulence genotyping and population analysis of Streptococcus suis serotype 2 isolates from China

2015 ◽  
Vol 36 ◽  
pp. 483-489 ◽  
Author(s):  
Wenyang Dong ◽  
Jiale Ma ◽  
Yinchu Zhu ◽  
Jielian Zhu ◽  
Lvfeng Yuan ◽  
...  
Keyword(s):  
Population Analysis ◽  
Streptococcus Suis ◽  
Suis Serotype ◽  
Streptococcus Suis Serotype 2
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