scholarly journals Vibrio vulnificus VvhA induces autophagy-related cell death through the lipid raft-dependent c-Src/NOX signaling pathway

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Eun Ju Song ◽  
Sei-Jung Lee ◽  
Hyeon Su Lim ◽  
Jun Sung Kim ◽  
Kyung Ku Jang ◽  
...  
Keyword(s):  
Cell Death ◽  
Signaling Pathway ◽  
Lipid Raft ◽  
Vibrio Vulnificus ◽  
Related Cell

scholarly journals Nanosphere Loaded With Curcumin Inhibits the Gastrointestinal Cell Death Signaling Pathway Induced by the Foodborne Pathogen Vibrio vulnificus

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 631 ◽  
Author(s):  
Ji-Yun Kim ◽  
Young-Min Lee ◽  
Do-Wan Kim ◽  
Taesun Min ◽  
Sei-Jung Lee
Keyword(s):  
Cell Death ◽  
Signaling Pathway ◽  
Vibrio Vulnificus ◽  
Foodborne Pathogen ◽  
Herbal Supplement ◽  
Host Cell Death ◽  
Infection Treatment ◽  
Major Factors ◽  
Related Proteins ◽  
Ht 29

Curcumin, a hydrophobic polyphenol of turmeric, has a variety of biological functions as a herbal supplement, but its poor gastric absorption rate is one of the major factors limiting its oral bioavailability. In the present study, we have investigated the functional role of a nanosphere loaded with curcumin (CN) during host cell death elicited by the Gram-negative bacterium V. vulnificus in human gastrointestinal epithelial HT-29 cells and an ileal-ligated mouse model. The recombinant protein (r) VvhA produced by V. vulnificus significantly reduced the viability of HT-29 cells. The cytotoxic effect of rVvhA was restored upon a treatment with CN (100 ng/mL), which had shown 1000-fold higher anti-apoptotic efficacy than curcumin. CN inhibited the phosphorylation of c-Src and PKC mediated by intracellular ROS responsible for the distinctive activation of the MAPKs in rVvhA-treated HT-29 cells. Interestingly, CN significantly restored the expression of Bax, Bcl-2, and cleaved caspase-3 as regulated by the phosphorylation of NF-κB. In mouse models of V. vulnificus infection, treatment with CN had a blocking effect that elevated the levels of TUNEL-positive DNA fragmentation and apoptosis-related proteins. These results indicate that CN is a functional agent that manipulates the V. vulnificus VvhA signaling pathway responsible for gastrointestinal cell death.

CUX1 controls endoplasmic reticulum stress and autophagy related cell death

2016 ◽  
Vol 54 (12) ◽  
pp. 1343-1404
Author(s):  
G Metzger ◽  
P Di Fazio ◽  
DK Bartsch ◽  
T Gress ◽  
TT Wissniowski
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endoplasmic Reticulum Stress ◽  
Related Cell

scholarly journals YAP inhibits autophagy and promotes progression of colorectal cancer via upregulating Bcl-2 expression

2021 ◽  
Vol 12 (5) ◽  
Author(s):  
Lan Jin ◽  
Yunhe Chen ◽  
Dan Cheng ◽  
Zhikai He ◽  
Xinyi Shi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Transcriptional Coactivator ◽  
Inhibitory Protein ◽  
Potential Therapeutic Target ◽  
Related Cell ◽  
Autophagy Inhibition

AbstractColorectal cancer (CRC) is one of the most aggressive and lethal cancers. The role of autophagy in the pathobiology of CRC is intricate, with opposing functions manifested in different cellular contexts. The Yes-associated protein (YAP), a transcriptional coactivator inactivated by the Hippo tumor-suppressor pathway, functions as an oncoprotein in a variety of cancers. In this study, we found that YAP could negatively regulate autophagy in CRC cells, and consequently, promote tumor progression of CRC in vitro and in vivo. Mechanistically, YAP interacts with TEAD forming a complex to upregulate the transcription of the apoptosis-inhibitory protein Bcl-2, which may subsequently facilitate cell survival by suppressing autophagy-related cell death; silencing Bcl-2 expression could alleviate YAP-induced autophagy inhibition without affecting YAP expression. Collectively, our data provide evidence for YAP/Bcl-2 as a potential therapeutic target for drug exploration against CRC.

Efferocytosis during myocardial infarction

2020 ◽  
Vol 168 (1) ◽  
pp. 1-6
Author(s):  
Chikashi Yoshimura ◽  
Akiomi Nagasaka ◽  
Hitoshi Kurose ◽  
Michio Nakaya
Keyword(s):  
Myocardial Infarction ◽  
Cell Death ◽  
Crucial Role ◽  
Molecular Mechanisms ◽  
Causes Of Death ◽  
Inflammatory Responses ◽  
Heart Cells ◽  
Dead Cell ◽  
Related Cell

Abstract Myocardial infarction is one of the major causes of death worldwide. Many heart cells die during myocardial infarction through various processes such as necrosis, apoptosis, necroptosis, autophagy-related cell death, pyroptosis and ferroptosis. These dead cells in infarcted hearts expose the so-called ‘eat-me’ signals, such as phosphatidylserine, on their surfaces, enhancing their removal by professional and non-professional phagocytes. Clearance of dead cells by phagocytes in the diseased hearts plays a crucial role in the pathology of myocardial infarction by inhibiting the inflammatory responses caused by the leakage of contents from dead cells. This review focuses on the rapidly growing understanding of the molecular mechanisms of dead cell phagocytosis, termed efferocytosis, during myocardial infarction, which contributes to the pathophysiology of myocardial infarction.

Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway

2012 ◽  
Vol 61 (2) ◽  
pp. 251-257 ◽  
Author(s):  
Haiyan Lou ◽  
Xu Jing ◽  
Dongmei Ren ◽  
Xinbing Wei ◽  
Xiumei Zhang
Keyword(s):  
Cell Death ◽  
Signaling Pathway ◽  
Pc12 Cell ◽  
Induced Neuron

Interleukin-1α-converting enzyme (ICE) and related cell death genes ICErel-II and ICErel-III map to the same PAC clone at band 11q22.2-22.3

1997 ◽  
Vol 8 (8) ◽  
pp. 611-613 ◽  
Author(s):  
Jamal Nasir ◽  
Jane L. Theilmann ◽  
John P. Vaillancourt ◽  
Neil A. Munday ◽  
Ambereen Ali ◽  
...  
Keyword(s):  
Cell Death ◽  
Converting Enzyme ◽  
Related Cell ◽  
Interleukin 1Α ◽  
Cell Death Genes ◽  
Death Genes

Edelfosine and Miltefosine Effects on Lipid Raft Properties: Membrane Biophysics in Cell Death by Antitumor Lipids

2013 ◽  
Vol 117 (26) ◽  
pp. 7929-7940 ◽  
Author(s):  
Bruno M. Castro ◽  
Aleksander Fedorov ◽  
Valentin Hornillos ◽  
Javier Delgado ◽  
A Ulises Acuña ◽  
...  
Keyword(s):  
Cell Death ◽  
Lipid Raft ◽  
Membrane Biophysics
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