scholarly journals Regulation of Airway Inflammation by G-protein Regulatory Motif Peptides of AGS3 protein

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
IL-Whan Choi ◽  
Do Whan Ahn ◽  
Jang-Kyu Choi ◽  
Hee-Jae Cha ◽  
Mee Sun Ock ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
G Protein ◽  
Regulatory Motif

scholarly journals Ionotropic and Metabotropic Proton-Sensing Receptors Involved in Airway Inflammation in Allergic Asthma

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Haruka Aoki ◽  
Chihiro Mogi ◽  
Fumikazu Okajima
Keyword(s):  
Airway Inflammation ◽  
Allergic Asthma ◽  
G Protein ◽  
Molecular Mechanisms ◽  
G Protein Coupled Receptors ◽  
Airway Smooth Muscle Cells ◽  
Transient Receptor Potential Vanilloid ◽  
Acidic Ph ◽  
Airway Responses ◽  
G Protein Coupled

An acidic microenvironment has been shown to evoke a variety of airway responses, including cough, bronchoconstriction, airway hyperresponsiveness (AHR), infiltration of inflammatory cells in the lung, and stimulation of mucus hyperproduction. Except for the participation of transient receptor potential vanilloid-1 (TRPV1) and acid-sensing ion channels (ASICs) in severe acidic pH (of less than 6.0)-induced cough and bronchoconstriction through sensory neurons, the molecular mechanisms underlying extracellular acidic pH-induced actions in the airways have not been fully understood. Recent studies have revealed that ovarian cancer G protein-coupled receptor 1 (OGR1)-family G protein-coupled receptors, which sense pH of more than 6.0, are expressed in structural cells, such as airway smooth muscle cells and epithelial cells, and in inflammatory and immune cells, such as eosinophils and dendritic cells. They function in a variety of airway responses related to the pathophysiology of inflammatory diseases, including allergic asthma. In the present review, we discuss the roles of ionotropic TRPV1 and ASICs and metabotropic OGR1-family G protein-coupled receptors in the airway inflammation and AHR in asthma and respiratory diseases.

scholarly journals G-Protein-Coupled Estrogen Receptor Agonist Suppresses Airway Inflammation in a Mouse Model of Asthma through IL-10

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0123210 ◽  
Author(s):  
Masamichi Itoga ◽  
Yasunori Konno ◽  
Yuki Moritoki ◽  
Yukiko Saito ◽  
Wataru Ito ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Mouse Model ◽  
Airway Inflammation ◽  
G Protein ◽  
Receptor Agonist ◽  
G Protein Coupled

scholarly journals Correction: G-Protein-Coupled Estrogen Receptor Agonist Suppresses Airway Inflammation in a Mouse Model of Asthma through IL-10

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0136326 ◽  
Author(s):  
Masamichi Itoga ◽  
Yasunori Konno ◽  
Yuki Moritoki ◽  
Yukiko Saito ◽  
Wataru Ito ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Mouse Model ◽  
Airway Inflammation ◽  
G Protein ◽  
Receptor Agonist ◽  
G Protein Coupled

scholarly journals Stabilization of the GDP-bound Conformation of Giα by a Peptide Derived from the G-protein Regulatory Motif of AGS3

2000 ◽  
Vol 275 (43) ◽  
pp. 33193-33196 ◽  
Author(s):  
Yuri K. Peterson ◽  
Michael L. Bernard ◽  
Hongzheng Ma ◽  
Starr Hazard ◽  
Stephen G. Graber ◽  
...  
Keyword(s):  
G Protein ◽  
Regulatory Motif

scholarly journals Cutting Edge: A Critical Role for the G Protein-Coupled Receptor mFPR2 in Airway Inflammation and Immune Responses

2010 ◽  
Vol 184 (7) ◽  
pp. 3331-3335 ◽  
Author(s):  
Keqiang Chen ◽  
Yingying Le ◽  
Ying Liu ◽  
Wanghua Gong ◽  
Guoguang Ying ◽  
...  
Keyword(s):  
Immune Responses ◽  
Airway Inflammation ◽  
G Protein ◽  
Critical Role ◽  
Cutting Edge ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

G Protein βγ Subunit-dependent Signaling Mediates AirwayHhyperreactivity And Allergic Airway Inflammation

2010 ◽  
Author(s):  
Gustavo Nino ◽  
Aihua Hu ◽  
Judith Grunstein ◽  
Joesph M. McDonough ◽  
Portia Kreiger ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
G Protein ◽  
Allergic Airway Inflammation

scholarly journals Direct Coupling of a Seven-Transmembrane-Span Receptor to a Gαi G-Protein Regulatory Motif Complex

2015 ◽  
Vol 88 (2) ◽  
pp. 231-237 ◽  
Author(s):  
William G. Robichaux ◽  
Sukru S. Oner ◽  
Stephen M. Lanier ◽  
Joe B. Blumer
Keyword(s):  
G Protein ◽  
Direct Coupling ◽  
Regulatory Motif ◽  
Transmembrane Span
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