scholarly journals Genetic polymorphisms of cell adhesion molecules in Behcet’s disease in a Chinese Han population

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Minming Zheng ◽  
Lijun Zhang ◽  
Hongsong Yu ◽  
Jiayue Hu ◽  
Qingfeng Cao ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Genetic Polymorphisms ◽  
Cell Adhesion Molecules ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Behcet's Disease ◽  
Han Population

STAT4 polymorphism in a Chinese Han population with Vogt–Koyanagi–Harada syndrome and Behçet's disease

2010 ◽  
Vol 71 (7) ◽  
pp. 723-726 ◽  
Author(s):  
Ke Hu ◽  
Peizeng Yang ◽  
Zhengxuan Jiang ◽  
Shengping Hou ◽  
Liping Du ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Behcet's Disease ◽  
Han Population

IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population

2010 ◽  
Vol 69 (7) ◽  
pp. 1325-1328 ◽  
Author(s):  
Z. Jiang ◽  
P. Yang ◽  
S. Hou ◽  
L. Du ◽  
L. Xie ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Behcet's Disease ◽  
Han Population

scholarly journals Evidence for Association of Cell Adhesion Molecules Pathway and NLGN1 Polymorphisms with Schizophrenia in Chinese Han Population

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0144719 ◽  
Author(s):  
Zhengrong Zhang ◽  
Hao Yu ◽  
Sisi Jiang ◽  
Jinmin Liao ◽  
Tianlan Lu ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals A single nucleotide polymorphism in the IL1RL1 gene is associated with Behcet’s disease in a Chinese Han population

2021 ◽  
Vol 14 (9) ◽  
pp. 1315-1320
Author(s):  
Xin-Shu Liu ◽  
◽  
Si Chen ◽  
Chan Zhao ◽  
Fei Gao ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Chinese Han Population ◽  
Variant Allele ◽  
Gene Region ◽  
Chinese Han ◽  
Single Nucleotide ◽  
Behcet's Disease ◽  
Han Population

AIM: To explore the association of single nucleotide polymorphisms (SNPs) in the IL33/IL1RL1 gene region with the susceptibility to Behcet’s disease (BD) in a Chinese Han population. METHODS: A total of eight SNPs in the candidate gene region (rs11792633, rs7025417, rs10975519 and rs1048274 in IL33; rs2310220, rs12712142, rs13424006 and rs3821204 in IL1RL1) were genotyped in783 BD patients and 701 healthy controls by the Sequenom Mass Array iPLEX platform. RESULTS: A statistically significant association was observed between IL1RL1 rs12712142 and BD patients. The frequency of IL1RL1 rs12712142 variant allele A was significantly lower in BD patients than that in controls (OR=0.8, 95%CI: 0.69-0.94, Pc=0.039); the genotype distribution (Pc=0.043) and additive and dominant genetic model analyses (OR=0.8, 95%CI: 0.69-0.94, Pc=0.040 and OR=0.72, 95%CI: 0.58-0.88, Pc=0.011) also indicated a strong association between rs12712142 and BD patients. CONCLUSION: This is the first study to reveal the association between IL1RL1 rs12712142 variant allele A and the decreased risk of BD in the Chinese Han population, indicating a protective role of IL1RL1 in the pathogenesis of BD.

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