scholarly journals Naringin ameliorates bone loss induced by sciatic neurectomy and increases Semaphorin 3A expression in denervated bone

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Xinlong Ma ◽  
Jianwei Lv ◽  
Xiaolei Sun ◽  
Jianxiong Ma ◽  
Guosheng Xing ◽  
...  
Keyword(s):  
Bone Loss ◽  
Semaphorin 3A ◽  
Sciatic Neurectomy

scholarly journals Klotho-deficient mice are resistant to bone loss induced by unloading due to sciatic neurectomy

2001 ◽  
Vol 168 (2) ◽  
pp. 347-351 ◽  
Author(s):  
T Yamashita ◽  
I Sekiya ◽  
N Kawaguchi ◽  
K Kashimada ◽  
A Nifuji ◽  
...  
Keyword(s):  
Bone Loss ◽  
Cortical Bone ◽  
Gene Product ◽  
Mutant Mice ◽  
Wild Type ◽  
Micro Computed Tomography ◽  
Klotho Gene ◽  
Sciatic Neurectomy ◽  
And Control ◽  
Deficient Mice

Unloading induces bone loss as seen in experimental animals as well as in space flight or in bed-ridden conditions; however, the mechanisms involved in this phenomenon are not fully understood. Klotho mutant mice exhibit osteopetrosis in the metaphyseal regions indicating that the klotho gene product is involved in the regulation of bone metabolism. To examine whether the klotho gene product is involved in the unloading-induced bone loss, the response of the osteopetrotic cancellous bones in these mice was investigated. Sciatic nerve resection was conducted using klotho mutant (kl/kl) and control heterozygous mice (+/kl) and its effect on bone was examined by micro-computed tomography (microCT). As reported previously for wild-type mice (+/+), about 30% bone loss was induced in heterozygous mice (+/kl) by unloading due to neurectomy within 30 days of the surgery. By contrast, kl/kl mice were resistant against bone loss induced by unloading after neurectomy. Unloading due to neurectomy also induced a small but significant bone loss in the cortical bone of the mid-shaft of the femur in the heterozygous mice; no reduction in the cortical bone was observed in kl/kl mice. These results indicate that klotho mutant mice are resistant against bone loss induced by unloading due to neurectomy in both cortical and trabecular bone and indicate that klotho is one of the molecules involved in the loss of bone by unloading.

The effects of systemic chemical sympathectomy on local bone loss induced by sciatic neurectomy

2011 ◽  
Vol 16 (5) ◽  
pp. 629-637 ◽  
Author(s):  
Tsang-Hai Huang ◽  
Hsin-Shih Lin ◽  
Hsiun-Ing Chen ◽  
Rong-Sen Yang
Keyword(s):  
Bone Loss ◽  
Chemical Sympathectomy ◽  
Local Bone ◽  
Sciatic Neurectomy

Menatetrenone rescues bone loss by improving osteoblast dysfunction in rats immobilized by sciatic neurectomy

Life Sciences ◽  
2005 ◽  
Vol 76 (15) ◽  
pp. 1721-1734 ◽  
Author(s):  
Yoshiko Iwasaki-Ishizuka ◽  
Hideyuki Yamato ◽  
Hisashi Murayama ◽  
Ikuko Ezawa ◽  
Kiyoshi Kurokawa ◽  
...  
Keyword(s):  
Bone Loss ◽  
Sciatic Neurectomy

scholarly journals Sciatic neurectomy-related cortical bone loss exhibits delayed onset yet stabilises more rapidly than trabecular bone

Bone Reports ◽  
2021 ◽  
pp. 101116
Author(s):  
Samuel Monzem ◽  
Behzad Javaheri ◽  
Roberto Lopes de Souza ◽  
Andrew Anthony Pitsillides
Keyword(s):  
Bone Loss ◽  
Trabecular Bone ◽  
Cortical Bone ◽  
Cortical Bone Loss ◽  
Delayed Onset ◽  
Sciatic Neurectomy

Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss

2016 ◽  
Vol 30 ◽  
pp. 311-318 ◽  
Author(s):  
S. Saad ◽  
A.A.S.S.K. Dharmapatni ◽  
T.N. Crotti ◽  
M.D. Cantley ◽  
K. Algate ◽  
...  
Keyword(s):  
Bone Loss ◽  
Semaphorin 3A ◽  
Neuropilin 1

scholarly journals Dramatic Decrease of Innervation Density in Bone after Ovariectomy

Endocrinology ◽  
2005 ◽  
Vol 146 (1) ◽  
pp. 503-510 ◽  
Author(s):  
B. Burt-Pichat ◽  
M. H. Lafage-Proust ◽  
F. Duboeuf ◽  
N. Laroche ◽  
C. Itzstein ◽  
...  
Keyword(s):  
Image Analysis ◽  
Bone Loss ◽  
Density Measurement ◽  
Nerve Fibers ◽  
Quantitative Image Analysis ◽  
Mineral Density ◽  
Functional Link ◽  
Sciatic Neurectomy ◽  
Quantitative Image ◽  
Neurofilament 200

Recent studies have demonstrated that bone is highly innervated and contains neuromediators that have functional receptors on bone cells. However, no data exist concerning the quantitative changes of innervation during bone loss associated with estrogen withdrawal. To study the involvement of nerve fibers in the regulation of bone remodeling, we have evaluated the modifications of innervation in a classical in vivo model of osteopenia in rats, ovariectomy (OVX). Skeletal innervation was studied by immunocytochemistry using antibodies directed against specific neuronal markers, neurofilament 200 and synaptophysin, and the neuromediator glutamate. Sciatic neurectomy, another model of bone loss due to limb denervation and paralysis, was used to validate our quantitative image analysis technique of immunostaining for nerve markers. Female Wistar rats at 12 wk of age were sham-operated (SHAM) or ovariectomized (OVX). Bone mineral density measurement and bone histomorphometry analysis of tibiae 14 d after surgery demonstrated a significant bone loss in OVX compared with SHAM. We observed an important reduction of nerve profile density in tibiae of OVX animals compared with SHAM animals, whereas innervation density in skin and muscles was similar for OVX and control rats. Quantitative image analysis of immunostainings demonstrated a significant decrease of the percentage of immunolabeling per total bone volume of neurofilament 200, synaptophysin, and glutamate in both the primary and secondary spongiosa of OVX rats compared with SHAM. These data indicate for the first time that OVX-induced bone loss in rat tibiae is associated with a reduction in nerve profile density, suggesting a functional link between the nervous system and the bone loss after ovariectomy.

Bone loss in patients with Crohn's disease: A longterm-follow up study

2001 ◽  
Vol 120 (5) ◽  
pp. A628-A628
Author(s):  
P CLEMENS ◽  
V HAWIG ◽  
M MUELLER ◽  
J SCAENZLIN ◽  
B KLUMP ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bone Loss ◽  
Follow Up Study
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