scholarly journals Avian influenza viruses that cause highly virulent infections in humans exhibit distinct replicative properties in contrast to human H1N1 viruses

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Philippe F. Simon ◽  
Marc-Antoine de La Vega ◽  
Éric Paradis ◽  
Emelissa Mendoza ◽  
Kevin M. Coombs ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza Viruses ◽  
Avian Influenza Viruses ◽  
Highly Virulent

One-step fast and label-free imaging array for multiplexed detection of trace avian influenza viruses

2021 ◽  
pp. 338645
Author(s):  
Dagang Jiang ◽  
Yafei Tian ◽  
Yujiao Zhang ◽  
Xueyun Lu ◽  
Dan Xiao ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza Viruses ◽  
Label Free ◽  
Avian Influenza Viruses ◽  
Multiplexed Detection ◽  
Imaging Array ◽  
One Step

scholarly journals Pathogenic Assessment of Avian Influenza Viruses in Migratory Birds

2021 ◽  
pp. 1-40
Author(s):  
Eun-Ha Kim ◽  
Young-ll Kim ◽  
Se Mi Kim ◽  
Kwang-Min Yu ◽  
Mark Anthony B. Casel ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Migratory Birds ◽  
Influenza Viruses ◽  
Avian Influenza Viruses

scholarly journals Development of an immunochromatographic strip for rapid detection of H7 subtype avian influenza viruses

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Ge Li ◽  
Xun Wang ◽  
Qingmei Li ◽  
Jifei Yang ◽  
Xiao Liu ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Point Of Care ◽  
Influenza Viruses ◽  
Control Line ◽  
Avian Influenza Viruses ◽  
Igg Antibody ◽  
Immunochromatographic Strip ◽  
Live Poultry ◽  
Pathogenic Viruses ◽  
H7 Subtype

Abstract Background H7N9 avian influenza virus (AIV) including highly and low pathogenic viruses have been detected in China since 2013. H7N9 AIV has a high mortality rate after infection in humans, and most human cases have close contacted with poultry in the live poultry market. Therefore, it is necessary to develop a rapid point-of-care testing (POCT) technique for H7N9 AIV detection. Methods The H7N9 AIV was inactivated and purified, and was used as the antigen to immunize BALB/c. Twelve H7-HA specific monoclonal antibodies (McAbs) were produced through the hybridoma technique. The McAb 10A8 was conjugated with colloid gold as detecting antibody; McAb 9B6 was dispensed on the nitrocellulose membran as the capture test line and the Goat-anti mouse IgG antibody was dispensed as control line respectively. The immunochromatographic strip was prepared. Results The analysis of ELISA and virus neutralization test showed that the obtained McAbs specifically recognized H7 HA. Based on the prepared strip, the detection of H7 AIV was achieved within 10 min. No cross-reaction occurred between H7 AIVs and other tested viruses. The detection limit of the strip for H7 was 2.4 log10EID50/0.1 mL for chicken swab samples. Conclusion The McAbs were specific for H7 and the immunochromatographic strip developed in this study was convenient, rapid and reliable for the detection of H7 AIV. The strip could provide an effective method for the rapid and early detection of H7 AIV.

scholarly journals Heterologous Humoral Response against H5N1, H7N3, and H9N2 Avian Influenza Viruses after Seasonal Vaccination in a European Elderly Population

Vaccines ◽  
2017 ◽  
Vol 5 (3) ◽  
pp. 17 ◽  
Author(s):  
Ivan Sanz ◽  
Silvia Rojo ◽  
Sonia Tamames ◽  
José Eiros ◽  
Raúl Ortiz de Lejarazu
Keyword(s):  
Avian Influenza ◽  
Elderly Population ◽  
Humoral Response ◽  
Influenza Viruses ◽  
Avian Influenza Viruses

scholarly journals Antibody responses to avian influenza viruses in wild birds broaden with age

2016 ◽  
Vol 283 (1845) ◽  
pp. 20162159 ◽  
Author(s):  
Sarah C. Hill ◽  
Ruth J. Manvell ◽  
Bodo Schulenburg ◽  
Wendy Shell ◽  
Paul S. Wikramaratna ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Haemagglutination Inhibition ◽  
Wild Birds ◽  
Influenza Viruses ◽  
Antibody Responses ◽  
Immune Recognition ◽  
Avian Influenza Viruses ◽  
Highly Pathogenic ◽  
Age Related ◽  
Pathogenic H5n1

For viruses such as avian influenza, immunity within a host population can drive the emergence of new strains by selecting for viruses with novel antigens that avoid immune recognition. The accumulation of acquired immunity with age is hypothesized to affect how influenza viruses emerge and spread in species of different lifespans. Despite its importance for understanding the behaviour of avian influenza viruses, little is known about age-related accumulation of immunity in the virus's primary reservoir, wild birds. To address this, we studied the age structure of immune responses to avian influenza virus in a wild swan population ( Cygnus olor ), before and after the population experienced an outbreak of highly pathogenic H5N1 avian influenza in 2008. We performed haemagglutination inhibition assays on sampled sera for five avian influenza strains and show that breadth of response accumulates with age. The observed age-related distribution of antibody responses to avian influenza strains may explain the age-dependent mortality observed during the highly pathogenic H5N1 outbreak. Age structures and species lifespan are probably important determinants of viral epidemiology and virulence in birds.

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