scholarly journals Adenosine receptor agonist NECA increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier modulation

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Chih-Chung Cheng ◽  
Ya Lan Yang ◽  
Kate Hsiurong Liao ◽  
Ted Weita Lai
Keyword(s):  
Molecular Weight ◽  
Blood Brain Barrier ◽  
Adenosine Receptor ◽  
Receptor Agonist ◽  
Brain Barrier ◽  
Low Molecular Weight ◽  
Blood Brain ◽  
Adenosine Receptor Agonist

scholarly journals Voltage-sensitive dye delivery through the blood brain barrier using adenosine receptor agonist regadenoson

2018 ◽  
Vol 9 (8) ◽  
pp. 3915 ◽  
Author(s):  
Rebecca W. Pak ◽  
Jeeun Kang ◽  
Heather Valentine ◽  
Leslie M. Loew ◽  
Daniel L. J. Thorek ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Adenosine Receptor ◽  
Receptor Agonist ◽  
Brain Barrier ◽  
Voltage Sensitive Dye ◽  
Blood Brain ◽  
Adenosine Receptor Agonist

scholarly journals Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5166
Author(s):  
Yeju Liu ◽  
Yuyang You ◽  
Juan Lu ◽  
Xi Chen ◽  
Zhihong Yang
Keyword(s):  
Molecular Weight ◽  
Blood Brain Barrier ◽  
The Body ◽  
Brain Barrier ◽  
Low Molecular Weight ◽  
Pharmacological Activities ◽  
Therapeutic Applications ◽  
Blood Brain ◽  
Pass Through ◽  
Anti Inflammation

Pterostilbene is a natural 3,5-dimethoxy analog of resveratrol. This stilbene compound has a strong bioactivity and exists widely in Dalbergia and Vaccinium spp. Besides natural extraction, pterostilbene can be obtained by biosynthesis. Pterostilbene has become popular because of its remarkable pharmacological activities, such as anti-tumor, anti-oxidation, anti-inflammation, and neuroprotection. Pterostilbene can be rapidly absorbed and is widely distributed in tissues, but it does not seriously accumulate in the body. Pterostilbene can easily pass through the blood-brain barrier because of its low molecular weight and good liposolubility. In this review, the studies performed in the last three years on resources, synthesis, bioactivity, and pharmacokinetics of pterostilbene are summarized. This review focuses on the effects of pterostilbene on certain diseases to explore its targets, explain the possible mechanism, and look for potential therapeutic applications.

Monitoring Blood-Brain Barrier Status in a Rat Model of Glioma Receiving Therapy: Dual Injection of Low-Molecular-Weight and Macromolecular MR Contrast Media

Radiology ◽  
2010 ◽  
Vol 257 (2) ◽  
pp. 342-352 ◽  
Author(s):  
Benjamin Lemasson ◽  
Raphaël Serduc ◽  
Cécile Maisin ◽  
Audrey Bouchet ◽  
Nicolas Coquery ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Contrast Media ◽  
Blood Brain Barrier ◽  
Rat Model ◽  
Brain Barrier ◽  
Low Molecular Weight ◽  
Blood Brain ◽  
Dual Injection ◽  
Mr Contrast Media

Accessing the Blood-Brain Barrier to Treat Brain Disorders

2019 ◽  
Vol 9 (3) ◽  
pp. 198-209
Author(s):  
M. Sureshkumar ◽  
A. Pandian
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Low Molecular Weight ◽  
Brain Disorders ◽  
Permeable Membrane ◽  
Drug Molecules ◽  
Blood Brain ◽  
Therapeutic Molecules ◽  
Pass Through ◽  
The Brain

: Crossing the blood-brain barrier (BBB) and treating brain disorders by delivering therapeutic agents to specific regions of the brain is a challenge. The BBB, naturally evolved, protective physiological barrier acts as a selective permeable membrane in such a way that it allows only nonionic molecules and molecules of low molecular weight to pass through. Treating brain tumor has become a great challenge as the drug molecules of larger size are not able to cross the BBB and reach the target site. The incompetence of techniques for brain-specific delivery of therapeutic molecules has led researchers to increasingly explore the diagnosis and treatment of disorders incurable with present techniques. This article is to discuss the various techniques or methods to deliver drugs to the brain crossing the BBB.

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