scholarly journals Redox proteins of hydroxylating bacterial dioxygenases establish a regulatory cascade that prevents gratuitous induction of tetralin biodegradation genes

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Laura Ledesma-García ◽  
Ana Sánchez-Azqueta ◽  
Milagros Medina ◽  
Francisca Reyes-Ramírez ◽  
Eduardo Santero
Keyword(s):  
Redox Proteins ◽  
Regulatory Cascade ◽  
Biodegradation Genes

Involvement of a novel regulatory cascade consisting of SET-H3K18ac/H3K27ac-53BP1 in Cr(VI)-induced malignant transformation of 16HBE cells

2021 ◽  
Vol 339 ◽  
pp. 70-77
Author(s):  
Zhihong Chen ◽  
Jiacheng Zhong ◽  
Xiaohu Ren ◽  
Wei Liu ◽  
Desheng Wu ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Regulatory Cascade

Electron transfer between redox enzymes and electrodes through the artificial redox proteins and its application for biosensors

2000 ◽  
Vol 65 (1-3) ◽  
pp. 144-146 ◽  
Author(s):  
Hiroaki Shinohara ◽  
Taichi Kusaka ◽  
Eisaku Yokota ◽  
Reiko Monden ◽  
Masahiko Sisido
Keyword(s):  
Electron Transfer ◽  
Redox Enzymes ◽  
Redox Proteins

scholarly journals FarRRegulates the farAB-Encoded Efflux Pump of Neisseriagonorrhoeae via an MtrR RegulatoryMechanism

2003 ◽  
Vol 185 (24) ◽  
pp. 7145-7152 ◽  
Author(s):  
E.-H. Lee ◽  
C. Rouquette-Loughlin ◽  
J. P. Folster ◽  
W. M. Shafer
Keyword(s):  
Regulatory Mechanism ◽  
Efflux Pump ◽  
Regulatory Protein ◽  
Transcriptional Repressors ◽  
Sequence Database ◽  
Mobility Shift ◽  
Pump System ◽  
Regulatory Cascade ◽  
Genome Sequence Database ◽  
Gel Mobility Shift

ABSTRACT The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. It was previously observed that expression of the farAB operon was positively regulated by MtrR, which is a repressor of the mtrCDE-encoded efflux pump system (E.-H. Lee and W. M. Shafer, Mol. Microbiol. 33:839-845, 1999). This regulation was believed to be indirect since MtrR did not bind to the farAB promoter. In this study, computer analysis of the gonococcal genome sequence database, lacZ reporter fusions, and gel mobility shift assays were used to elucidate the regulatory mechanism by which expression of the farAB operon is modulated by MtrR in gonococci. We identified a regulatory protein belonging to the MarR family of transcriptional repressors and found that it negatively controls expression of farAB by directly binding to the farAB promoter. We designated this regulator FarR to signify its role in regulating the farAB operon. We found that MtrR binds to the farR promoter, thereby repressing farR expression. Hence, MtrR regulates farAB in a positive fashion by modulating farR expression. This MtrR regulatory cascade seems to play an important role in adjusting levels of the FarAB and MtrCDE efflux pumps to prevent their excess expression in gonococci.

scholarly journals Analysis of a Gene Regulatory Cascade Mediating Circadian Rhythm in Zebrafish

2013 ◽  
Vol 9 (2) ◽  
pp. e1002940 ◽  
Author(s):  
Ying Li ◽  
Guang Li ◽  
Haifang Wang ◽  
Jiulin Du ◽  
Jun Yan
Keyword(s):  
Circadian Rhythm ◽  
Regulatory Cascade ◽  
Gene Regulatory

Differential regulation of redox proteins and chaperones in HbEβ-thalassemia erythrocyte proteome

2009 ◽  
Vol 4 (5) ◽  
pp. 480-488 ◽  
Author(s):  
Dipankar Bhattacharya ◽  
Sutapa Saha ◽  
Sumanta Basu ◽  
Sudipa Chakravarty ◽  
Amit Chakravarty ◽  
...  
Keyword(s):  
Differential Regulation ◽  
Redox Proteins
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