scholarly journals In vivo imaging of prostate cancer using an anti-PSMA scFv fragment as a probe

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Claire Mazzocco ◽  
Giulio Fracasso ◽  
Coralie Germain-Genevois ◽  
Nathalie Dugot-Senant ◽  
Mariangela Figini ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
In Vivo Imaging ◽  
Scfv Fragment

In vivo imaging reveals prostate pathology in the PTEN knockout murine model of prostate cancer

2016 ◽  
Author(s):  
Alysha Bhatti ◽  
Almeida Gilberto Serrano de ◽  
Serena Tommasini Ghelfi ◽  
Alwyn Dart ◽  
Anabel Varela-Carver ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Murine Model ◽  
In Vivo Imaging

scholarly journals MP37-10 11B6 MAB: APPLICATIONS FOR PROSTATE CANCER STAGING, INTRA-OPERATIVE GUIDANCE AND EVALUATION OF TREATMENT BY IN VIVO IMAGING OF HK2

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Daniel Thorek ◽  
Katharina Braun ◽  
Jason Lewis ◽  
Peter Scardino ◽  
Hans Lilja ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
In Vivo Imaging ◽  
Cancer Staging ◽  
Prostate Cancer Staging

scholarly journals In Vivo Imaging of Prostate Cancer Using [68Ga]-Labeled Bombesin Analog BAY86-7548

2013 ◽  
Vol 19 (19) ◽  
pp. 5434-5443 ◽  
Author(s):  
Esa Kähkönen ◽  
Ivan Jambor ◽  
Jukka Kemppainen ◽  
Kaisa Lehtiö ◽  
Tove J. Grönroos ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
In Vivo Imaging

545 PEPTIDE RECEPTOR TARGETING IS SUPERIOR TO METABOLIC TARGETING FOR IN VIVO IMAGING OF HUMAN PROSTATE CANCER XENOGRAFTS

2010 ◽  
Vol 183 (4S) ◽  
Author(s):  
Rogier P.J. Schroeder ◽  
Saskia C. Berndsen ◽  
Corine de Ligt ◽  
Susanne Reneman ◽  
Eric P. Krenning ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
In Vivo Imaging ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Receptor Targeting ◽  
Peptide Receptor ◽  
Metabolic Targeting

scholarly journals Contrast-Enhanced In Vivo Imaging of Breast and Prostate Cancer Cells by MRI

Cell Cycle ◽  
2005 ◽  
Vol 5 (1) ◽  
pp. 113-119 ◽  
Author(s):  
Olga Rodriguez ◽  
Stanley Fricke ◽  
Christopher Chien ◽  
Luis Dettin ◽  
John VanMeter ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
In Vivo Imaging ◽  
Prostate Cancer Cells ◽  
Contrast Enhanced ◽  
Breast And Prostate Cancer

scholarly journals M13-templated magnetic nanoparticles for targeted in vivo imaging of prostate cancer

2012 ◽  
Vol 7 (10) ◽  
pp. 677-682 ◽  
Author(s):  
Debadyuti Ghosh ◽  
Youjin Lee ◽  
Stephanie Thomas ◽  
Aditya G. Kohli ◽  
Dong Soo Yun ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Magnetic Nanoparticles ◽  
In Vivo Imaging

In vivo imaging of prostate cancer involving bone in a mouse model

The Prostate ◽  
2006 ◽  
Vol 67 (1) ◽  
pp. 50-60 ◽  
Author(s):  
Vikas Kundra ◽  
Chaan S. Ng ◽  
Jingfei Ma ◽  
James A. Bankson ◽  
Roger E. Price ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mouse Model ◽  
In Vivo Imaging

scholarly journals High-affinity Near-infrared Fluorescent Small-molecule Contrast Agents for In Vivo Imaging of Prostate-specific Membrane Antigen

2005 ◽  
Vol 4 (4) ◽  
pp. 7290.2005.05163 ◽  
Author(s):  
Valerie Humblet ◽  
Rena Lapidus ◽  
Larry R. Williams ◽  
Takashi Tsukamoto ◽  
Camilo Rojas ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Small Molecule ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Expression System ◽  
High Yield ◽  
Definitive Treatment ◽  
Fluorescent Light ◽  
High Affinity

Surgical resection remains a definitive treatment for prostate cancer. Yet, prostate cancer surgery is performed without image guidance for tumor margin, extension beyond the capsule and lymph node positivity, and without verification of other occult metastases in the surgical field. Recently, several imaging systems have been described that exploit near-infrared (NIR) fluorescent light for sensitive, real-time detection of disease pathology intraoperatively. In this study, we describe a high-affinity (9 nM), single nucleophile-containing, small molecule specific for the active site of the enzyme PSMA. We demonstrate production of a tetra-sulfonated heptamethine indocyanine NIR fluorescent derivative of this molecule using a high-yield LC/MS purification strategy. Interestingly, NIR fluorophore conjugation improves affinity over 20-fold, and we provide mechanistic insight into this observation. We describe the preparative production of enzymatically active PSMA using a baculovirus expression system and an adenovirus that co-expresses PSMA and GFP. We demonstrate sensitive and specific in vitro imaging of endogenous and ectopically expressed PSMA in human cells and in vivo imaging of xenograft tumors. We also discuss chemical strategies for improving performance even further. Taken together, this study describes nearly complete preclinical development of an optically based small-molecule contrast agent for image-guided surgery.

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