scholarly journals Low-intensity pulsed ultrasound treatment improved the rate of autograft peripheral nerve regeneration in rat

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Wenli Jiang ◽  
Yuexiang Wang ◽  
Jie Tang ◽  
Jiang Peng ◽  
Yu Wang ◽  
...  
2016 ◽  
Vol 61 (26) ◽  
pp. 2891-2900
Author(s):  
LiRong LI ◽  
ShuXin SUN ◽  
DeAn TA ◽  
YiXian QIN ◽  
WeiQi WANG

2016 ◽  
Vol 25 (2) ◽  
pp. 137-148 ◽  
Author(s):  
Daisuke Yamaguchi ◽  
Kazuo Takeuchi ◽  
Hiroki Furuta ◽  
Shin Miyamae ◽  
Hiroshi Murakami ◽  
...  

2022 ◽  
Vol 15 ◽  
Author(s):  
Jenica Acheta ◽  
Shannon B. Z. Stephens ◽  
Sophie Belin ◽  
Yannick Poitelon

Peripheral nerve injuries are common conditions that can arise from trauma (e.g., compression, severance) and can lead to neuropathic pain as well as motor and sensory deficits. Although much knowledge exists on the mechanisms of injury and nerve regeneration, treatments that ensure functional recovery following peripheral nerve injury are limited. Schwann cells, the supporting glial cells in peripheral nerves, orchestrate the response to nerve injury, by converting to a “repair” phenotype. However, nerve regeneration is often suboptimal in humans as the repair Schwann cells do not sustain their repair phenotype long enough to support the prolonged regeneration times required for successful nerve regrowth. Thus, numerous strategies are currently focused on promoting and extending the Schwann cells repair phenotype. Low-intensity ultrasound (LIU) is a non-destructive therapeutic approach which has been shown to facilitate peripheral nerve regeneration following nerve injury in rodents. Still, clinical trials in humans are scarce and limited to small population sizes. The benefit of LIU on nerve regeneration could possibly be mediated through the repair Schwann cells. In this review, we discuss the known and possible molecular mechanisms activated in response to LIU in repair Schwann cells to draw support and attention to LIU as a compelling regenerative treatment for peripheral nerve injury.


2016 ◽  
Vol 124 (3) ◽  
pp. 246-250 ◽  
Author(s):  
Mai Sato ◽  
Mitsuru Motoyoshi ◽  
Masamichi Shinoda ◽  
Koichi Iwata ◽  
Noriyoshi Shimizu

Sign in / Sign up

Export Citation Format

Share Document