scholarly journals Carnosic acid slows photoreceptor degeneration in the Pde6brd10 mouse model of retinitis pigmentosa

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Kai Kang ◽  
Matthew J. Tarchick ◽  
Xiaoshan Yu ◽  
Craig Beight ◽  
Ping Bu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Retinitis Pigmentosa ◽  
Carnosic Acid ◽  
Photoreceptor Degeneration

scholarly journals Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa

2018 ◽  
Vol 8 ◽  
Author(s):  
Thomas Blank ◽  
Tobias Goldmann ◽  
Mirja Koch ◽  
Lukas Amann ◽  
Christian Schön ◽  
...  
Keyword(s):  
Mouse Model ◽  
Retinitis Pigmentosa ◽  
Microglia Activation ◽  
Photoreceptor Degeneration

scholarly journals Luteolin delays photoreceptor degeneration in a mouse model of retinitis pigmentosa

2021 ◽  
Vol 16 (10) ◽  
pp. 2109
Author(s):  
Ang Li ◽  
Ying Xu ◽  
Xiao-Bin Liu ◽  
Feng Liu ◽  
Yi-Yao Liang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Retinitis Pigmentosa ◽  
Photoreceptor Degeneration

Melatonin delays photoreceptor degeneration in a mouse model of autosomal recessive retinitis pigmentosa

2017 ◽  
Vol 63 (3) ◽  
pp. e12428 ◽  
Author(s):  
Xiao-Jian Xu ◽  
Shu-Min Wang ◽  
Ying Jin ◽  
Yun-Tao Hu ◽  
Kang Feng ◽  
...  
Keyword(s):  
Mouse Model ◽  
Retinitis Pigmentosa ◽  
Autosomal Recessive ◽  
Photoreceptor Degeneration

scholarly journals Lutein delays photoreceptor degeneration in a mouse model of retinitis pigmentosa

2022 ◽  
Vol 17 (7) ◽  
pp. 1596
Author(s):  
Ying Xu ◽  
Xue-Song Mi ◽  
Shi-Bo Tang ◽  
Hui-Jun Zhang ◽  
Xiao-Bin Liu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Retinitis Pigmentosa ◽  
Photoreceptor Degeneration

scholarly journals Temporal Contrast Sensitivity Increases Despite Photoreceptor Degeneration in a Mouse Model of Retinitis Pigmentosa

eNeuro ◽  
2021 ◽  
pp. ENEURO.0020-21.2021
Author(s):  
Rose L. Pasquale ◽  
Ying Guo ◽  
Yumiko Umino ◽  
Barry Knox ◽  
Eduardo Solessio
Keyword(s):  
Mouse Model ◽  
Retinitis Pigmentosa ◽  
Contrast Sensitivity ◽  
Photoreceptor Degeneration ◽  
Temporal Contrast

scholarly journals Photoreceptor degeneration changes magnetic resonance imaging features in a mouse model of retinitis pigmentosa

2011 ◽  
Vol 65 (6) ◽  
pp. 1793-1798 ◽  
Author(s):  
Qing Wang ◽  
Sheng-Kwei Song ◽  
Huiying Zhang ◽  
Bruce A. Berkowitz ◽  
Shiming Chen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Mouse Model ◽  
Retinitis Pigmentosa ◽  
Imaging Features ◽  
Photoreceptor Degeneration ◽  
Resonance Imaging

scholarly journals Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1‐CX3CR1 signaling in a mouse model of retinitis pigmentosa

Glia ◽  
2016 ◽  
Vol 64 (9) ◽  
pp. 1479-1491 ◽  
Author(s):  
Matthew K. Zabel ◽  
Lian Zhao ◽  
Yikui Zhang ◽  
Shaimar R. Gonzalez ◽  
Wenxin Ma ◽  
...  
Keyword(s):  
Mouse Model ◽  
Retinitis Pigmentosa ◽  
Photoreceptor Degeneration ◽  
Microglial Phagocytosis

scholarly journals The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia

2020 ◽  
Vol 22 (1) ◽  
pp. 52
Author(s):  
Mirja Koch ◽  
Constanze Scheel ◽  
Hongwei Ma ◽  
Fan Yang ◽  
Michael Stadlmeier ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Mouse Model ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Cone Photoreceptor ◽  
Photoreceptor Degeneration ◽  
Dependent Protein Kinase ◽  
Genetic Ablation ◽  
Cgmp Dependent Protein Kinase ◽  
Dependent Protein

Mutations in the CNGA3 gene, which encodes the A subunit of the cyclic guanosine monophosphate (cGMP)-gated cation channel in cone photoreceptor outer segments, cause total colour blindness, also referred to as achromatopsia. Cones lacking this channel protein are non-functional, accumulate high levels of the second messenger cGMP and degenerate over time after induction of ER stress. The cell death mechanisms that lead to loss of affected cones are only partially understood. Here, we explored the disease mechanisms in the Cnga3 knockout (KO) mouse model of achromatopsia. We found that another important effector of cGMP, the cGMP-dependent protein kinase 2 (Prkg2) is crucially involved in cGMP cytotoxicity of cones in Cnga3 KO mice. Virus-mediated knockdown or genetic ablation of Prkg2 in Cnga3 KO mice counteracted degeneration and preserved the number of cones. Analysis of markers of endoplasmic reticulum stress and unfolded protein response confirmed that induction of these processes in Cnga3 KO cones also depends on Prkg2. In conclusion, we identified Prkg2 as a novel key mediator of cone photoreceptor degeneration in achromatopsia. Our data suggest that this cGMP mediator could be a novel pharmacological target for future neuroprotective therapies.

In vivo potency testing of subretinal rAAV5.hCNGB1 gene therapy in the Cngb1 knockout mouse model of retinitis pigmentosa

2021 ◽  
Author(s):  
Johanna E Wagner ◽  
Lena Zobel ◽  
Maximilian Joachim Gerhardt ◽  
Catherine R O'Riordan ◽  
Amy Frederick ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Mouse Model ◽  
Retinitis Pigmentosa ◽  
Knockout Mouse ◽  
Knockout Mouse Model
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