scholarly journals Antibody-dependent enhancement of dengue virus infection inhibits RLR-mediated Type-I IFN-independent signalling through upregulation of cellular autophagy

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Xinwei Huang ◽  
Yaofei Yue ◽  
Duo Li ◽  
Yujiao Zhao ◽  
Lijuan Qiu ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Type I ◽  
Type I Ifn ◽  
Dengue Virus Infection ◽  
Antibody Dependent Enhancement ◽  
Cellular Autophagy

scholarly journals Current Understanding of the Pathogenesis of Dengue Virus Infection

2020 ◽  
Author(s):  
Puneet Bhatt ◽  
Sasidharan Pillai Sabeena ◽  
Muralidhar Varma ◽  
Govindakarnavar Arunkumar
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
Genetic Factors ◽  
Host Immune Response ◽  
Severe Dengue ◽  
Ns1 Protein ◽  
Dengue Virus Infection ◽  
Antibody Dependent Enhancement

AbstractThe pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility. NS1 protein and anti-DENV NS1 antibodies were believed to be responsible for pathogenesis of severe dengue. The cytokine response of cross-reactive CD4+ T cells might be altered by the sequential infection with different DENV serotypes, leading to further elevation of pro-inflammatory cytokines contributing a detrimental immune response. Fcγ receptor-mediated antibody-dependent enhancement (ADE) results in release of cytokines from immune cells leading to vascular endothelial cell dysfunction and increased vascular permeability. Genomic variation of dengue virus and subgenomic flavivirus RNA (sfRNA) suppressing host immune response are viral determinants of disease severity. Dengue infection can lead to the generation of autoantibodies against DENV NS1antigen, DENV prM, and E proteins, which can cross-react with several self-antigens such as plasminogen, integrin, and platelet cells. Apart from viral factors, several host genetic factors and gene polymorphisms also have a role to play in pathogenesis of DENV infection. This review article highlights the various factors responsible for the pathogenesis of dengue and also highlights the recent advances in the field related to biomarkers which can be used in future for predicting severe disease outcome.

Antibody-dependent enhancement of dengue virus infection is inhibited by SA-17, a doxorubicin derivative

2013 ◽  
Vol 100 (1) ◽  
pp. 238-245 ◽  
Author(s):  
Nilda V. Ayala-Nuñez ◽  
Patsaporn Jarupathirun ◽  
Suzanne J.F. Kaptein ◽  
Johan Neyts ◽  
Jolanda M. Smit
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Virus Infection ◽  
Antibody Dependent Enhancement

scholarly journals Cell Type Specificity and Host Genetic Polymorphisms Influence Antibody-Dependent Enhancement of Dengue Virus Infection

2010 ◽  
Vol 85 (4) ◽  
pp. 1671-1683 ◽  
Author(s):  
K. Boonnak ◽  
K. M. Dambach ◽  
G. C. Donofrio ◽  
B. Tassaneetrithep ◽  
M. A. Marovich
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Genetic Polymorphisms ◽  
Cell Type ◽  
Cell Type Specificity ◽  
Dengue Virus Infection ◽  
Antibody Dependent Enhancement ◽  
Host Genetic

scholarly journals Antibody-dependent enhancement of dengue virus infection in U937 cells requires cholesterol-rich membrane microdomains

2009 ◽  
Vol 91 (2) ◽  
pp. 394-403 ◽  
Author(s):  
H. Puerta-Guardo ◽  
C. Mosso ◽  
F. Medina ◽  
F. Liprandi ◽  
J. E. Ludert ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Membrane Microdomains ◽  
U937 Cells ◽  
Dengue Virus Infection ◽  
Antibody Dependent Enhancement

Antibody-dependent enhancement of dengue virus infection

1991 ◽  
Vol 1 (4) ◽  
pp. 211-221 ◽  
Author(s):  
I. Kurane ◽  
B. J. Mady ◽  
F. A. Ennis
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Virus Infection ◽  
Antibody Dependent Enhancement

scholarly journals The inhibiting effect of the transcription factor p53 on dengue virus infection by activating the type I interferon

Oncotarget ◽  
2017 ◽  
Vol 8 (15) ◽  
pp. 25151-25157 ◽  
Author(s):  
Yan-Ling Hu ◽  
Xiao-Shan Li ◽  
Shu Xiong ◽  
Qiang Ma ◽  
Dan Liu ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Virus Infection ◽  
Dengue Virus ◽  
Type I Interferon ◽  
Type I ◽  
Dengue Virus Infection ◽  
Inhibiting Effect ◽  
Transcription Factor P53
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