scholarly journals Synergistic Effect of Cold Atmospheric Plasma and Drug Loaded Core-shell Nanoparticles on Inhibiting Breast Cancer Cell Growth

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Wei Zhu ◽  
Se-Jun Lee ◽  
Nathan J. Castro ◽  
Dayun Yan ◽  
Michael Keidar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Synergistic Effect ◽  
Atmospheric Plasma ◽  
Core Shell ◽  
Cancer Cell Growth ◽  
Shell Nanoparticles ◽  
Cold Atmospheric Plasma ◽  
Breast Cancer Cell Growth ◽  
Core Shell Nanoparticles

scholarly journals Cold Atmospheric Plasma Attenuates Breast Cancer Cell Growth Through Regulation of Cell Microenvironment Effectors

2022 ◽  
Vol 11 ◽  
Author(s):  
Christos A. Aggelopoulos ◽  
Anna-Maria Christodoulou ◽  
Myrsini Tachliabouri ◽  
Stauros Meropoulis ◽  
Maria-Elpida Christopoulou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Atmospheric Plasma ◽  
Stem Cell Marker ◽  
Cancer Cell Growth ◽  
Cold Atmospheric Plasma ◽  
Breast Cancer Cell Growth ◽  
The Impact

Breast cancer exists in multiple subtypes some of which still lack a targeted and effective therapy. Cold atmospheric plasma (CAP) has been proposed as an emerging anti-cancer treatment modality. In this study, we investigated the effects of direct and indirect CAP treatment driven by the advantageous nanosecond pulsed discharge on breast cancer cells of different malignant phenotypes and estrogen receptor (ER) status, a major factor in the prognosis and therapeutic management of breast cancer. The main CAP reactive species in liquid (i.e. H2O2, NO2−/NO3−) and gas phase were determined as a function of plasma operational parameters (i.e. treatment time, pulse voltage and frequency), while pre-treatment with the ROS scavenger NAC revealed the impact of ROS in the treatment. CAP treatment induced intense phenotypic changes and apoptosis in both ER+ and ER- cells, which is associated with the mitochondrial pathway as evidenced by the increased Bax/Bcl-2 ratio and cleavage of PARP-1. Interestingly, CAP significantly reduced CD44 protein expression (a major cancer stem cell marker and matrix receptor), while differentially affected the expression of proteases and inflammatory mediators. Collectively, the findings of the present study suggest that CAP suppresses breast cancer cell growth and regulates several effectors of the tumor microenvironment and thus it could represent an efficient therapeutic approach for distinct breast cancer subtypes.

scholarly journals Knockdown of Mgat5 Inhibits Breast Cancer Cell Growth with Activation of CD4+ T Cells and Macrophages

2008 ◽  
Vol 180 (5) ◽  
pp. 3158-3165 ◽  
Author(s):  
Dongqing Li ◽  
Yanmei Li ◽  
Xianglei Wu ◽  
Qiao Li ◽  
Jing Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cd4 T Cells ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G2 /M arrest and apoptosis

2011 ◽  
Vol 52 (2) ◽  
pp. 134-143 ◽  
Author(s):  
Jixia Li ◽  
Feng Zhu ◽  
Ronald A. Lubet ◽  
Antonella De Luca ◽  
Clinton Grubbs ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Methyl Ether ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Resistant Breast Cancer Cell

scholarly journals Differential Roles of Fibroblast Growth Factor Receptors (FGFR) 1, 2 and 3 in the Regulation of S115 Breast Cancer Cell Growth

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49970 ◽  
Author(s):  
Kati M. Tarkkonen ◽  
Emeli M. Nilsson ◽  
Tiina E. Kähkönen ◽  
Julien H. Dey ◽  
Jari E. Heikkilä ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cell Growth ◽  
Fibroblast Growth Factor ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Receptors ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals Oolong Tea Extract Induces DNA Damage and Cleavage and Inhibits Breast Cancer Cell Growth and Tumorigenesis

2018 ◽  
Vol 38 (11) ◽  
pp. 6217-6223
Author(s):  
HAIHONG SHI ◽  
JIN LIU ◽  
YIFAN TU ◽  
CARL E. FRETER ◽  
CHUNFA HUANG
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Oolong Tea ◽  
Tea Extract
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