scholarly journals Simultaneous knockdown of uPA and MMP9 can reduce breast cancer progression by increasing cell-cell adhesion and modulating EMT genes

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Anuradha Moirangthem ◽  
Banashree Bondhopadhyay ◽  
Mala Mukherjee ◽  
Arghya Bandyopadhyay ◽  
Narendranath Mukherjee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Cell Cell

scholarly journals Tight Junctions: A Barrier to the Initiation and Progression of Breast Cancer?

2010 ◽  
Vol 2010 ◽  
pp. 1-16 ◽  
Author(s):  
Kieran Brennan ◽  
Gozie Offiah ◽  
Elaine A. McSherry ◽  
Ann M. Hopkins
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Epithelial Cells ◽  
Cell Fate ◽  
Cancer Progression ◽  
Protein Composition ◽  
Normal Structure ◽  
Breast Cancer Progression ◽  
And Function ◽  
Cell Cell

Breast cancer is a complex and heterogeneous disease that arises from epithelial cells lining the breast ducts and lobules. Correct adhesion between adjacent epithelial cells is important in determining the normal structure and function of epithelial tissues, and there is accumulating evidence that dysregulated cell-cell adhesion is associated with many cancers. This review will focus on one cell-cell adhesion complex, the tight junction (TJ), and summarize recent evidence that TJs may participate in breast cancer development or progression. We will first outline the protein composition of TJs and discuss the functions of the TJ complex. Secondly we will examine how alterations in these functions might facilitate breast cancer initiation or progression; by focussing on the regulatory influence of TJs on cell polarity, cell fate and cell migration. Finally we will outline how pharmacological targeting of TJ proteins may be useful in limiting breast cancer progression. Overall we hope to illustrate that the relationship between TJ alterations and breast cancer is a complex one; but that this area offers promise in uncovering fundamental mechanisms linked to breast cancer progression.

scholarly journals Early Dysregulation of Cell Adhesion and Extracellular Matrix Pathways in Breast Cancer Progression

2009 ◽  
Vol 175 (3) ◽  
pp. 1292-1302 ◽  
Author(s):  
Lyndsey A. Emery ◽  
Anusri Tripathi ◽  
Chialin King ◽  
Maureen Kavanah ◽  
Jane Mendez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Cell Adhesion ◽  
Cancer Progression ◽  
Breast Cancer Progression

Beta haemoglobin (hbb) is a novel marker of breast cancer progression

2014 ◽  
Author(s):  
Mattia Capulli ◽  
Adriano Angelucci ◽  
Anna Teti ◽  
Patrizia Sanita ◽  
Luca Ventura ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Breast Cancer Progression
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