scholarly journals Sonic hedgehog stimulates neurite outgrowth in a mechanical stretch model of reactive-astrogliosis

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Antonio Berretta ◽  
Emma K. Gowing ◽  
Christine L. Jasoni ◽  
Andrew N. Clarkson
Keyword(s):  
Neurite Outgrowth ◽  
Sonic Hedgehog ◽  
Mechanical Stretch ◽  
Reactive Astrogliosis

Sonic Hedgehog Promotes Neurite Outgrowth of Primary Cortical Neurons Through Up-Regulating BDNF Expression

2015 ◽  
Vol 41 (4) ◽  
pp. 687-695 ◽  
Author(s):  
Weiliang He ◽  
Lili Cui ◽  
Cong Zhang ◽  
Xiangjian Zhang ◽  
Junna He ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Sonic Hedgehog ◽  
Cortical Neurons ◽  
Bdnf Expression ◽  
Primary Cortical Neurons

scholarly journals Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth

2006 ◽  
Vol 298 (1) ◽  
pp. 167-175 ◽  
Author(s):  
Po-Lin So ◽  
Ping K. Yip ◽  
Stephen Bunting ◽  
Liang-Fong Wong ◽  
Nicholas D. Mazarakis ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neurite Outgrowth ◽  
Sonic Hedgehog ◽  
Signalling Pathways ◽  
Hedgehog Signalling ◽  
Nerve Growth ◽  
Sonic Hedgehog Signalling

A Sonic hedgehog coreceptor, BOC regulates neuronal differentiation and neurite outgrowth via interaction with ABL and JNK activation

2017 ◽  
Vol 30 ◽  
pp. 30-40 ◽  
Author(s):  
Tuan Anh Vuong ◽  
Young-Eun Leem ◽  
Bok-Geon Kim ◽  
Hana Cho ◽  
Sang-Jin Lee ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Neuronal Differentiation ◽  
Sonic Hedgehog ◽  
Jnk Activation

scholarly journals Resveratrol Enhances Neurite Outgrowth and Synaptogenesis Via Sonic Hedgehog Signaling Following Oxygen-Glucose Deprivation/Reoxygenation Injury

2017 ◽  
Vol 43 (2) ◽  
pp. 852-869 ◽  
Author(s):  
Fanren Tang ◽  
Shuang Guo ◽  
Hongyan Liao ◽  
Pingping Yu ◽  
Li Wang ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Glucose Deprivation ◽  
Underlying Mechanism ◽  
Cell Counting ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Oxygen Glucose Deprivation ◽  
Shh Signaling ◽  
Gli 1

Background/Aims: Neurite outgrowth and synaptogenesis are critical steps for functional recovery after stroke. Resveratrol promotes neurite outgrowth and synaptogenesis, but the underlying mechanism is not well understood, although the Sonic hedgehog (Shh) signaling pathway may be involved. Given that resveratrol activates sirtuin (Sirt)1, the present study examined whether this is mediated by Shh signaling. Methods: Primary cortical neuron cultures were pretreated with drugs before oxygen-glucose deprivation/reoxygenation (OGD/R). Cell viability and apoptosis were evaluated with Cell Counting Kit 8 and by terminal deoxynucleotidyl transferase dUTP nick end labeling, respectively. Neurite outgrowth and synaptogenesis were assessed by immunocytochemistry and western blotting, which was also used to examine the expression of Sirt1 and Shh signaling proteins. Results: Resveratrol and the Smoothened (Smo) agonist purmophamine, which activates Shh signaling, increased viability, reduced apoptosis, and stimulated neurite outgrowth after OGD/R injury. Moreover, the expression of growth-associated protein(GAP)-43, synaptophysin, Shh, Patched (Ptc)-1, Smo, glioma-associated oncogene homolog (Gli)-1, and Sirt1 were upregulated under these conditions. These effects were reversed by treatment with the Smo inhibitor cyclopamine, whereas the Sirt1 inhibitor sirtinol reduced the levels of Shh, Ptc-1, Smo, and Gli-1. Conclusions: Resveratrol reduces neuronal injury following OGD/R injury and enhances neurite outgrowth and synaptogenesis by activating Shh signaling, which in turn induces Sirt1.

Sonic hedgehog promotes neurite outgrowth of cortical neurons under oxidative stress: Involving of mitochondria and energy metabolism

2017 ◽  
Vol 350 (1) ◽  
pp. 83-90 ◽  
Author(s):  
Weiliang He ◽  
Lili Cui ◽  
Cong Zhang ◽  
Xiangjian Zhang ◽  
Junna He ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Energy Metabolism ◽  
Neurite Outgrowth ◽  
Sonic Hedgehog ◽  
Cortical Neurons

672: Regulation of Cavernous Nerve Injury-Induced Apoptosis by Sonic Hedgehog

2007 ◽  
Vol 177 (4S) ◽  
pp. 225-225
Author(s):  
Carol A. Podlasek ◽  
Yi Tang ◽  
Cynthia L. Meraz ◽  
Kevin E. McKenna ◽  
Kevin T. McVary
Keyword(s):  
Nerve Injury ◽  
Sonic Hedgehog ◽  
Cavernous Nerve ◽  
Induced Apoptosis ◽  
Cavernous Nerve Injury
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