scholarly journals Gene expression profiling of white adipose tissue reveals paternal transmission of proneness to obesity

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Sumiyo Morita ◽  
Kazuhiko Nakabayashi ◽  
Tomoko Kawai ◽  
Keiko Hayashi ◽  
Takuro Horii ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Gene Expression Profiling ◽  
White Adipose Tissue ◽  
Expression Profiling ◽  
Paternal Transmission

scholarly journals Gene expression profiling identifies liver X receptor alpha as an estrogen-regulated gene in mouse adipose tissue

2004 ◽  
Vol 32 (3) ◽  
pp. 879-892 ◽  
Author(s):  
L Lundholm ◽  
S Moverare ◽  
KR Steffensen ◽  
M Nilsson ◽  
M Otsuki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Gene Expression Profiling ◽  
White Adipose Tissue ◽  
Expression Profiling ◽  
Liver X Receptor ◽  
Atp Binding ◽  
Mrna Levels ◽  
Ovariectomized Mice ◽  
Atp Binding Cassette

Estrogens reduce adipose tissue mass in both humans and animals. The molecular mechanisms for this effect are, however, not well characterized. We took a gene expression profiling approach to study the direct effects of estrogen on mouse white adipose tissue (WAT). Female ovariectomized mice were treated for 10, 24 and 48 h with 17beta-estradiol or vehicle. RNA was extracted from gonadal fat and hybridized to Affymetrix MG-U74Av2 arrays. 17beta-Estradiol was shown to decrease mRNA expression of liver X receptor (LXR) alpha after 10 h of treatment compared with the vehicle control. The expression of several LXRalpha target genes, such as sterol regulatory element-binding protein 1c, apolipoprotein E, phospholipid transfer protein, ATP-binding cassette A1 and ATP-binding cassette G1, was similarly decreased. We furthermore identified a 1.5 kb LXRalpha promoter fragment that is negatively regulated by estrogen. Several genes involved in lipogenesis and lipolysis were identified as novel targets that could mediate estrogenic effects on adipose tissue. Finally, we show that ERalpha is the main estrogen receptor expressed in mouse white adipose tissue (WAT) with mRNA levels several hundred times higher than those of ERbeta mRNA.

Gene expression profiling of gluteal adipose tissue after prolonged bedrest

2018 ◽  
Vol 275 ◽  
pp. e77
Author(s):  
R. Colonna ◽  
E. Dalla Nora ◽  
J.M. Sanz ◽  
M.A. Miselli ◽  
M.L. Morieri ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Gene Expression Profiling ◽  
Expression Profiling

Gene expression profiling of gluteal adipose tissue after prolonged bedrest

2017 ◽  
Vol 27 (1) ◽  
pp. e15-e16
Author(s):  
R. Colonna ◽  
M.A. Miselli ◽  
J.M. Sanz ◽  
E. Dalla Nora ◽  
G. Zuliani ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Gene Expression Profiling ◽  
Expression Profiling
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