scholarly journals Dynamic nuclear polarization-magnetic resonance imaging at low ESR irradiation frequency for ascorbyl free radicals

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Shinji Ito ◽  
Fuminori Hyodo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Free Radicals ◽  
Magnetic Resonance ◽  
Dynamic Nuclear Polarization ◽  
Nuclear Polarization ◽  
Resonance Imaging ◽  
Irradiation Frequency

scholarly journals Metabolic contrast agents produced from transported solid 13C-glucose hyperpolarized via dynamic nuclear polarization

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Andrea Capozzi ◽  
Jan Kilund ◽  
Magnus Karlsson ◽  
Saket Patel ◽  
Arthur Cesar Pinon ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Dynamic Nuclear Polarization ◽  
Nuclear Polarization ◽  
Magnetic Resonance Signal ◽  
Resonance Imaging ◽  
End User ◽  
Resonance Signal ◽  
Sample Extraction

AbstractMagnetic Resonance Imaging combined with hyperpolarized 13C-labelled metabolic contrast agents produced via dissolution Dynamic Nuclear Polarization can, non-invasively and in real-time, report on tissue specific aberrant metabolism. However, hyperpolarization equipment is expensive, technically demanding and needs to be installed on-site for the end-user. In this work, we provide a robust methodology that allows remote production of the hyperpolarized 13C-labelled metabolic contrast agents. The methodology, built on photo-induced thermally labile radicals, allows solid sample extraction from the hyperpolarization equipment and several hours’ lifetime of the 13C-labelled metabolic contrast agents at appropriate storage/transport conditions. Exemplified with [U-13C, d7]-D-glucose, we remotely produce hyperpolarized 13C-labelled metabolic contrast agents and generate above 10,000-fold liquid-state Magnetic Resonance signal enhancement at 9.4 T, keeping on-site only a simple dissolution device.

Sign in / Sign up

Export Citation Format

Share Document