scholarly journals Effects of TRP channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Stéphanie Michlig ◽  
Jenny Meylan Merlini ◽  
Maurice Beaumont ◽  
Mirko Ledda ◽  
Aude Tavenard ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Randomized Clinical Trial ◽  
Healthy Subjects ◽  
Trp Channel ◽  
Autonomic Nervous ◽  
Channel Agonist

scholarly journals Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Daniel Noronha Osório ◽  
Ricardo Viana-Soares ◽  
João Pedro Marto ◽  
Marcelo D. Mendonça ◽  
Hugo P. Silva ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Healthy Subjects ◽  
System Response ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning ◽  
Autonomic Nervous ◽  
Non Linear

Abstract Background Remote ischemic conditioning (RIC) is a procedure applied in a limb for triggering endogenous protective pathways in distant organs, namely brain or heart. The underlying mechanisms of RIC are still not fully understood, and it is hypothesized they are mediated either by humoral factors, immune cells and/or the autonomic nervous system. Herein, heart rate variability (HRV) was used to evaluate the electrophysiological processes occurring in the heart during RIC and, in turn to assess the role of autonomic nervous system. Methods Healthy subjects were submitted to RIC protocol and electrocardiography (ECG) was used to evaluate HRV, by assessing the variability of time intervals between two consecutive heart beats. This is a pilot study based on the analysis of 18 ECG from healthy subjects submitted to RIC. HRV was characterized in three domains (time, frequency and non-linear features) that can be correlated with the autonomic nervous system function. Results RIC procedure increased significantly the non-linear parameter SD2, which is associated with long term HRV. This effect was observed in all subjects and in the senior (> 60 years-old) subset analysis. SD2 increase suggests an activation of both parasympathetic and sympathetic nervous system, namely via fast vagal response (parasympathetic) and the slow sympathetic response to the baroreceptors stimulation. Conclusions RIC procedure modulates both parasympathetic and sympathetic autonomic nervous system. Furthermore, this modulation is more pronounced in the senior subset of subjects. Therefore, the autonomic nervous system regulation could be one of the mechanisms for RIC therapeutic effectiveness.

scholarly journals Can we Modulate the Autonomic Nervous System to Improve the Life of Patients with Heart Failure? The Case of Vagal Stimulation

2014 ◽  
Vol 3 (2) ◽  
pp. 120
Author(s):  
Peter J Schwartz ◽  
Keyword(s):  
Heart Failure ◽  
Clinical Trial ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Vagal Stimulation ◽  
Safety Data ◽  
Experimental Studies ◽  
Autonomic Nervous ◽  
The Right ◽  
Exciting Possibility

An imbalance of the autonomic nervous system, with reduced vagal and increased sympathetic activity, contributes to pathogenesis and clinical deterioration in heart failure (HF). Experimental studies have demonstrated that vagal stimulation (VS) has an antifibrillatory effect that has proved beneficial in animal models of HF. The potential value of chronic VS in man was first investigated with an implantable neuro-stimulator capable of delivering low current pulses with adjustable parameters to stimulate the right vagus. The results of a pilot study and a small multicentre clinical trial of VS in HF patients appeared to show a favourable clinical effect, and feasibility and safety data were encouraging. An ongoing pivotal clinical trial will provide a definitive assessment of the efficacy and usefulness of chronic VS in HF patients.This approach represents a new and exciting possibility for the management of HF that will provide clinicians with a novel tool to modulate non-pharmacologically the autonomic nervous system in patients with moderate-to-advanced HF.

scholarly journals Fractals disruption as the footprint of subthreshold depressive symptoms on the heart rate

2021 ◽  
Author(s):  
Piergiorgio mandarano ◽  
Paolo Ossola ◽  
Maria Carsillo ◽  
Pierluca Marazzi ◽  
Stefano Rozzi ◽  
...  
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Depressive Symptoms ◽  
Autonomic Nervous System ◽  
Healthy Subjects ◽  
Smoking Habit ◽  
Heart Rhythm ◽  
Low Frequencies ◽  
Autonomic Nervous ◽  
Diagnostic Threshold

Psychopathology, and in particular depression, is a cardiovascular risk factor independent from co-occurring pathology. This link is traced back to the mind-heart-body connection, whose underlying mechanisms are, to date, not completely known. It is clear, however, that the autonomic nervous system plays a leading role in the mediation between the parts of that connection. Therefore, to study psychopathology in relation to the heart, it is necessary to observe the autonomic nervous system, whose gold standard of evaluation is the study of heart rate variability (HRV). Two short-term HRV recordings (5 min - supine and sitting) were analysed in 77 healthy subjects. Here we adopted a three-fold approach to evaluate HRV: a set of scores belonging to the time domain (SDNN, pNN50, RMSSD); the frequency analyses that gauges three main components (high, low, and very low frequencies) and a new set of complexity nonlinear parameters. The PHQ-9 scale was used to detect depressive symptoms. Depressive symptoms were associated only with a parameter from the non-linear approach and specifically the long-term fluctuations of fractal dimensions (DFA-α2). This association remained significant even after controlling for age, gender, BMI, arterial hypertension, anti-hypertensive drugs, dyslipidaemia, and smoking habit. Moreover, the DFA-α2 was not affected by the baroreflex (postural change), unlike other autonomic markers. In conclusion, fractal analysis of HRV (DFA-α2) allows to predict depressive symptoms below diagnostic threshold in healthy subjects regardless of their health status. DFA-α2 may be then considered as an imprint of subclinical depression on the heart rhythm.

Sign in / Sign up

Export Citation Format

Share Document