scholarly journals The promoter methylomes of monochorionic twin placentas reveal intrauterine growth restriction-specific variations in the methylation patterns

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Zhiming He ◽  
Hanlin Lu ◽  
Huijuan Luo ◽  
Fei Gao ◽  
Tong Wang ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Monochorionic Twin ◽  
Intrauterine Growth ◽  
Methylation Patterns

Outcome of monochorionic twin pregnancy complicated by Type‐III selective intrauterine growth restriction

2021 ◽  
Vol 57 (1) ◽  
pp. 126-133
Author(s):  
S. Shinar ◽  
W. Xing ◽  
V. Pruthi ◽  
C. Jianping ◽  
F. Slaghekke ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Twin Pregnancy ◽  
Growth Restriction ◽  
Monochorionic Twin ◽  
Intrauterine Growth ◽  
Type Iii

scholarly journals Monochorionic twin pregnancies increases perinatal risk and is a high risk factor of selective intrauterine growth restriction

2019 ◽  
Author(s):  
Jie Chen ◽  
Yue Lian Yang
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
High Risk ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Prenatal Health ◽  
Monochorionic Twin ◽  
Intrauterine Growth ◽  
High Risk Factor ◽  
Twin Pregnancies

Abstract Background Twins pregnancy can cause a lot of disease, especially monochorionic twin pregnancies, the prenatal infant will have many diseases and have high mortality rate. According to analysis and compare of the twin pregnancy, especially pregnant woman and puerpera’s situation and complication and baby’s situation; we hope we can find the reason which causes the fetus growth restrain of monochorionic twin pregnancies. So we can provide some reference for the prenatal health care, complication prevention and prenatal outcome. Methods We divided 489 cases of twin pregnancies into two groups: monochorionic twin and dichorionic twin and compared the clinical features of them. At last, we used the logistic regression analysis method to analyze the risk factors of selective intrauterine growth restriction(sIUGR). Results The incidences of premature rupture of membranes and sIUGR were significant higher in monochorionic twin and twin-twin transfusion syndrome (TTTS) only exists in monochorionic twin. The weight of the newborn babies(both big and small babies)were significant lower in Monochorionic twin. The neonatal transfer rate was significant higher in monochorionic twin. Gestational weeks and weight of newborn babies are the high risk factors of sIUGR. Conclusions The type of chorion has a great influence to the pregnant period and the ending of maternal women. Monochorionic is a high risk factor of the sIUGR, which means that the main cause of sIUGR is from placenta, so it is a kind of “placental origin disease”.

scholarly journals Right Ventricular Outflow Tract Obstruction in Monochorionic Twins with Selective Intrauterine Growth Restriction

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
S. B. de Haseth ◽  
M. C. Haak ◽  
A. A. W. Roest ◽  
M. E. B. Rijlaarsdam ◽  
D. Oepkes ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Intrauterine Growth Restriction ◽  
Right Ventricular Outflow Tract ◽  
Ventricular Outflow Tract ◽  
Outflow Tract ◽  
Growth Restriction ◽  
Monochorionic Twins ◽  
Monochorionic Twin ◽  
Intrauterine Growth ◽  
Ventricular Outflow Tract Obstruction

Monochorionic twin pregnancies are at increased risk of perinatal mortality and morbidity due to twin-twin transfusion syndrome (TTTS), selective intrauterine growth restriction (sIUGR), and higher incidence of congenital heart malformations. The incidence of right ventricular outflow tract obstruction (RVOTO) in recipients with TTTS is known to be higher than in the general population. There is limited data on the risk of RVOTO in monochorionic twins with sIUGR. We report a case of RVOTO in the larger twin in a monochorionic twin pregnancy with sIUGR, treated successfully with balloon dilatation after birth.

scholarly journals The comparison of the perinatal outcomes in monochorionic twin pregnancies with and without selective intrauterine growth restriction

2021 ◽  
Vol 29 (1) ◽  
pp. 20-26
Author(s):  
Elif Fide Pişirgen ◽  
Münip Akalın ◽  
Oya Demirci ◽  
Pınar Kumru ◽  
Emine Eda Akalın
Keyword(s):  
Flow Pattern ◽  
Intrauterine Growth Restriction ◽  
Umbilical Artery ◽  
Perinatal Outcomes ◽  
Growth Restriction ◽  
Monochorionic Twin ◽  
Intrauterine Growth ◽  
Increased Risk ◽  
Artery Flow ◽  
Twin Pregnancies

Objective Both fetuses may be affected negatively as a result of the non-equal share of the placenta and vascular anastomoses in monochorionic pregnancies with selective intrauterine growth restriction (sIUGR). In our study, we aimed to investigate the perinatal outcomes of both larger and smaller fetuses in monochorionic pregnancies with and without sIUGR (non-sIUGR) separately. Methods A total of 196 monochorionic twin pregnancies were evaluated retrospectively between January 2013 and January 2019. The cases were grouped as sIUGR and non-sIUGR pregnancies. The pregnancies with sIUGR were also separated into sub-groups as the cases with normal umbilical flow pattern and the cases with abnormal umbilical flow pattern. The perinatal outcomes were investigated separately between the groups for larger and smaller fetuses. Results Of 153 monochorionic pregnancies included in the study, 17.6% (n=27) were sIUGR cases and 82.4% (n=126) were non-sIUGR cases. While the umbilical artery flow pattern was normal in 59.3% (n=16) of the pregnancies which developed sIUGR, 40.7% (n=11) of them had abnormal umbilical artery flow pattern. The preeclampsia rate was found significantly higher in sIUGR pregnancies than non-sIUGR pregnancies (25.9% vs. 11.1%, p=0.042). The need for intensive care for both larger and smaller newborns was significantly higher in sIUGR pregnancies compared to non-sIUGR pregnancies (p<0.001). Three (11.1%) of newborns in sIUGR pregnancies passed away during neonatal period. All of the newborns that passed away were the smaller newborns from sIUGR pregnancies with abnormal umbilical artery flow pattern. Conclusion The pregnancies with selective intrauterine growth restriction (sIUGR) are more associated with high risks in terms of perinatal outcomes compared to the pregnancies with non-sIUGR. In pregnancies developing sIUGR, the risk increases for larger fetus as well as smaller fetus. More prospective studies are needed to investigate whether this increased risk in the pregnancies with sIUGR is associated with prematurity which is more common or is a result of sIUGR.

The Relationships of Umbilical Venous Volume Flow, Birthweight and Placental Share in Monochorionic Twin Pregnancies With and Without Selective Intrauterine Growth Restriction

2011 ◽  
Vol 14 (2) ◽  
pp. 192-197 ◽  
Author(s):  
Yao-lung Chang ◽  
Shuenn-dyh Chang ◽  
An-shine Chao ◽  
Chao-nin Wang ◽  
Tzu-hao Wang ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Volume Flow ◽  
Growth Restriction ◽  
Intrauterine Fetal Death ◽  
Maximal Velocity ◽  
Monochorionic Twins ◽  
Monochorionic Twin ◽  
Intrauterine Growth ◽  
Venous Volume ◽  
Twin Pregnancies

This study was conducted to investigate the relationship among umbilical venous volume flow, birthweight and placental share in monochorionic twins with or without selective growth restriction. Having excluded cases complicated with twin-to-twin transfusion syndrome and one co-twin suffering intrauterine fetal death, a total of 51 monochorionic twin pregnancies were divided into two groups as with (group 1) and without (group 2) selective intrauterine growth restriction. Umbilical venous volume flow was calculated by multiplying the umbilical vein cross-sectional area by half of the maximal velocity around mid-trimester. The placentas were cut along the vascular equator into two individual placental masses. The discordance of birthweight was calculated as [(birthweight of larger twin—birthweight of smaller twin)/birthweight of larger twin 100%]. The discordances of umbilical venous volume flow and placental share were calculated in a similar fashion. The median umbilical venous volume flow discordances (68.4% and 15.3% in groups 1 and 2 monochorionic twins, respectively) were similar and correlated well with the placental share discordances (66.6% and 18.5% in groups 1 and 2 monochorionic twins, respectively) but not with the birthweight discordance (28.6% and 6.4% in groups 1 and 2 monochorionic twins, respectively) in both groups. We concluded that the umbilical venous volume flow discordance reflects the placental share discordance rather than the birthweight discordance in monochorionic twin pregnancies.

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