scholarly journals In vivo articular cartilage deformation: noninvasive quantification of intratissue strain during joint contact in the human knee

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Deva D. Chan ◽  
Luyao Cai ◽  
Kent D. Butz ◽  
Stephen B. Trippel ◽  
Eric A. Nauman ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Human Knee ◽  
Joint Contact

scholarly journals Articular Cartilage of the Human Knee Joint: In Vivo Multicomponent T2 Analysis at 3.0 T

Radiology ◽  
2015 ◽  
Vol 277 (2) ◽  
pp. 477-488 ◽  
Author(s):  
Fang Liu ◽  
Kwang Won Choi ◽  
Alexey Samsonov ◽  
Richard G. Spencer ◽  
John J. Wilson ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Human Knee ◽  
Human Knee Joint ◽  
3.0 T

Effect of Joint Center Location on In-Vivo Joint Contact Forces During Walking

2010 ◽  
Author(s):  
Yoon-Hyuk Kim ◽  
Won-Man Park ◽  
Bui Thi Thanh Phuong
Keyword(s):  
Articular Cartilage ◽  
Joint Arthroplasty ◽  
Contact Forces ◽  
Implant Design ◽  
Muscle Forces ◽  
Joint Contact ◽  
Joint Center ◽  
Muscular Coordination ◽  
Accurate Quantification

Estimation of in-vivo joint contact forces and muscle forces during walking is important in order to protect the knee joint from injury or provide adequate rehabilitation and exercise protocols [1]. Assessment of muscle forces can help to understand the neuro-muscular coordination related on neurological problems [2]. Accurate quantification of joint contact forces can help to characterize the contact phenomena of articular cartilage at the joint related on osteoarthritis and to improve the implant design for the longevity of joint arthroplasty [3].

In vivo characterization of indentation stiffness of articular cartilage in the normal human knee

1999 ◽  
Vol 48 (4) ◽  
pp. 482-487 ◽  
Author(s):  
Tiina Lyyra ◽  
Ilkka Kiviranta ◽  
Urho V��t�inen ◽  
Heikki J. Helminen ◽  
Jukka S. Jurvelin
Keyword(s):  
Articular Cartilage ◽  
Human Knee ◽  
Normal Human ◽  
In Vivo Characterization

scholarly journals Isotropic morphometry and multicomponent T1ρ mapping of human knee articular cartilage in vivo at 3T

2018 ◽  
Vol 48 (6) ◽  
pp. 1707-1716 ◽  
Author(s):  
Rahman Baboli ◽  
Azadeh Sharafi ◽  
Gregory Chang ◽  
Ravinder R. Regatte
Keyword(s):  
Articular Cartilage ◽  
Human Knee ◽  
T1ρ Mapping

Physiological assessment of in vivo human knee articular cartilage using sodium MR imaging at 1.5T

2013 ◽  
Vol 31 (7) ◽  
pp. 1059-1067 ◽  
Author(s):  
Ahmad Fadzil Mohd Hani ◽  
Dileep Kumar ◽  
Aamir Saeed Malik ◽  
Ruslan Razak
Keyword(s):  
Articular Cartilage ◽  
Mr Imaging ◽  
Human Knee ◽  
Physiological Assessment

Experimentally Applied Mechanical Load to the Human Knee Systematically Affects the Morphology of Articular Cartilage

2018 ◽  
Author(s):  
Grischa Bratke ◽  
Steffen Willwacher ◽  
David Maintz ◽  
Gert-Peter Brüggemann
Keyword(s):  
Articular Cartilage ◽  
Mechanical Load ◽  
Human Knee

Effects of in vitro low oxygen tension preconditioning of buccal fat pad stem cells on in Vivo articular cartilage tissue repair

Life Sciences ◽  
2021 ◽  
pp. 119728
Author(s):  
Fatemeh Dehghani Nazhvani ◽  
Leila Mohammadi Amirabad ◽  
Arezo Azari ◽  
Hamid Namazi ◽  
Simzar Hosseinzadeh ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Tissue Repair ◽  
Cartilage Tissue ◽  
Low Oxygen ◽  
Fat Pad ◽  
Buccal Fat Pad ◽  
Low Oxygen Tension

scholarly journals Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 902
Author(s):  
Susanne N. Wijesinghe ◽  
Mark A. Lindsay ◽  
Simon W. Jones
Keyword(s):  
Rheumatoid Arthritis ◽  
Articular Cartilage ◽  
Joint Diseases ◽  
Synovial Joint ◽  
Pharmacological Treatments ◽  
In Vivo Models ◽  
Inflammatory Joint Diseases ◽  
Joint Pathology ◽  
Cellular Pathways

Osteoarthritis (OA) and rheumatoid arthritis (RA) are two of the most common chronic inflammatory joint diseases, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. The pathology of both OA and RA involves multiple tissues within the joint, including the synovial joint lining and the bone, as well as the articular cartilage in OA. In this review, we discuss the potential for the development of oligonucleotide therapies for these disorders by examining the evidence that oligonucleotides can modulate the key cellular pathways that drive the pathology of the inflammatory diseased joint pathology, as well as evidence in preclinical in vivo models that oligonucleotides can modify disease progression.

scholarly journals In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and in Vivo Analysis of Its Therapeutic Potential in Osteoarthritis

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 615
Author(s):  
Shang-En Huang ◽  
Erna Sulistyowati ◽  
Yu-Ying Chao ◽  
Bin-Nan Wu ◽  
Zen-Kong Dai ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Inflammatory Responses ◽  
Therapeutic Potential ◽  
Antioxidant Properties ◽  
Serum Levels ◽  
Gene Expressions ◽  
Tnf Α ◽  
Anti Inflammatory

Osteoarthritis is a degenerative arthropathy that is mainly characterized by dysregulation of inflammatory responses. KMUP-1, a derived chemical synthetic of xanthine, has been shown to have anti-inflammatory and antioxidant properties. Here, we aimed to investigate the in vitro anti-inflammatory and in vivo anti-osteoarthritis effects of KMUP-1. Protein and gene expressions of inflammation markers were determined by ELISA, Western blotting and microarray, respectively. RAW264.7 mouse macrophages were cultured and pretreated with KMUP-1 (1, 5, 10 μM). The productions of TNF-α, IL-6, MMP-2 and MMP- 9 were reduced by KMUP-1 pretreatment in LPS-induced inflammation of RAW264.7 cells. The expressions of iNOS, TNF-α, COX-2, MMP-2 and MMP-9 were also inhibited by KMUP-1 pretreatment. The gene expression levels of TNF and COX families were also downregulated. In addition, KMUP-1 suppressed the activations of ERK, JNK and p38 as well as phosphorylation of IκBα/NF-κB signaling pathways. Furthermore, SIRT1 inhibitor attenuated the inhibitory effect of KMUP-1 in LPS-induced NF-κB activation. In vivo study showed that KMUP-1 reduced mechanical hyperalgesia in monoiodoacetic acid (MIA)-induced rats OA. Additionally, KMUP-1 pretreatment reduced the serum levels of TNF-α and IL-6 in MIA-injected rats. Moreover, macroscopic and histological observation showed that KMUP-1 reduced articular cartilage erosion in rats. Our results demonstrated that KMUP-1 inhibited the inflammatory responses and restored SIRT1 in vitro, alleviated joint-related pain and cartilage destruction in vivo. Taken together, KMUP-1 has the potential to improve MIA-induced articular cartilage degradation by inhibiting the levels and expression of inflammatory mediators suggesting that KMUP-1 might be a potential therapeutic agent for OA.

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