scholarly journals PI3K/Akt signaling pathway triggers P2X7 receptor expression as a pro-survival factor of neuroblastoma cells under limiting growth conditions

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Rosa Gómez-Villafuertes ◽  
Paula García-Huerta ◽  
Juan Ignacio Díaz-Hernández ◽  
Mª Teresa Miras-Portugal
Keyword(s):  
Signaling Pathway ◽  
P2x7 Receptor ◽  
Neuroblastoma Cells ◽  
Growth Conditions ◽  
Akt Signaling ◽  
Receptor Expression ◽  
Akt Signaling Pathway ◽  
Survival Factor

Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large B-cell lymphoma

2010 ◽  
Vol 51 (7) ◽  
pp. 1305-1314 ◽  
Author(s):  
Shahab Uddin ◽  
Rong Bu ◽  
Maqbool Ahmed ◽  
Azhar R. Hussain ◽  
Dahish Ajarim ◽  
...  
Keyword(s):  
B Cell ◽  
Signaling Pathway ◽  
Leptin Receptor ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Akt Signaling ◽  
Receptor Expression ◽  
Akt Signaling Pathway ◽  
Large B Cell Lymphoma ◽  
Large B Cell

BAG-1L Protects SH-SY5Y Neuroblastoma Cells Against Hypoxia/Re-oxygenation Through Up-Regulating HSP70 and Activating PI3K/AKT Signaling Pathway

2017 ◽  
Vol 42 (10) ◽  
pp. 2861-2868 ◽  
Author(s):  
Yun Wang ◽  
Chao Jia ◽  
Qing-Shu Li ◽  
Chun-Yu Xie ◽  
Nan Zhang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Neuroblastoma Cells ◽  
Akt Signaling ◽  
Akt Signaling Pathway

Lack of correlation between leptin receptor expression and PI3-K/Akt signaling pathway proteins immunostaining in endometrioid-type endometrial carcinomas

2006 ◽  
Vol 238 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Michał Bogusiewicz ◽  
Andrzej Semczuk ◽  
Marek Gogacz ◽  
Danuta Skomra ◽  
Jerzy A. Jakowicki ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Leptin Receptor ◽  
Akt Signaling ◽  
Receptor Expression ◽  
Akt Signaling Pathway ◽  
Endometrial Carcinomas

Biological role of AKT, and regulation of AKT signaling pathway by thymoquinone: perspectives in cancer therapeutics

2020 ◽  
Vol 20 ◽  
Author(s):  
Md. Junaid ◽  
Yeasmin Akter ◽  
Syeda Samira Afrose ◽  
Mousumi Tania ◽  
Md. Asaduzzaman Khan
Keyword(s):  
Clinical Trials ◽  
Signaling Pathways ◽  
Signaling Pathway ◽  
Inhibitory Effect ◽  
Akt Signaling ◽  
Review Article ◽  
Therapeutic Drug ◽  
Akt Signaling Pathway ◽  
Anti Cancer

Background: AKT/PKB is an important enzyme with numerous biological functions, and its overexpression is related to the carcinogenesis. AKT stimulates different signaling pathways that are downstream of activated tyrosine kinases and phosphatidylinositol 3-kinase, hence functions as an important target for anti-cancer drugs. Objective: In this review article, we have interpreted the role of AKT signaling pathways in cancer and natural inhibitory effect of Thymoquinone (TQ) in AKT and its possible mechanism. Method: We have collected the updated information and data on AKT, their role in cancer and inhibitory effect of TQ in AKT signaling pathway from google scholar, PubMed, Web of Science, Elsevier, Scopus and many more. Results: There are many drugs already developed, which can target AKT, but very few among them have passed clinical trials. TQ is a natural compound, mainly found in black cumin, which has been found to have potential anti-cancer activities. TQ targets numerous signaling pathways, including AKT, in different cancers. In fact, many studies revealed that AKT is one of the major targets of TQ. The preclinical success of TQ suggests its clinical studies on cancer. Conclusion: This review article summarizes the role of AKT in carcinogenesis, its potent inhibitors in clinical trials, and how TQ acts as an inhibitor of AKT and TQ’s future as a cancer therapeutic drug.

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