scholarly journals Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Serena Vella ◽  
Ilaria Penna ◽  
Luca Longo ◽  
Giulia Pioggia ◽  
Patrizia Garbati ◽  
...  
Keyword(s):  
Antitumor Efficacy ◽  
Over Expression ◽  
Perhexiline Maleate

1442: CXCL12 Over-Expression and Secretion by Aging Fibroblasts Stimulates Human Prostate Epithelial Proliferation in Vitro

2006 ◽  
Vol 175 (4S) ◽  
pp. 466-466
Author(s):  
Jill A. Macoska ◽  
Lesa Begley ◽  
Christine Monteleon ◽  
James W. MacDonald ◽  
Rajal B. Shah
Keyword(s):  
Human Prostate ◽  
Epithelial Proliferation ◽  
Over Expression ◽  
Proliferation In Vitro

Cytotoxicity, NF-κB P65 inhibition, and in vivo antitumor efficacy of sesquiterpene lactones from Piptocoma rufescens

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
Y Ren ◽  
U Muñoz Acuña ◽  
DD Lantvit ◽  
F Jiménez ◽  
R García ◽  
...  
Keyword(s):  
Sesquiterpene Lactones ◽  
Antitumor Efficacy

Perhexiline maleate induced cirrhosis

Pathology ◽  
1983 ◽  
Vol 15 (2) ◽  
pp. 201-203 ◽  
Author(s):  
Arnoldus S. Pieterse ◽  
R. Rowland ◽  
D. Dunn
Keyword(s):  
Perhexiline Maleate

MiR-144-3p Inhibits BMSC Proliferation and Osteogenic Differentiation Via Targeting FZD4 in Steroid-Associated Osteonecrosis

2020 ◽  
Vol 25 (45) ◽  
pp. 4806-4812 ◽  
Author(s):  
Zhibo Sun ◽  
Fei Wu ◽  
Yue Yang ◽  
Feng Liu ◽  
Fengbo Mo ◽  
...  
Keyword(s):  
Real Time ◽  
Real Time Pcr ◽  
Nuclear Translocation ◽  
Bone Diseases ◽  
Luciferase Reporter ◽  
Reporter Assay ◽  
Alizarin Red ◽  
Over Expression ◽  
Negative Effect ◽  
Proliferation Ability

Background: MicroRNAs have recently been recognized to be engaged in the development of bone diseases. Objective: This study was performed to elucidate the effects of miR-144-3p on proliferation and osteogenesis of mesenchymal stem cells (MSCs) from the patients with steroid-associated osteonecrosis (ONFH) and its related mechanism. Method: The expression level of miR-144-3p in the MSCs from the proximal femur of the patients was examined by Real-time PCR. The cell proliferation ability was assayed by MTT. The differentiation ability of MSCs was assayed by Alizarin Red S (ARS) staining. The interaction between miR-144-3p and frizzled4 (FZD4) was investigated by Real-time PCR, western blot and luciferase reporter assay. Results: ONFH samples had the obviously high expression of miR-144-3p compared to the control. MiR-144-3p had a negative effect on the proliferation and osteogenesis of MSCs. Via targeting FZD4, miR-144-3p decreased β-catenin nuclear translocation, the transcription of RUNX2 and COL1A1. Over-expression of FZD4 partially reversed miR-144-3p-induced decrease in the proliferation and osteogenesis of MSCs. Conclusion: MiR-144-3p might play an important role in the development of ONFH and might be used as a novel class of therapeutic targets for this disease.

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