Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Henning Gram Hansen; Claes Nymand Nilsson; Anne Mathilde Lund; Stefan Kol; Lise Marie Grav; Magnus Lundqvist; Johan Rockberg; Gyun Min Lee; Mikael Rørdam Andersen; Helene Faustrup Kildegaard

doi:10.1038/srep18016

Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Scientific Reports ◽

10.1038/srep18016 ◽

2015 ◽

Vol 5 (1) ◽

Cited By ~ 18

Author(s):

Henning Gram Hansen ◽

Claes Nymand Nilsson ◽

Anne Mathilde Lund ◽

Stefan Kol ◽

Lise Marie Grav ◽

...

Keyword(s):

Recombinant Protein ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

Recombinant Protein Productivity ◽

Protein Productivity ◽

Screening Platform

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RNA interference of cofilin in Chinese hamster ovary cells improves recombinant protein productivity

Biotechnology and Bioengineering ◽

10.1002/bit.23322 ◽

2011 ◽

Vol 109 (2) ◽

pp. 528-535 ◽

Cited By ~ 16

Author(s):

Stephanie Hammond ◽

Kelvin H. Lee

Keyword(s):

Rna Interference ◽

Recombinant Protein ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

Recombinant Protein Productivity ◽

Protein Productivity

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Profiling and engineering of microRNAs for enhancing recombinant protein productivity in Chinese hamster ovary cells

BMC Proceedings ◽

10.1186/1753-6561-7-s6-p102 ◽

2013 ◽

Vol 7 (S6) ◽

Author(s):

Wan Ping Loh ◽

Bernard Loo ◽

Lihan Zhou ◽

Peiqing Zhang ◽

Dong Yup Lee ◽

...

Keyword(s):

Recombinant Protein ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

Recombinant Protein Productivity ◽

Protein Productivity

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Constitutively active Rheb mutants [T23M] and [E40K] drive increased production and secretion of recombinant protein in Chinese hamster ovary cells

Biotechnology and Bioengineering ◽

10.1002/bit.27748 ◽

2021 ◽

Author(s):

Stuart P. De Poi ◽

Jianling Xie ◽

C. Mark Smales ◽

Christopher G. Proud

Keyword(s):

Recombinant Protein ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

Constitutively Active

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Transfection of miR-31* boosts oxidative phosphorylation metabolism in the mitochondria and enhances recombinant protein production in Chinese hamster ovary cells

Journal of Biotechnology ◽

10.1016/j.jbiotec.2021.04.012 ◽

2021 ◽

Author(s):

Jesus E. Martinez-Lopez ◽

Orla Coleman ◽

Paula Meleady ◽

Martin Clynes

Keyword(s):

Recombinant Protein ◽

Oxidative Phosphorylation ◽

Chinese Hamster Ovary ◽

Recombinant Protein Production ◽

Protein Production ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells

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Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells

ACS Omega ◽

10.1021/acsomega.0c06030 ◽

2021 ◽

Author(s):

Saumel Pérez-Rodriguez ◽

Tune Wulff ◽

Bjørn G. Voldborg ◽

Claudia Altamirano ◽

Mauricio A. Trujillo-Roldán ◽

...

Keyword(s):

Recombinant Protein ◽

Chinese Hamster Ovary ◽

Recombinant Protein Production ◽

Protein Production ◽

Secretory Pathway ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Proteomic Profiling ◽

Ovary Cells

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Decision letter for "Effective temperature shift strategy development and scale confirmation for simultaneous optimization of protein productivity and quality in Chinese hamster ovary cells"

10.1002/btpr.2959/v1/decision1 ◽

2019 ◽

Keyword(s):

Effective Temperature ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Temperature Shift ◽

Simultaneous Optimization ◽

Strategy Development ◽

Ovary Cells ◽

Shift Strategy ◽

Protein Productivity

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Temperature control of growth and productivity in mutant Chinese hamster ovary cells synthesizing a recombinant protein

Biotechnology and Bioengineering ◽

10.1002/bit.260420903 ◽

1993 ◽

Vol 42 (9) ◽

pp. 1029-1036 ◽

Cited By ~ 30

Author(s):

Nigel Jenkins ◽

Alison Hovey

Keyword(s):

Recombinant Protein ◽

Temperature Control ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells

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Chinese Hamster Ovary Cells, Recombinant Protein Production

Encyclopedia of Industrial Biotechnology ◽

10.1002/9780470054581.eib214 ◽

2010 ◽

Author(s):

David L. Hacker ◽

Sébastien Chenuet ◽

Florian M. Wurm

Keyword(s):

Recombinant Protein ◽

Chinese Hamster Ovary ◽

Recombinant Protein Production ◽

Protein Production ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells

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Chinese Hamster Ovary Cells, Recombinant Protein Production

Encyclopedia of Bioprocess Technology ◽

10.1002/0471250589.ebt047 ◽

2002 ◽

Author(s):

Florian M. Wurm

Keyword(s):

Recombinant Protein ◽

Chinese Hamster Ovary ◽

Recombinant Protein Production ◽

Protein Production ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells

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Effect of shear stress on expression of a recombinant protein by Chinese hamster ovary cells

Biotechnology and Bioengineering ◽

10.1002/bit.10472 ◽

2002 ◽

Vol 81 (2) ◽

pp. 211-220 ◽

Cited By ~ 64

Author(s):

Julian T. Keane ◽

David Ryan ◽

Peter P. Gray

Keyword(s):

Shear Stress ◽

Recombinant Protein ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells

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