scholarly journals Erratum: Dose-dependent protective effect of nicotine in a murine model of viral myocarditis induced by coxsackievirus B3

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Ge Li-Sha ◽  
Zhao Jing-Lin ◽  
Chen Guang-Yi ◽  
Liu Li ◽  
Zhou De-Pu ◽  
...  
Keyword(s):  
Protective Effect ◽  
Murine Model ◽  
Viral Myocarditis ◽  
Coxsackievirus B3 ◽  
Dose Dependent

scholarly journals Dose-dependent protective effect of nicotine in a murine model of viral myocarditis induced by coxsackievirus B3

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Ge Li-Sha ◽  
Zhao Jing-Lin ◽  
Chen Guang-Yi ◽  
Liu Li ◽  
Zhou De-Pu ◽  
...  
Keyword(s):  
Murine Model ◽  
Group Treatment ◽  
Inflammatory Diseases ◽  
Viral Myocarditis ◽  
Coxsackievirus B3 ◽  
Left Ventricular ◽  
Untreated Group ◽  
Myocardial Inflammation ◽  
High Dose ◽  
Dose Dependent

Abstract The alpha 7 nicotinic acetylcholine receptor (alpha7 nAChR) was recently described as an anti-inflammatory target in various inflammatory diseases. The aim of this study was to investigate the dose-related effects of nicotine, an alpha7 nAChR agonist, in murine model of viral myocarditis. BALB/C mice were infected by an intraperitoneally injection with coxsackievirus B3. Nicotine was administered at doses of 0.1, 0.2 or 0.4 mg/kg three times per day for 7 or 14 consecutive days. The effects of nicotine on survival, myocardial histopathological changes, cardiac function and cytokine levels were studied. The survival rate on day 14 increased in a dose-dependent fashion and was markedly higher in the 0.2 and 0.4 mg/kg nicotine groups than in the infected untreated group. Treatment with high-dose nicotine reduced the myocardial inflammation and improved the impaired left ventricular function in infected mice. The mRNA expressions and protein levels of TNF-α, IL-1β, IL-6 and IL-17A were significantly downregulated in dose-dependent manners in the nicotine treatment groups compared to the infected untreated group. Nicotine dose-dependently reduced the severity of viral myocarditis through inhibiting the production of proinflammatory cytokines. The findings suggest that alpha7 nAChR agonists may be a promising new strategy for patients with viral myocarditis.

scholarly journals Comparison of Effects of Ivabradine versus Carvedilol in Murine Model with the Coxsackievirus B3-Induced Viral Myocarditis

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e39394 ◽  
Author(s):  
Li Yue-Chun ◽  
Zhang Teng ◽  
Zhou Na-Dan ◽  
Ge Li-Sha ◽  
Luo Qin ◽  
...  
Keyword(s):  
Murine Model ◽  
Viral Myocarditis ◽  
Coxsackievirus B3

scholarly journals Crocetin Exerts a Cardio-protective Effect on Mice with Coxsackievirus B3-induced Acute Viral Myocarditis

2021 ◽  
Vol 70 (8) ◽  
pp. 1115-1124
Author(s):  
Li Qin ◽  
Hui Liu ◽  
Jinghua Wang ◽  
Wei Wang ◽  
Lei Zhang
Keyword(s):  
Protective Effect ◽  
Viral Myocarditis ◽  
Coxsackievirus B3 ◽  
Acute Viral Myocarditis

scholarly journals Astragaloside IV reduces cardiomyocyte apoptosis in a murine model of coxsackievirus B3-induced viral myocarditis

2019 ◽  
Vol 68 (4) ◽  
pp. 549-558 ◽  
Author(s):  
Tianlong Liu ◽  
Fan Yang ◽  
Jing Liu ◽  
Mingjie Zhang ◽  
Jianjun Sun ◽  
...  
Keyword(s):  
Murine Model ◽  
Viral Myocarditis ◽  
Coxsackievirus B3 ◽  
Cardiomyocyte Apoptosis ◽  
Astragaloside Iv

Protective Effects of Carvedilol in Murine Model With the Coxsackievirus B3-Induced Viral Myocarditis

2008 ◽  
Vol 51 (1) ◽  
pp. 92-98 ◽  
Author(s):  
Li Yue-Chun ◽  
Ge Li-Sha ◽  
Ren Jiang-Hua ◽  
Yang Peng-Lin ◽  
Lin Jia-Feng ◽  
...  
Keyword(s):  
Murine Model ◽  
Viral Myocarditis ◽  
Coxsackievirus B3 ◽  
Protective Effects

Carvedilol has stronger anti-inflammation and anti-virus effects than metoprolol in murine model with coxsackievirus B3-induced viral myocarditis

Gene ◽  
2014 ◽  
Vol 547 (2) ◽  
pp. 195-201 ◽  
Author(s):  
Dan Wang ◽  
Yiming Chen ◽  
Jianbin Jiang ◽  
Aihua Zhou ◽  
Lulu Pan ◽  
...  
Keyword(s):  
Murine Model ◽  
Viral Myocarditis ◽  
Coxsackievirus B3 ◽  
Anti Inflammation

scholarly journals Fasudil exerts a cardio‐protective effect on mice with coxsackievirus B3‐induced acute viral myocarditis

2018 ◽  
Vol 36 (6) ◽  
pp. e12477 ◽  
Author(s):  
Kezhi Dai ◽  
Yaoyao Wang ◽  
Sichao Tai ◽  
Huajing Ni ◽  
Hao Lian ◽  
...  
Keyword(s):  
Protective Effect ◽  
Viral Myocarditis ◽  
Coxsackievirus B3 ◽  
Acute Viral Myocarditis

Expression of Nitric Oxide Synthase in a Murine Model of Viral Myocarditis Induced by Coxsackievirus B3

1996 ◽  
Vol 220 (3) ◽  
pp. 983-989 ◽  
Author(s):  
Shuji Mikami ◽  
Seinosuke Kawashima ◽  
Kenji Kanazawa ◽  
Ken-ichi Hirata ◽  
Yuko Katayama ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Murine Model ◽  
Viral Myocarditis ◽  
Coxsackievirus B3 ◽  
Oxide Synthase
Sign in / Sign up

Export Citation Format

Share Document