scholarly journals ZJU index: a novel model for predicting nonalcoholic fatty liver disease in a Chinese population

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Jinghua Wang ◽  
Chengfu Xu ◽  
Yunhao Xun ◽  
Zhenya Lu ◽  
Junping Shi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Chinese Population ◽  
Nonalcoholic Fatty Liver ◽  
Zju Index ◽  
Novel Model

scholarly journals Development and validation of a nomogram for predicting nonalcoholic fatty liver disease in the non-obese Chinese population

2020 ◽  
Author(s):  
Jiao Wang ◽  
Yunliang Tang ◽  
Kaili Peng ◽  
Honghong Liu ◽  
Jixiong Xu
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Predictive Modeling ◽  
Fatty Liver Disease ◽  
Chinese Population ◽  
Validation Cohort ◽  
Risk Groups ◽  
Training Cohort ◽  
Nonalcoholic Fatty Liver

Abstract Background Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and can be found in non-obese individuals. The purpose of this study was to construct and validate a model for predicting NAFLD in the non-obese Chinese population. Methods A total of 13240 NAFLD-free individuals at baseline from a 4-y longitudinal study were allocated to a training cohort (n = 8872) and a validation cohort (n = 4368). Cox proportional hazards regression analyses were used to select significant variables, and a nomogram was developed to predict NAFLD incidence in the training cohort. Concordance index (C-index), receiver operating characteristic (ROC) curves and calibration curves were applied to assess the predictive modeling of the nomogram in training and validation cohorts. Individuals were categorized into high- or low-risk groups based on median risk scores from the nomogram. Then, a decision curve analysis (DCA) was used to estimate the clinical usefulness of the nomogram in the combined training and validation cohorts. Results The overall incidence of NAFLD was 13%. Nine significant predictors including age, gender, body mass index (BMI), fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), uric acid (UA) and alanine aminotransferase (ALT) were identified and constructed for the nomogram. The C-index was 0.804 [95% CI, 0.792–0.852] and 0.802 [95% CI, 0.784–0.820] in the training and validation cohorts, respectively. In the training cohort, the area under the ROC curve (AUC) for 1-y, 2-y, 3-y and 4-y risk was 0.835, 0.825, 0.816 and 0.782, respectively. Likewise, in the validation cohort, the AUC for 1-y, 2-y, 3-y and 4-y risk was 0.817, 0.820, 0.814 and 0.813. The calibration curves for NAFLD risk showed excellent accuracy in the predictive modeling of the nomogram, internally and externally. The nomogram categorized individuals into high- and low-risk groups, and the DCA displayed the clinical usefulness of the nomogram for predicting NAFLD incidence. Conclusions Our nomogram can predict a personalized risk of NAFLD in the non-obese Chinese population. This nomogram can serve as a simple and affordable tool for stratifying individuals at a high risk of NAFLD, and thus serve to expedite treatment of NAFLD.

scholarly journals Nonalcoholic Fatty Liver Disease Is Associated with Increased Atrial Fibrillation Risk in an Elderly Chinese Population: A Cross-Sectional Study

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Yu Zhang ◽  
Peifei Li ◽  
Min Miao ◽  
Yi Liu ◽  
Yue Pan ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Chinese Population ◽  
Elderly Adults ◽  
Cross Sectional ◽  
Nonalcoholic Fatty Liver ◽  
Elderly Chinese

Background. Atrial fibrillation and nonalcoholic fatty liver disease are two pathological conditions that are highly prevalent worldwide and share multiple CVD risk factors. There are rare researches performed among elderly adults.Aims. We conducted this cross-sectional analysis of elderly adults (≥65 years) to investigate the association between atrial fibrillation and nonalcoholic fatty liver disease.Methods. We analyzed clinical data of the elderly adults (≥ 65 years) who had health examination in Zhenhai Lianhua Hospital, Ningbo, China, in 2014.Results. 522 of the 1688 participants were diagnosed with nonalcoholic fatty liver disease, and 39 participants were diagnosed as having atrial fibrillation. Nonalcoholic fatty liver disease was associated with risk factors for AF in the elderly Chinese population (OR 1.95, 95% CI 1.03-3.69). Adjustments for age, gender, systolic blood pressure, fasting plasma glucose,γ-glutamyl transpeptidase, high-density lipoprotein, triglycerides, total cholesterol and albumin, nonalcoholic fatty liver disease, and prevalent atrial fibrillation remained statistically significant (OR 2.76, 95% CI 1.32-5.77).Conclusions. Our results show that nonalcoholic fatty liver disease is associated with an increased risk of atrial fibrillation in an elderly Chinese population.

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