scholarly journals Dental pulp-derived stem cell conditioned medium reduces cardiac injury following ischemia-reperfusion

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Satoshi Yamaguchi ◽  
Rei Shibata ◽  
Noriyuki Yamamoto ◽  
Masaya Nishikawa ◽  
Hideharu Hibi ◽  
...  
PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0208938 ◽  
Author(s):  
Takeshi Tsuruta ◽  
Kiyoshi Sakai ◽  
Junna Watanabe ◽  
Wataru Katagiri ◽  
Hideharu Hibi

2021 ◽  
pp. 101536
Author(s):  
Giovanna Sarra ◽  
Manoel Eduardo de Lima Machado ◽  
Héctor Valentin Caballero-Flores ◽  
Maria Stella Moreira ◽  
Ana Clara Fagundes Pedroni ◽  
...  

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
HongNa Yang ◽  
Cuilan Wang ◽  
Hui Chen ◽  
Lan Li ◽  
Shuang Ma ◽  
...  

Introduction. Our previous study suggested that NSC-CM (neural stem cell-conditioned medium) inhibited cell apoptosis in vitro. In addition, many studies have shown that neurotrophic factors and microparticles secreted into a conditioned medium by NSCs had neuroprotective effects. Thus, we hypothesized that NSC-CM had the capacity of protecting against cerebral I/R injury. Methods. Adult male Sprague-Dawley rats receiving middle cerebral artery occlusion surgery as an animal model of cerebral I/R injury were randomly assigned to two groups: the control group and NSC-CM-treated group. 1.5 ml NSC-CM or PBS (phosphate buffer saline) was administrated slowly by tail vein at 3 h, 24 h, and 48 h after ischemia onset. Results. NSC-CM significantly ameliorated neurological defects and reduced cerebral infarct volume, accompanied by preserved mitochondrial ultrastructure. In addition, we also found that NSC-CM significantly inhibited cell apoptosis in the ischemic hemisphere via improving the expression of Bcl-2 (B-cell lymphoma-2). Conclusion. NSC-CM might be an alternative and effective therapeutic intervention for ischemic stroke.


Cell Cycle ◽  
2016 ◽  
Vol 15 (8) ◽  
pp. 1144-1155 ◽  
Author(s):  
Qiankun Li ◽  
Yan Chen ◽  
Kui Ma ◽  
Along Zhao ◽  
Cuiping Zhang ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document