scholarly journals In vivo evidence for an endothelium-dependent mechanism in radiation-induced normal tissue injury

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Emilie Rannou ◽  
Agnès François ◽  
Aurore Toullec ◽  
Olivier Guipaud ◽  
Valérie Buard ◽  
...  
Keyword(s):  
Normal Tissue ◽  
Tissue Injury ◽  
Radiation Induced ◽  
Dependent Mechanism

scholarly journals The Radiation-Induced Regenerative Response of Adult Tissue-Specific Stem Cells: Models and Signaling Pathways

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 855
Author(s):  
Paola Serrano Martinez ◽  
Lorena Giuranno ◽  
Marc Vooijs ◽  
Robert P. Coppes
Keyword(s):  
Signaling Pathways ◽  
Progenitor Cells ◽  
Tissue Regeneration ◽  
Normal Tissue ◽  
Cellular Response ◽  
Adult Tissue ◽  
Tissue Specific ◽  
Radiation Induced

Radiotherapy is involved in the treatment of many cancers, but damage induced to the surrounding normal tissue is often inevitable. Evidence suggests that the maintenance of homeostasis and regeneration of the normal tissue is driven by specific adult tissue stem/progenitor cells. These tasks involve the input from several signaling pathways. Irradiation also targets these stem/progenitor cells, triggering a cellular response aimed at achieving tissue regeneration. Here we discuss the currently used in vitro and in vivo models and the involved specific tissue stem/progenitor cell signaling pathways to study the response to irradiation. The combination of the use of complex in vitro models that offer high in vivo resemblance and lineage tracing models, which address organ complexity constitute potential tools for the study of the stem/progenitor cellular response post-irradiation. The Notch, Wnt, Hippo, Hedgehog, and autophagy signaling pathways have been found as crucial for driving stem/progenitor radiation-induced tissue regeneration. We review how these signaling pathways drive the response of solid tissue-specific stem/progenitor cells to radiotherapy and the used models to address this.

Radiation-Induced Normal Tissue Injury

2013 ◽  
pp. 726-727
Author(s):  
Ning J. Yue ◽  
Kent Lambert ◽  
Jay E. Reiff ◽  
Anthony E. Dragun ◽  
Ning J. Yue ◽  
...  
Keyword(s):  
Normal Tissue ◽  
Tissue Injury ◽  
Radiation Induced

Lovastatin attenuates ionizing radiation-induced normal tissue damage in vivo

2009 ◽  
Vol 92 (3) ◽  
pp. 492-499 ◽  
Author(s):  
Christian Ostrau ◽  
Johannes Hülsenbeck ◽  
Melanie Herzog ◽  
Arno Schad ◽  
Michael Torzewski ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Tissue Damage ◽  
Normal Tissue ◽  
Normal Tissue Damage ◽  
Radiation Induced

Imaging Radiation-Induced Normal Tissue Injury to Quantify Regional Dose Response

2017 ◽  
Vol 27 (4) ◽  
pp. 325-331 ◽  
Author(s):  
David V. Fried ◽  
Shiva K. Das ◽  
Lawrence B. Marks
Keyword(s):  
Dose Response ◽  
Normal Tissue ◽  
Tissue Injury ◽  
Radiation Induced
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