scholarly journals Reinforcing endothelial junctions prevents microvessel permeability increase and tumor cell adhesion in microvessels in vivo

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Bingmei M. Fu ◽  
Jinlin Yang ◽  
Bin Cai ◽  
Jie Fan ◽  
Lin Zhang ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Tumor Cell Adhesion ◽  
Endothelial Junctions ◽  
Microvessel Permeability ◽  
Permeability Increase

Interleukin-1 increases tumor cell adhesion to endothelial cells through an RGD dependent mechanism: in vitro and in vivo studies

1990 ◽  
Vol 8 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Davide Lauri ◽  
Maria-Cruz Bertomeu ◽  
F. William Orr ◽  
Eva Bastida ◽  
D. Sauder ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cell Adhesion ◽  
Tumor Cell ◽  
Interleukin 1 ◽  
In Vivo Studies ◽  
Tumor Cell Adhesion ◽  
Dependent Mechanism

scholarly journals Intracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Daniela I. Staquicini ◽  
Roberto Rangel ◽  
Liliana Guzman-Rojas ◽  
Fernanda I. Staquicini ◽  
Andrey S. Dobroff ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Annexin A2 ◽  
Tumor Cell Adhesion ◽  
Intracellular Targeting

Platelet and Shear Rate Promote Tumor Cell Adhesion to Human Endothelial Extracellular Matrix - Absence of a Role for Platelet Cyclooxygenase

1989 ◽  
Vol 61 (03) ◽  
pp. 485-489 ◽  
Author(s):  
Eva Bastida ◽  
Lourdes Almirall ◽  
Antonio Ordinas
Keyword(s):  
Cell Adhesion ◽  
Shear Rate ◽  
Tumor Cell ◽  
Umbilical Vein ◽  
Blood Platelets ◽  
Flow Conditions ◽  
Tumor Cell Adhesion ◽  
Rate Dependent ◽  
Static Conditions

SummaryBlood platelets are thought to be involved in certain aspects of malignant dissemination. To study the role of platelets in tumor cell adherence to vascular endothelium we performed studies under static and flow conditions, measuring tumor cell adhesion in the absence or presence of platelets. We used highly metastatic human adenocarcinoma cells of the lung, cultured human umbilical vein endothelial cells (ECs) and extracellular matrices (ECM) prepared from confluent EC monolayers. Our results indicated that under static conditions platelets do not significantly increase tumor cell adhesion to either intact ECs or to exposed ECM. Conversely, the studies performed under flow conditions using the flat chamber perfusion system indicated that the presence of 2 × 105 pl/μl in the perfusate significantly increased the number of tumor cells adhered to ECM, and that this effect was shear rate dependent. The maximal values of tumor cell adhesion were obtained, in presence of platelets, at a shear rate of 1,300 sec-1. Furthermore, our results with ASA-treated platelets suggest that the role of platelets in enhancing tumor cell adhesion to ECM is independent of the activation of the platelet cyclooxygenase pathway.

scholarly journals Tailored chitosan/hyaluronan coatings for tumor cell adhesion: Effects of topography, charge density and surface composition

2019 ◽  
Vol 486 ◽  
pp. 508-518 ◽  
Author(s):  
J.B.M. Rocha Neto ◽  
T.B. Taketa ◽  
R.A. Bataglioli ◽  
S.B. Pimentel ◽  
D.M. Santos ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Charge Density ◽  
Surface Composition ◽  
Tumor Cell Adhesion
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