scholarly journals Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Stephanie I. Fraley ◽  
Pei-hsun Wu ◽  
Lijuan He ◽  
Yunfeng Feng ◽  
Ranjini Krisnamurthy ◽  
...  
Keyword(s):  
Cell Migration ◽  
Three Dimensional ◽  
Fiber Alignment ◽  
Dimensional Matrix

scholarly journals CdGAP regulates cell migration and adhesion dynamics in two-and three-dimensional matrix environments

Cytoskeleton ◽  
2012 ◽  
Vol 69 (9) ◽  
pp. 644-658 ◽  
Author(s):  
Duncan Wormer ◽  
Nicholas O. Deakin ◽  
Christopher E. Turner
Keyword(s):  
Cell Migration ◽  
Three Dimensional ◽  
Dimensional Matrix

Cell culturing in a three-dimensional matrix affects the localization and properties of plasma membrane cholesterol

2009 ◽  
Vol 33 (10) ◽  
pp. 1079-1086 ◽  
Author(s):  
Nadezhda Stefanova ◽  
Galya Staneva ◽  
Diana Petkova ◽  
Teodora Lupanova ◽  
Roumen Pankov ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Three Dimensional ◽  
Membrane Cholesterol ◽  
Dimensional Matrix ◽  
Cell Culturing ◽  
Plasma Membrane Cholesterol

scholarly journals Computational Model for Cell Migration in Three-Dimensional Matrices

2005 ◽  
Vol 89 (2) ◽  
pp. 1389-1397 ◽  
Author(s):  
Muhammad H. Zaman ◽  
Roger D. Kamm ◽  
Paul Matsudaira ◽  
Douglas A. Lauffenburger
Keyword(s):  
Cell Migration ◽  
Computational Model ◽  
Three Dimensional

scholarly journals Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Masaya Hagiwara ◽  
Hisataka Maruyama ◽  
Masakazu Akiyama ◽  
Isabel Koh ◽  
Fumihito Arai
Keyword(s):  
Cell Migration ◽  
Pattern Formation ◽  
Epithelial Cells ◽  
Optical Tweezers ◽  
Three Dimensional ◽  
Lung Epithelial Cells ◽  
Resistance Force ◽  
Collective Cell Migration ◽  
Physical Forces ◽  
Cellular Movement

AbstractCollective migration of epithelial cells is a fundamental process in multicellular pattern formation. As they expand their territory, cells are exposed to various physical forces generated by cell–cell interactions and the surrounding microenvironment. While the physical stress applied by neighbouring cells has been well studied, little is known about how the niches that surround cells are spatio-temporally remodelled to regulate collective cell migration and pattern formation. Here, we analysed how the spatio-temporally remodelled extracellular matrix (ECM) alters the resistance force exerted on cells so that the cells can expand their territory. Multiple microfabrication techniques, optical tweezers, as well as mathematical models were employed to prove the simultaneous construction and breakage of ECM during cellular movement, and to show that this modification of the surrounding environment can guide cellular movement. Furthermore, by artificially remodelling the microenvironment, we showed that the directionality of collective cell migration, as well as the three-dimensional branch pattern formation of lung epithelial cells, can be controlled. Our results thus confirm that active remodelling of cellular microenvironment modulates the physical forces exerted on cells by the ECM, which contributes to the directionality of collective cell migration and consequently, pattern formation.

On Extremal Positive Maps of Three-Dimensional Matrix Algebra

2021 ◽  
Vol 28 (02) ◽  
Author(s):  
Piotr Ługiewicz ◽  
Robert Olkiewicz
Keyword(s):  
Matrix Algebra ◽  
Three Dimensional ◽  
One Dimensional ◽  
Dimensional Matrix ◽  
Positive Maps

A class of bistochastic maps of three-dimensional matrix algebra which preserves a one-dimensional projector is studied.

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