scholarly journals Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Bo Zheng ◽  
Tandis Vazin ◽  
Patrick W. Goodwill ◽  
Anthony Conway ◽  
Aradhana Verma ◽  
...  
Keyword(s):  
Magnetic Particle ◽  
Neural Cell ◽  
Image Contrast ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

scholarly journals Complex Relationship Between Signal Intensity Properties in Magnetic Particle Imaging (MPI) and Iron Oxide Nanoparticle Degradation

2020 ◽  
Author(s):  
Julia Guzy ◽  
Shatadru Chakravarty ◽  
Foster Buchanan ◽  
Haoran Chen ◽  
Jeffrey M. Gaudet ◽  
...  
Keyword(s):  
Magnetic Particle ◽  
Imaging Modality ◽  
Quantitative Imaging ◽  
Superparamagnetic Nanoparticles ◽  
Iron Oxide Nanoparticle ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

Magnetic particle imaging (MPI) is an exciting new biomedical imaging technology that uses superparamagnetic nanoparticles as an imaging tracer. MPI is touted as a quantitative imaging modality but MPI signal properties have never been characterized for nanoparticles undergoing biodegradation. Here we characterize the nature of the MPI signal properties as a function of degradation of various magnetic particle formulations. We show that MPI signal properties can increase or decrease as a function of nanoparticle formulation and chemical environment and that long-term in vitro experiments only roughly approximate long-term in vivo MPI signal properties. Data are supported by electron microscopy of nanoparticle degradation. Knowledge of MPI signal property changes during nanoparticle degradation will be critical in design and interpretation of all MPI experiments. Further, we demonstrate for the first time, an environmentally sensitive MPI contrast mechanism opening the door to smart contrast paradigms in MPI.<br>

scholarly journals Complex Relationship Between Signal Intensity Properties in Magnetic Particle Imaging (MPI) and Iron Oxide Nanoparticle Degradation

2020 ◽  
Author(s):  
Julia Guzy ◽  
Shatadru Chakravarty ◽  
Foster Buchanan ◽  
Haoran Chen ◽  
Jeffrey M. Gaudet ◽  
...  
Keyword(s):  
Magnetic Particle ◽  
Imaging Modality ◽  
Quantitative Imaging ◽  
Superparamagnetic Nanoparticles ◽  
Iron Oxide Nanoparticle ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

Magnetic particle imaging (MPI) is an exciting new biomedical imaging technology that uses superparamagnetic nanoparticles as an imaging tracer. MPI is touted as a quantitative imaging modality but MPI signal properties have never been characterized for nanoparticles undergoing biodegradation. Here we characterize the nature of the MPI signal properties as a function of degradation of various magnetic particle formulations. We show that MPI signal properties can increase or decrease as a function of nanoparticle formulation and chemical environment and that long-term in vitro experiments only roughly approximate long-term in vivo MPI signal properties. Data are supported by electron microscopy of nanoparticle degradation. Knowledge of MPI signal property changes during nanoparticle degradation will be critical in design and interpretation of all MPI experiments. Further, we demonstrate for the first time, an environmentally sensitive MPI contrast mechanism opening the door to smart contrast paradigms in MPI.<br>

scholarly journals Complex Relationship Between Signal Intensity Properties in Magnetic Particle Imaging (MPI) and Iron Oxide Nanoparticle Degradation

2020 ◽  
Author(s):  
Julia Guzy ◽  
Shatadru Chakravarty ◽  
Foster Buchanan ◽  
Haoran Chen ◽  
Jeffrey M. Gaudet ◽  
...  
Keyword(s):  
Magnetic Particle ◽  
Imaging Modality ◽  
Quantitative Imaging ◽  
Superparamagnetic Nanoparticles ◽  
Iron Oxide Nanoparticle ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

Magnetic particle imaging (MPI) is an exciting new biomedical imaging technology that uses superparamagnetic nanoparticles as an imaging tracer. MPI is touted as a quantitative imaging modality but MPI signal properties have never been characterized for nanoparticles undergoing biodegradation. Here we characterize the nature of the MPI signal properties as a function of degradation of various magnetic particle formulations. We show that MPI signal properties can increase or decrease as a function of nanoparticle formulation and chemical environment and that long-term in vitro experiments only roughly approximate long-term in vivo MPI signal properties. Data are supported by electron microscopy of nanoparticle degradation. Knowledge of MPI signal property changes during nanoparticle degradation will be critical in design and interpretation of all MPI experiments. Further, we demonstrate for the first time, an environmentally sensitive MPI contrast mechanism opening the door to smart contrast paradigms in MPI.<br>

scholarly journals In vivo magnetic particle imaging: angiography of inferior vena cava and aorta in rats using newly developed multicore particles

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Azadeh Mohtashamdolatshahi ◽  
Harald Kratz ◽  
Olaf Kosch ◽  
Ralf Hauptmann ◽  
Nicola Stolzenburg ◽  
...  
Keyword(s):  
Image Quality ◽  
Inferior Vena Cava ◽  
Temporal Resolution ◽  
Magnetic Particle ◽  
Inferior Vena ◽  
Vena Cava ◽  
High Temporal Resolution ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

Abstract Magnetic Particle Imaging (MPI) is a new imaging modality, which maps the distribution of magnetic nanoparticles (MNP) in 3D with high temporal resolution. It thus may be suited for cardiovascular imaging. Its sensitivity and spatial resolution critically depend on the magnetic properties of MNP. Therefore, we used novel multicore nanoparticles (MCP 3) for in-vivo MPI in rats and analyzed dose requirements, sensitivity and detail resolution. 8 rats were examined using a preclinical MPI scanner (Bruker Biospin GmbH, Germany) equipped with a separate receive coil. MCP 3 and Resovist were administered intravenously (i.v.) into the rats’ tail veins at doses of 0.1, 0.05 and 0.025 mmol Fe/kg followed by serial MPI acquisition with a temporal resolution of 46 volumes per second. Based on a qualitative visual scoring system MCP 3–MPI images showed a significantly (P ≤ 0.05) higher image quality than Resovist-MPI images. Morphological features such as vessel lumen diameters (DL) of the inferior vena cava (IVC) and abdominal aorta (AA) could be assessed along a 2-cm segment in mesenteric area only after administration of MCP 3 at dosages of 0.1, 0.05 mmol Fe/kg. The mean DL ± SD estimated was 2.7 ± 0.6 mm for IVC and 2.4 ± 0.7 mm for AA. Evaluation of DL of the IVC and AA was not possible in Resovist-MPI images. Our results show, that MCP 3 provide better image quality at a lower dosage than Resovist. MCP 3-MPI with a clinically acceptable dose of 0.05 mmol Fe/kg increased the visibility of vessel lumens compared to Resovist-based MPI towards possible detection of vascular abnormalities such as stenosis or aneurysms, in vivo.

scholarly journals Tracking short-term biodistribution and long-term clearance of SPIO tracers in magnetic particle imaging

2017 ◽  
Vol 62 (9) ◽  
pp. 3440-3453 ◽  
Author(s):  
Paul Keselman ◽  
Elaine Y Yu ◽  
Xinyi Y Zhou ◽  
Patrick W Goodwill ◽  
Prashant Chandrasekharan ◽  
...  
Keyword(s):  
Magnetic Particle ◽  
Short Term ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

scholarly journals In vivo tracking and quantification of inhaled aerosol using magnetic particle imaging towards inhaled therapeutic monitoring

Theranostics ◽  
2018 ◽  
Vol 8 (13) ◽  
pp. 3676-3687 ◽  
Author(s):  
Zhi Wei Tay ◽  
Prashant Chandrasekharan ◽  
Xinyi Yedda Zhou ◽  
Elaine Yu ◽  
Bo Zheng ◽  
...  
Keyword(s):  
Magnetic Particle ◽  
Therapeutic Monitoring ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

scholarly journals Tracking Adoptive T Cell Therapy Using Magnetic Particle Imaging

2020 ◽  
Author(s):  
Angelie Rivera-Rodriguez ◽  
Lan B. Hoang-Minh ◽  
Andreina Chiu-Lam ◽  
Nicole Sarna ◽  
Leyda Marrero-Morales ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Solid Tumors ◽  
Magnetic Particle ◽  
Ex Vivo ◽  
Intraventricular Administration ◽  
Magnetic Particle Imaging ◽  
Particle Imaging ◽  
The Brain

ABSTRACTAdoptive cellular therapy (ACT) is a potent strategy to boost the immune response against cancer. ACT is an effective treatment for blood cancers, such as leukemias and lymphomas, but faces challenges treating solid tumors and cancers in locations like the brain. A critical step for success of ACT immunotherapy is achieving efficient trafficking of T cells to solid tumors, and the non-invasive and quantitative tracking of adoptively transferred T cell biodistribution would accelerate its development. Here, we demonstrate the use of Magnetic Particle Imaging (MPI) to non-invasively track ACT T cells in vivo. Labeling T cells with the superparamagnetic iron oxide nanoparticle tracer ferucarbotran did not affect T cell viability, phenotype, or cytotoxic function in vitro. Following ACT, ferucarbotran-labeled T cells were detected and quantified using MPI ex vivo and in vivo, in a mouse model of invasive brain cancer. Proof-of-principle in vivo MPI demonstrated its capacity to detect labeled T cells in lungs and liver after intravenous administration and to monitor T cell localization in the brain after intraventricular administration. Ex vivo imaging using MPI and optical imaging suggests accumulation of systemically administered ferucarbotran-labeled T cells in the brain, where MPI signal from ferucarbotran tracers and fluorescently tagged T cells were observed. Ex vivo imaging also suggest differential accumulation of nanoparticles and viable T cells in other organs like the spleen and liver. These results support the use of MPI to track adoptively transferred T cells and accelerate the development of ACT treatments for brain tumors and other cancers.

scholarly journals Abstract 2770: Imaging cancer immunology: Monitoring CD47 mAb treatment in vivo by magnetic particle imaging

2020 ◽  
Author(s):  
Gang Ren ◽  
Jeff M. Gaudet ◽  
Marco Gerosa ◽  
Yanrong Zhang ◽  
James Mansfield ◽  
...  
Keyword(s):  
Magnetic Particle ◽  
Cancer Immunology ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

scholarly journals Magnetic Particle Imaging-Guided Heating in Vivo Using Gradient Fields for Arbitrary Localization of Magnetic Hyperthermia Therapy

ACS Nano ◽  
2018 ◽  
Vol 12 (4) ◽  
pp. 3699-3713 ◽  
Author(s):  
Zhi Wei Tay ◽  
Prashant Chandrasekharan ◽  
Andreina Chiu-Lam ◽  
Daniel W. Hensley ◽  
Rohan Dhavalikar ◽  
...  
Keyword(s):  
Magnetic Particle ◽  
Magnetic Hyperthermia ◽  
Magnetic Particle Imaging ◽  
Hyperthermia Therapy ◽  
Gradient Fields ◽  
Particle Imaging
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