scholarly journals Age at menarche and endometrial cancer risk: a dose-response meta-analysis of prospective studies

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Ting-Ting Gong ◽  
Yong-Lai Wang ◽  
Xiao-Xin Ma
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Dose Response ◽  
Prospective Studies ◽  
Meta Analysis ◽  
Age At Menarche ◽  
Endometrial Cancer Risk

scholarly journals Anthropometric factors and endometrial cancer risk: a systematic review and dose–response meta-analysis of prospective studies

2015 ◽  
Vol 26 (8) ◽  
pp. 1635-1648 ◽  
Author(s):  
D. Aune ◽  
D.A. Navarro Rosenblatt ◽  
D.S.M. Chan ◽  
S. Vingeliene ◽  
L. Abar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Dose Response ◽  
Prospective Studies ◽  
Meta Analysis ◽  
Endometrial Cancer Risk

Overweight, Obesity and Endometrial Cancer Risk: Results from a Systematic Review and Meta-Analysis

2014 ◽  
Vol 29 (1) ◽  
pp. e21-e29 ◽  
Author(s):  
Yuanyuan Zhang ◽  
Huaizhen Liu ◽  
Shengjie Yang ◽  
Jinjun Zhang ◽  
Liwei Qian ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Body Mass ◽  
Meta Analysis ◽  
Overweight And Obesity ◽  
Age At Menarche ◽  
Published Data ◽  
Endometrial Cancer Risk ◽  
Increased Risk

Aim Findings from recent studies suggest that obesity may be associated with an increased risk of endometrial cancer, but several earlier studies were less conclusive. Here we strive to estimate this relationship in a meta-analysis of published data. Methods We searched Pubmed and Embase for studies on body mass index and the risk of endometrial cancer, published from 1989 to 2011. Data were independently extracted and analyzed using random or fixed effects meta-analysis depending on the degree of heterogeneity. Results Seven cohort studies and 11 case-control studies were included in the meta-analysis. Overall, the conditions of excess body weight ([EBW] defined as body mass index [BMI] ≥25 kg/m2), obesity (BMI ≥30 kg/m2) and overweight (25< BMI <30 kg/m2) were associated with an increased risk of endometrial cancer (relative risk [RR] for EBW=1.62, 95% confidence interval [CI], 1.39-1.89; for obesity RR=2.54, 95% CI, 2.11-3.06; for overweight RR=1.32, 95% CI, 1.16-1.50). Subgroup analyses showed that the positive associations were independent of study design, geographic locations, self-reported BMI, alcohol use, smoking habit, history of diabetes, hormone therapy, age at menarche, age at menopause, parity, and age at first full term pregnancy. However, there was no statistically significant association between EBW and endometrial cancer risk for measured BMI (for EBW RR=1.29, 95% CI, 0.66-2.53). Conclusions The findings from this meta-analysis strongly support that the conditions of EBW, overweight, and obesity are all associated with an increased risk of endometrial cancer. Also, the strength of the association increases with increasing BMI.

scholarly journals Tea Drinking and Risk of Cancer Incidence: A Meta-Analysis of Prospective Cohort Studies and Evidence Evaluation

2020 ◽  
Author(s):  
Long-Gang Zhao ◽  
Zhuo-Ying Li ◽  
Guo-Shan Feng ◽  
Xiao-Wei Ji ◽  
Yu-Ting Tan ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Green Tea ◽  
Dose Response ◽  
Prospective Studies ◽  
Prediction Interval ◽  
Meta Analysis ◽  
Black Tea ◽  
Current Evidence ◽  
Tea Drinking ◽  
Risk Of Cancer

ABSTRACT Here we provide a comprehensive meta-analysis to summarize and appraise the quality of the current evidence on the associations of tea drinking in relation to cancer risk. PubMed, Embase, and the Cochrane Database of Systematic Reviews were searched up to June 2020. We reanalyzed the individual prospective studies focused on associations between tea drinking and cancer risk in humans. We conducted a meta-analysis of prospective studies and provided the highest- versus lowest-category analyses, dose-response analyses, and test of nonlinearity of each association by modeling restricted cubic spline regression for each type of tea. We graded the evidence based on the summary effect size, its 95% confidence interval, 95% prediction interval, the extent of heterogeneity, evidence of small-study effects, and excess significance bias. We identified 113 individual studies investigating the associations between tea drinking and 26 cancer sites including 153,598 cancer cases. We assessed 12 associations for the intake of black tea with cancer risk and 26 associations each for the intake of green tea and total tea with cancer risk. Except for an association between lymphoid neoplasms with green tea, we did not find consistent associations for the highest versus lowest categories and dose-response analyses for any cancer. When grading current evidence for each association (number of studies ≥2), weak evidence was detected for lymphoid neoplasm (green tea), glioma (total tea, per 1 cup), bladder cancer (total tea, per 1 cup), and gastric and esophageal cancer (tea, per 1 cup). This review of prospective studies provides little evidence to support the hypothesis that tea drinking is associated with cancer risk. More well-designed studies are still needed to identify associations between tea intake and rare cancers.

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