scholarly journals Prognostic value of parotid lymph node metastasis in patients with nasopharyngeal carcinoma receiving intensity-modulated radiotherapy

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Yuan Zhang ◽  
Wen-Fei Li ◽  
Lei Chen ◽  
Yan-Ping Mao ◽  
Rui Guo ◽  
...  
Keyword(s):  
Lymph Node ◽  
Nasopharyngeal Carcinoma ◽  
Lymph Node Metastasis ◽  
Prognostic Value ◽  
Intensity Modulated Radiotherapy ◽  
Node Metastasis ◽  
Intensity Modulated

scholarly journals Retropharyngeal Lymph Node Metastasis in Nasopharyngeal Carcinoma: Prognostic Value and Staging Categories

2007 ◽  
Vol 13 (5) ◽  
pp. 1445-1452 ◽  
Author(s):  
Jun Ma ◽  
Lizhi Liu ◽  
Linglong Tang ◽  
Jingfeng Zong ◽  
Aihua Lin ◽  
...  
Keyword(s):  
Lymph Node ◽  
Nasopharyngeal Carcinoma ◽  
Lymph Node Metastasis ◽  
Prognostic Value ◽  
Retropharyngeal Lymph Node ◽  
Node Metastasis

scholarly journals Prognostic Value of CD10 among Tunisian Patients with Nasopharyngeal Carcinoma

2021 ◽  
Vol 8 (11) ◽  
Author(s):  
Mokni Baizig N ◽  
◽  
Mhamdi H ◽  
El Amine El Hadj O ◽  
Goucha A ◽  
...  
Keyword(s):  
Lymph Node ◽  
Nasopharyngeal Carcinoma ◽  
Lymph Node Metastasis ◽  
Prognostic Value ◽  
Strong Association ◽  
Normal Mucosa ◽  
Control Group ◽  
Node Metastasis ◽  
Cd10 Expression ◽  
Cox Proportional Hazard Regression

Introduction: CD10 expression was identified as a marker of poor prognosis in several types of cancer. However, its impact on the survival of Tunisian NPC patients has not been discussed. So, our objective was to confirm the prognostic value of this marker, in addition to its relationship to clinicopathologic parameters. Materials and Methods: Imunohistochemistry method was performed on formalin-fixed paraffin-embedded sections of 66 cases of NPC, 6 patients with inflammatory nasopharynx and 20 normal mucosa tissues. Results: CD10 expression was detected in 66.66 % of the NPC with predominant staining in stromal cells (81.81%). While, no expression of CD10 was noted in control group (inflammatory nasopharyngeal lesions and normal nasopharynx mucosa). CD10 positive cases were correlated with increasing tumor size (p=0.001) and lymph node metastasis (p=0.034). Furthermore, with the Kaplan-Meier test, a strong association was observed between the expression of CD10 and the recurrence status (p = 0.003). Multivariate Cox proportional hazard regression analysis showed that CD10 and lymph node metastasis factors were independent predictors of time to recurrence among NPC patients with respectively p=0.001 and p=0.044. Conclusion: The present study confirms the prognostic value of CD10 expression and suggests its strong effect on aggressive behavior of nasopharyngeal carcinoma.

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