scholarly journals Carbon ions induce autophagy effectively through stimulating the unfolded protein response and subsequent inhibiting Akt phosphorylation in tumor cells

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Xiaodong Jin ◽  
Feifei Li ◽  
Xiaogang Zheng ◽  
Yan Liu ◽  
Ryoichi Hirayama ◽  
...  
Keyword(s):  
Unfolded Protein Response ◽  
Tumor Cells ◽  
Carbon Ions ◽  
Akt Phosphorylation ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

Abstract 2081: The unfolded protein response relieves stress in tumor cells by stimulating angiogenesis

2011 ◽  
Author(s):  
Yugang Wang ◽  
Yu Ning ◽  
Goleeta Alam ◽  
Fernanda Visioli ◽  
Jacques E. Nör ◽  
...  
Keyword(s):  
Unfolded Protein Response ◽  
Tumor Cells ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response

Oncogene ◽  
2021 ◽  
Author(s):  
Evangelos Prokakis ◽  
Anna Dyas ◽  
Regina Grün ◽  
Sonja Fritzsche ◽  
Upasana Bedi ◽  
...  
Keyword(s):  
Unfolded Protein Response ◽  
Tumor Cells ◽  
Extended Period ◽  
Unfolded Protein ◽  
Promote Cell Survival ◽  
Specific Protease ◽  
Underlying Mechanisms ◽  
The Unfolded Protein Response ◽  
Protein Response

AbstractThe Ubiquitin-Specific Protease 22 (USP22) is a deubiquitinating subunit of the mammalian SAGA transcriptional co-activating complex. USP22 was identified as a member of the so-called “death-from-cancer” signature predicting therapy failure in cancer patients. However, the importance and functional role of USP22 in different types and subtypes of cancer remain largely unknown. In the present study, we leveraged human cell lines and genetic mouse models to investigate the role of USP22 in HER2-driven breast cancer (HER2+-BC) and demonstrate for the first time that USP22 is required for the tumorigenic properties in murine and human HER2+-BC models. To get insight into the underlying mechanisms, we performed transcriptome-wide gene expression analyses and identified the Unfolded Protein Response (UPR) as a pathway deregulated upon USP22 loss. The UPR is normally induced upon extrinsic or intrinsic stresses that can promote cell survival and recovery if shortly activated or programmed cell death if activated for an extended period. Strikingly, we found that USP22 actively suppresses UPR induction in HER2+-BC cells by stabilizing the major endoplasmic reticulum (ER) chaperone HSPA5. Consistently, loss of USP22 renders tumor cells more sensitive to apoptosis and significantly increases the efficiency of therapies targeting the ER folding capacity. Together, our data suggest that therapeutic strategies targeting USP22 activity may sensitize tumor cells to UPR induction and could provide a novel, effective approach to treat HER2+-BC.

scholarly journals The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway

2012 ◽  
Vol 72 (20) ◽  
pp. 5396-5406 ◽  
Author(s):  
Yugang Wang ◽  
Goleeta N. Alam ◽  
Yu Ning ◽  
Fernanda Visioli ◽  
Zhihong Dong ◽  
...  
Keyword(s):  
Unfolded Protein Response ◽  
Tumor Cells ◽  
Human Tumor ◽  
Human Tumor Cells ◽  
Angiogenic Switch ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

2010 ◽  
Vol 120 (1) ◽  
pp. 127-141 ◽  
Author(s):  
Kasper M.A. Rouschop ◽  
Twan van den Beucken ◽  
Ludwig Dubois ◽  
Hanneke Niessen ◽  
Johan Bussink ◽  
...  
Keyword(s):  
Unfolded Protein Response ◽  
Tumor Cells ◽  
Human Tumor ◽  
Human Tumor Cells ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals Disulfide bond disrupting agents activate the unfolded protein response in EGFR- and HER2-positive breast tumor cells

Oncotarget ◽  
2017 ◽  
Vol 8 (17) ◽  
pp. 28971-28989 ◽  
Author(s):  
Renan B. Ferreira ◽  
Mengxiong Wang ◽  
Mary E. Law ◽  
Bradley J. Davis ◽  
Ashton N. Bartley ◽  
...  
Keyword(s):  
Unfolded Protein Response ◽  
Tumor Cells ◽  
Disulfide Bond ◽  
Breast Tumor ◽  
Her2 Positive ◽  
Breast Tumor Cells ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals Role of the unfolded protein response in determining the fate of tumor cells and the promise of multi-targeted therapies

2017 ◽  
Vol 23 (3) ◽  
pp. 317-334 ◽  
Author(s):  
Kunyu Shen ◽  
David W. Johnson ◽  
David A. Vesey ◽  
Michael A. McGuckin ◽  
Glenda C. Gobe
Keyword(s):  
Unfolded Protein Response ◽  
Tumor Cells ◽  
Targeted Therapies ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response
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