scholarly journals Memory reconsolidation may be disrupted by a distractor stimulus presented during reactivation

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Ana Paula Crestani ◽  
Flávia Zacouteguy Boos ◽  
Josué Haubrich ◽  
Rodrigo Ordoñez Sierra ◽  
Fabiana Santana ◽  
...  
Keyword(s):  
Memory Reconsolidation ◽  
Distractor Stimulus

scholarly journals Neural substrates of propranolol-induced impairments in the reconsolidation of nicotine-associated memories in smokers

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiao Lin ◽  
Jiahui Deng ◽  
Kai Yuan ◽  
Qiandong Wang ◽  
Lin Liu ◽  
...  
Keyword(s):  
Neural Activity ◽  
Neural Substrates ◽  
Brain Regions ◽  
Reward Processing ◽  
Memory Reconsolidation ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Postcentral Gyrus ◽  
Propranolol Group ◽  
Propranolol Administration

AbstractThe majority of smokers relapse even after successfully quitting because of the craving to smoking after unexpectedly re-exposed to smoking-related cues. This conditioned craving is mediated by reward memories that are frequently experienced and stubbornly resistant to treatment. Reconsolidation theory posits that well-consolidated memories are destabilized after retrieval, and this process renders memories labile and vulnerable to amnestic intervention. This study tests the retrieval reconsolidation procedure to decrease nicotine craving among people who smoke. In this study, 52 male smokers received a single dose of propranolol (n = 27) or placebo (n = 25) before the reactivation of nicotine-associated memories to impair the reconsolidation process. Craving for smoking and neural activity in response to smoking-related cues served as primary outcomes. Functional magnetic resonance imaging was performed during the memory reconsolidation process. The disruption of reconsolidation by propranolol decreased craving for smoking. Reactivity of the postcentral gyrus in response to smoking-related cues also decreased in the propranolol group after the reconsolidation manipulation. Functional connectivity between the hippocampus and striatum was higher during memory reconsolidation in the propranolol group. Furthermore, the increase in coupling between the hippocampus and striatum positively correlated with the decrease in craving after the reconsolidation manipulation in the propranolol group. Propranolol administration before memory reactivation disrupted the reconsolidation of smoking-related memories in smokers by mediating brain regions that are involved in memory and reward processing. These findings demonstrate the noradrenergic regulation of memory reconsolidation in humans and suggest that adjunct propranolol administration can facilitate the treatment of nicotine dependence. The present study was pre-registered at ClinicalTrials.gov (registration no. ChiCTR1900024412).

Intervention strength does not differentially affect memory reconsolidation of strong memories

2017 ◽  
Vol 144 ◽  
pp. 174-185 ◽  
Author(s):  
Kevin van Schie ◽  
Suzanne C. van Veen ◽  
Yanniek R. Hendriks ◽  
Marcel A. van den Hout ◽  
Iris M. Engelhard
Keyword(s):  
Memory Reconsolidation

scholarly journals BDNF controls object recognition memory reconsolidation

2017 ◽  
Vol 142 ◽  
pp. 79-84 ◽  
Author(s):  
Andressa Radiske ◽  
Janine I. Rossato ◽  
Maria Carolina Gonzalez ◽  
Cristiano A. Köhler ◽  
Lia R. Bevilaqua ◽  
...  
Keyword(s):  
Object Recognition ◽  
Recognition Memory ◽  
Memory Reconsolidation ◽  
Object Recognition Memory

scholarly journals Enhancing cognition by affecting memory reconsolidation

2015 ◽  
Vol 4 ◽  
pp. 41-47 ◽  
Author(s):  
Emiliano Merlo ◽  
Amy L Milton ◽  
Barry J Everitt
Keyword(s):  
Memory Reconsolidation
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