scholarly journals OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Huarong Chen ◽  
Renduo Song ◽  
Guohui Wang ◽  
Zonghui Ding ◽  
Chunying Yang ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Stress Response ◽  
Complex Formation ◽  
Ternary Complex ◽  
Integrated Stress Response ◽  
Ternary Complex Formation

scholarly journals The acute transcriptional responses to dietary methionine restriction are triggered by inhibition of ternary complex formation and linked to Erk1/2, mTOR, and ATF4

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kirsten P. Stone ◽  
Sujoy Ghosh ◽  
Jean Paul Kovalik ◽  
Manda Orgeron ◽  
Desiree Wanders ◽  
...  
Keyword(s):  
Stress Response ◽  
Complex Formation ◽  
Ternary Complex ◽  
Target Genes ◽  
Bioinformatic Analysis ◽  
Transcriptional Responses ◽  
Metabolomics Data ◽  
Ternary Complex Formation ◽  
Methionine Restriction

AbstractThe initial sensing of dietary methionine restriction (MR) occurs in the liver where it activates an integrated stress response (ISR) that quickly reduces methionine utilization. The ISR program is regulated in part by ATF4, but ATF4’s prototypical upstream regulator, eIF2α, is not acutely activated by MR. Bioinformatic analysis of RNAseq and metabolomics data from liver samples harvested 3 h and 6 h after initiating MR shows that general translation is inhibited at the level of ternary complex formation by an acute 50% reduction of hepatic methionine that limits formation of initiator methionine tRNA. The resulting ISR is induced by selective expression of ATF4 target genes that mediate adaptation to reduced methionine intake and return hepatic methionine to control levels within 4 days of starting the diet. Complementary in vitro experiments in HepG2 cells after knockdown of ATF4, or inhibition of mTOR or Erk1/2 support the conclusion that the early induction of genes by MR is partially dependent on ATF4 and regulated by both mTOR and Erk1/2. Taken together, these data show that initiation of dietary MR induces an mTOR- and Erk1/2-dependent stress response that is linked to ATF4 by the sharp, initial drop in hepatic methionine and resulting repression of translation pre-initiation.

Ternary complex formation of the nickel(II), 2,2’-bipyridine, 1,10’-Phenanthroline and some aminoacids

2021 ◽  
pp. 1-11
Author(s):  
Yoselin Jara ◽  
Mary Lorena Araujo ◽  
Waleska Madden ◽  
Vito Lubes ◽  
Lino Hernández
Keyword(s):  
Complex Formation ◽  
Ternary Complex ◽  
Ternary Complex Formation

VPS37 Isoforms Differentially Modulate the Ternary Complex Formation of ALIX, ALG-2, and ESCRT-I

2013 ◽  
Vol 77 (8) ◽  
pp. 1715-1721 ◽  
Author(s):  
Mayumi OKUMURA ◽  
Angela M. KATSUYAMA ◽  
Hideki SHIBATA ◽  
Masatoshi MAKI
Keyword(s):  
Complex Formation ◽  
Ternary Complex ◽  
Ternary Complex Formation

scholarly journals Inhibition of Ets-1 DNA Binding and Ternary Complex Formation between Ets-1, NF-κB, and DNA by a Designed DNA-binding Ligand

1999 ◽  
Vol 274 (18) ◽  
pp. 12765-12773 ◽  
Author(s):  
Liliane A. Dickinson ◽  
John W. Trauger ◽  
Eldon E. Baird ◽  
Peter B. Dervan ◽  
Barbara J. Graves ◽  
...  
Keyword(s):  
Dna Binding ◽  
Complex Formation ◽  
Ternary Complex ◽  
Ternary Complex Formation
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