scholarly journals Fluoxetine increases plasticity and modulates the proteomic profile in the adult mouse visual cortex

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
L. Ruiz-Perera ◽  
M. Muniz ◽  
G. Vierci ◽  
N. Bornia ◽  
L. Baroncelli ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Adult Mouse ◽  
Proteomic Profile ◽  
Mouse Visual Cortex

scholarly journals Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Thomas Knöpfel ◽  
Yann Sweeney ◽  
Carola I. Radulescu ◽  
Nawal Zabouri ◽  
Nazanin Doostdar ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Visual Experience ◽  
Adult Mouse ◽  
Neural Circuits ◽  
Multisensory Processing ◽  
Functional Networks ◽  
Auditory Responses ◽  
Visual Events ◽  
Calcium Indicators ◽  
Mouse Visual Cortex

AbstractWe experience the world through multiple senses simultaneously. To better understand mechanisms of multisensory processing we ask whether inputs from two senses (auditory and visual) can interact and drive plasticity in neural-circuits of the primary visual cortex (V1). Using genetically-encoded voltage and calcium indicators, we find coincident audio-visual experience modifies both the supra and subthreshold response properties of neurons in L2/3 of mouse V1. Specifically, we find that after audio-visual pairing, a subset of multimodal neurons develops enhanced auditory responses to the paired auditory stimulus. This cross-modal plasticity persists over days and is reflected in the strengthening of small functional networks of L2/3 neurons. We find V1 processes coincident auditory and visual events by strengthening functional associations between feature specific assemblies of multimodal neurons during bouts of sensory driven co-activity, leaving a trace of multisensory experience in the cortical network.

scholarly journals Arc restores juvenile plasticity in adult mouse visual cortex

2017 ◽  
Author(s):  
Kyle R. Jenks ◽  
Taekeun Kim ◽  
Elissa D. Pastuzyn ◽  
Hiroyuki Okuno ◽  
Andrew V. Taibi ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Neural Plasticity ◽  
Critical Period ◽  
Adult Mouse ◽  
Monocular Deprivation ◽  
Protein Synthesis Inhibitor ◽  
Adult Mice ◽  
Mouse Visual Cortex ◽  
Activity Dependent

AbstractThe molecular basis for the decline in experience-dependent neural plasticity over age remains poorly understood. In visual cortex, the robust plasticity induced in juvenile mice by brief monocular deprivation (MD) during the critical period is abrogated by genetic deletion of Arc, an activity-dependent regulator of excitatory synaptic modification. Here we report that augmenting Arc expression in adult mice prolongs juvenile-like plasticity in visual cortex, as assessed by recordings of ocular dominance (OD) plasticity in vivo. A distinguishing characteristic of juvenile OD plasticity is the weakening of deprived-eye responses, believed to be accounted for by the mechanisms of homosynaptic long-term depression (LTD). Accordingly, we also found increased LTD in visual cortex of adult mice with augmented Arc expression, and impaired LTD in visual cortex of juvenile mice that lack Arc or have been treated in vivo with a protein synthesis inhibitor. Further, we found that although activity-dependent expression of Arc mRNA does not change with age, expression of Arc protein is maximal during the critical period and declines in adulthood. Finally, we show that acute augmentation of Arc expression in wild type adult mouse visual cortex is sufficient to restore juvenile-like plasticity. Together, our findings suggest a unifying molecular explanation for the age- and activity-dependent modulation of synaptic sensitivity to deprivation.Significance StatementNeuronal plasticity peaks early in life during critical periods and normally declines with age, but the molecular changes that underlie this decline are not fully understood. Using the mouse visual cortex as a model, we found that activity-dependent expression of the neuronal protein Arc peaks early in life, and that loss of activity-dependent Arc expression parallels loss of synaptic plasticity in the visual cortex. Genetic overexpression of Arc prolongs the critical period of visual cortex plasticity and acute viral expression of Arc in adult mice can restore juvenile-like plasticity. These findings provide a mechanism for the loss of excitatory plasticity with age, and suggest that Arc may be an exciting therapeutic target for modulation of the malleability of neuronal circuits.

scholarly journals Activation of Somatostatin Interneurons by Nicotinic Modulator Lypd6 Enhances Plasticity and Functional Recovery in the Adult Mouse Visual Cortex

2020 ◽  
Vol 40 (27) ◽  
pp. 5214-5227 ◽  
Author(s):  
Masato Sadahiro ◽  
Michael P. Demars ◽  
Poromendro Burman ◽  
Priscilla Yevoo ◽  
Andreas Zimmer ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Functional Recovery ◽  
Adult Mouse ◽  
Mouse Visual Cortex

scholarly journals Competition and Homeostasis of Excitatory and Inhibitory Connectivity in the Adult Mouse Visual Cortex

2014 ◽  
Vol 25 (10) ◽  
pp. 3713-3722 ◽  
Author(s):  
M. Hadi Saiepour ◽  
Sridhara Chakravarthy ◽  
Rogier Min ◽  
Christiaan N. Levelt
Keyword(s):  
Visual Cortex ◽  
Adult Mouse ◽  
Mouse Visual Cortex

scholarly journals Loss of Sensory Input Causes Rapid Structural Changes of Inhibitory Neurons in Adult Mouse Visual Cortex

Neuron ◽  
2011 ◽  
Vol 71 (5) ◽  
pp. 869-882 ◽  
Author(s):  
Tara Keck ◽  
Volker Scheuss ◽  
R. Irene Jacobsen ◽  
Corette J. Wierenga ◽  
Ulf T. Eysel ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Sensory Input ◽  
Structural Changes ◽  
Adult Mouse ◽  
Inhibitory Neurons ◽  
Mouse Visual Cortex

scholarly journals Arc restores juvenile plasticity in adult mouse visual cortex

2017 ◽  
Vol 114 (34) ◽  
pp. 9182-9187 ◽  
Author(s):  
Kyle R. Jenks ◽  
Taekeun Kim ◽  
Elissa D. Pastuzyn ◽  
Hiroyuki Okuno ◽  
Andrew V. Taibi ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Neural Plasticity ◽  
Critical Period ◽  
Adult Mouse ◽  
Monocular Deprivation ◽  
Protein Synthesis Inhibitor ◽  
Adult Mice ◽  
Mouse Visual Cortex ◽  
Activity Dependent

The molecular basis for the decline in experience-dependent neural plasticity over age remains poorly understood. In visual cortex, the robust plasticity induced in juvenile mice by brief monocular deprivation during the critical period is abrogated by genetic deletion of Arc, an activity-dependent regulator of excitatory synaptic modification. Here, we report that augmenting Arc expression in adult mice prolongs juvenile-like plasticity in visual cortex, as assessed by recordings of ocular dominance (OD) plasticity in vivo. A distinguishing characteristic of juvenile OD plasticity is the weakening of deprived-eye responses, believed to be accounted for by the mechanisms of homosynaptic long-term depression (LTD). Accordingly, we also found increased LTD in visual cortex of adult mice with augmented Arc expression and impaired LTD in visual cortex of juvenile mice that lack Arc or have been treated in vivo with a protein synthesis inhibitor. Further, we found that although activity-dependent expression of Arc mRNA does not change with age, expression of Arc protein is maximal during the critical period and declines in adulthood. Finally, we show that acute augmentation of Arc expression in wild-type adult mouse visual cortex is sufficient to restore juvenile-like plasticity. Together, our findings suggest a unifying molecular explanation for the age- and activity-dependent modulation of synaptic sensitivity to deprivation.

scholarly journals Evidence for Cross-Modal Plasticity in Adult Mouse Visual Cortex Following Monocular Enucleation

2011 ◽  
Vol 21 (9) ◽  
pp. 2133-2146 ◽  
Author(s):  
L. Van Brussel ◽  
A. Gerits ◽  
L. Arckens
Keyword(s):  
Visual Cortex ◽  
Adult Mouse ◽  
Monocular Enucleation ◽  
Mouse Visual Cortex

scholarly journals Plasticity in Adult Mouse Visual Cortex Following Optic Nerve Injury

2019 ◽  
Vol 29 (4) ◽  
pp. 1767-1777 ◽  
Author(s):  
Asta Vasalauskaite ◽  
James E Morgan ◽  
Frank Sengpiel
Keyword(s):  
Visual Cortex ◽  
Optic Nerve ◽  
Nerve Injury ◽  
Adult Mouse ◽  
Optic Nerve Injury ◽  
Mouse Visual Cortex
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