scholarly journals Erratum: Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR)

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Sandra Gomez ◽  
Laura Adalid-Peralta ◽  
Hector Palafox-Fonseca ◽  
Vito Adrian Cantu-Robles ◽  
Xavier Soberón ◽  
...  
Keyword(s):  
Genome Analysis ◽  
Taenia Solium ◽  
Secretory Proteins ◽  
Antigenic Regions

scholarly journals Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR)

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Sandra Gomez ◽  
Laura Adalid-Peralta ◽  
Hector Palafox-Fonseca ◽  
Vito Adrian Cantu-Robles ◽  
Xavier Soberón ◽  
...  
Keyword(s):  
Taenia Solium ◽  
Experimental Studies ◽  
Cost Effective ◽  
Sequence Length ◽  
Secretory Proteins ◽  
Parasitic Diseases ◽  
Host Parasite Interactions ◽  
Antigenic Proteins ◽  
Host Parasite ◽  
Antigenic Regions

Abstract Excretory/Secretory (ES) proteins play an important role in the host-parasite interactions. Experimental identification of ES proteins is time-consuming and expensive. Alternative bioinformatics approaches are cost-effective and can be used to prioritize the experimental analysis of therapeutic targets for parasitic diseases. Here we predicted and functionally annotated the ES proteins in T. solium genome using an integration of bioinformatics tools. Additionally, we developed a novel measurement to evaluate the potential antigenicity of T. solium secretome using sequence length and number of antigenic regions of ES proteins. This measurement was formalized as the Abundance of Antigenic Regions (AAR) value. AAR value for secretome showed a similar value to that obtained for a set of experimentally determined antigenic proteins and was different to the calculated value for the non-ES proteins of T. solium genome. Furthermore, we calculated the AAR values for known helminth secretomes and they were similar to that obtained for T. solium. The results reveal the utility of AAR value as a novel genomic measurement to evaluate the potential antigenicity of secretomes. This comprehensive analysis of T. solium secretome provides functional information for future experimental studies, including the identification of novel ES proteins of therapeutic, diagnosis and immunological interest.

scholarly journals Identification and Characterization of Microsatellite Markers Derived from the Whole Genome Analysis of Taenia solium

2015 ◽  
Vol 9 (12) ◽  
pp. e0004316 ◽  
Author(s):  
Mónica J. Pajuelo ◽  
María Eguiluz ◽  
Eric Dahlstrom ◽  
David Requena ◽  
Frank Guzmán ◽  
...  
Keyword(s):  
Microsatellite Markers ◽  
Genome Analysis ◽  
Taenia Solium ◽  
Whole Genome ◽  
Whole Genome Analysis ◽  
Identification And Characterization

Ultrastructural Aspects of Golgi Complex Function in Parathyroid Cells of Winter Frogs

1973 ◽  
Vol 31 ◽  
pp. 680-681
Author(s):  
William J. Dougherty
Keyword(s):  
Golgi Complex ◽  
Secretory Granules ◽  
Complex Function ◽  
Secretory Activity ◽  
Secretory Proteins ◽  
Perivascular Spaces ◽  
Pituitary Cells ◽  
Electron Microscopic ◽  
Ca Ions ◽  
Regulation Of Secretion

The regulation of secretion in exocrine and endocrine cells has long been of interest. Electron microscopic and other studies have demonstrated that secretory proteins synthesized on ribosomes are transported by the rough ER to the Golgi complex where they are concentrated into secretory granules. During active secretion, secretory granules fuse with the cell membrane, liberating and discharging their contents into the perivascular spaces. When secretory activity is suppressed in anterior pituitary cells, undischarged secretory granules may be degraded by lysosomes. In the parathyroid gland, evidence indicates that the level of blood Ca ions regulates both the production and release of parathormone. Thus, when serum Ca is low, synthesis and release of parathormone are both stimulated; when serum Ca is elevated, these processes are inhibited.

Advance in genome analysis for human diseases

2009 ◽  
Vol 22 (2) ◽  
pp. 126-130
Author(s):  
Naomichi Matsumoto
Keyword(s):  
Genome Analysis ◽  
Human Diseases

Genome analysis of Lactobacillus sakei 23K: toward new biological and genetic studies of the species

2002 ◽  
Vol 22 (1-2) ◽  
pp. 55-58 ◽  
Author(s):  
Stéphane Chaillou ◽  
Anne-Marie Dudez ◽  
Monique Zagorec
Keyword(s):  
Genome Analysis ◽  
Lactobacillus Sakei ◽  
Genetic Studies
Sign in / Sign up

Export Citation Format

Share Document