scholarly journals Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Jiali Wan ◽  
Jia-Hong Wang ◽  
Ting Liu ◽  
Zhixiong Xie ◽  
Xue-Feng Yu ◽  
...  
Keyword(s):  
Aspect Ratio ◽  
Surface Chemistry ◽  
Gold Nanorods ◽  
Biological Toxicity

Polymeric/Inorganic Multifunctional Nanoparticles for Simultaneous Drug Delivery and Visualization

2010 ◽  
Vol 1257 ◽  
Author(s):  
Andrea Fornara ◽  
Alberto Recalenda ◽  
Jian Qin ◽  
Abhilash Sugunan ◽  
Fei Ye ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluorescence Microscopy ◽  
Contrast Agents ◽  
Gold Nanorods ◽  
In Vitro Cytotoxicity ◽  
In Vivo Studies ◽  
Multifunctional Nanoparticles ◽  
Cytotoxicity Studies

AbstractNanoparticles consisting of different biocompatible materials are attracting a lot of interest in the biomedical area as useful tools for drug delivery, photo-therapy and contrast enhancement agents in MRI, fluorescence and confocal microscopy. This work mainly focuses on the synthesis of polymeric/inorganic multifunctional nanoparticles (PIMN) based on biocompatible di-block copolymer poly(L,L-lactide-co-ethylene glycol) (PLLA-PEG) via an emulsion-evaporation method. Besides containing a hydrophobic drug (Indomethacin), these polymeric nanoparticles incorporate different visualization agents such as superparamagnetic iron oxide nanoparticles (SPION) and fluorescent Quantum Dots (QDs) that are used as contrast agents for Magnetic Resonance Imaging (MRI) and fluorescence microscopy together. Gold Nanorods are also incorporated in such nanostructures to allow simultaneous visualization and photodynamic therapy. MRI studies are performed with different loading of SPION into PIMN, showing an enhancement in T2 contrast superior to commercial contrast agents. Core-shell QDs absorption and emission spectra are recorded before and after their loading into PIMN. With these polymeric/inorganic multifunctional nanoparticles, both MRI visualization and confocal fluorescence microscopy studies can be performed. Gold nanorods are also synthesized and incorporated into PIMN without changing their longitudinal absorption peak usable for lased excitation and phototherapy. In-vitro cytotoxicity studies have also been performed to confirm the low cytotoxicity of PIMN for further in-vivo studies.

In vitro and in vivo studies on laser-activated gold nanorods for applications in photothermal therapies

2010 ◽  
Author(s):  
Roberto Pini ◽  
Fulvio Ratto ◽  
Paolo Matteini ◽  
Sonia Centi ◽  
Francesca Rossi
Keyword(s):  
Gold Nanorods ◽  
In Vivo Studies

scholarly journals Photothermolysis mediated by gold nanorods modified with EGFR monoclonal antibody induces Hep-2 cells apoptosis in vitro and in vivo

2014 ◽  
pp. 1931 ◽  
Author(s):  
Li Yunlong ◽  
Shiwen Zhang ◽  
Shouan Dong ◽  
Yunchao Huang ◽  
Xiaojiang Li ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Gold Nanorods

scholarly journals FORMULATION AND EVALUATION OF BUDESONIDE PELLETS CONTAINING NATURAL GUMS FOR COLON TARGETING

2021 ◽  
Vol 10 (3) ◽  
pp. 2825-2831
Author(s):  
Rijawan Rajjak Pathan
Keyword(s):  
Aspect Ratio ◽  
Physical Properties ◽  
Flow Behavior ◽  
In Vitro Release ◽  
Solvent Mixture ◽  
Cyamopsis Tetragonolobus ◽  
Vitro Release ◽  
Natural Gum

Pellets formulation with natural gums. The formulation of an enzyme as well as pH dependant pellets containing natural gums such as Mornings oleifera gum Lam. (MOG) and Cyamopsis tetragonolobus gum Taub. (CTG) were used for enzyme dependant release and further coating is provided to shows colon-specific delivery. Extrusion and spheronization techniques were used for the preparation of pellets. Pellets of budesonide evaluated for various properties such as flow behavior, physical properties such as sphericity, roundness, aspect ratio, hardness, and friability also investigated in vitro and in vivo targeting in rabbit. Preparation of pellets was done by using extrusion and spheronization method with the use of optimized concentration of gums those were 7.5% and 10% for CTG and MOG respectively and proportion of solvent mixture of water and Isopropyl alcohol in the ratio of 80:20. Pellets of budesonide evaluated for various properties includes flow behavior, physical properties such as sphericity, roundness, aspect ratio, hardness, and friability and found that all properties as per official limit also in vitro release study found that release of uncoated pellets in a sustained manner in 0.1N HCl for 2h due to swelling of natural gum, therefore further step of the coating was done in fluidized bed coater to prevent the release of drug in the upper part of GIT and after coating found that In vitro release of drug at the colonic environment and it confirmed with in vivo investigation in rabbit with X-ray examination of targeting and found that pellets reach at colonic part without disintegration. The use of natural gums for preparation of pellets in optimized concentration and wetting agent produce a formulation with all required chemical and physical properties and it gives effective in vitro release and also shows In vivo targeting in rabbit and due to use of natural gum for preparation of pellets also reduce some problems of metabolism of synthetic excipients.

Selective laser sintered nano-HA/PDLLA composite microspheres for bone scaffolds applications

2020 ◽  
Vol 26 (6) ◽  
pp. 1131-1143 ◽  
Author(s):  
Kesheng Lin ◽  
Jie Liu ◽  
Jia-Min Wu ◽  
Yunlong Sun ◽  
Feng Li ◽  
...  
Keyword(s):  
Degradation Rate ◽  
Orthogonal Experiment ◽  
Aseptic Inflammation ◽  
Content Type ◽  
Bone Scaffolds ◽  
Biological Toxicity ◽  
Composite Microspheres ◽  
Significant Difference

Purpose The main cause of aseptic inflammation after an in vivo implantation is that Poly(L-lactide) (PLLA) and Poly(D-lactide) have a slower degradation and absorption rate, while Poly(D, L-lactide) (PDLLA) has a much faster degradation rate than PLLA because of its amorphous structure. Also, the hydrolyzate of Hydroxyapatite (HA) is alkaline, which can neutralize local tissue peracid caused by hydrolysis of Polylactic acid. Design/methodology/approach In this study, the selective laser sintering (SLS) technique was chosen to prepare bone scaffolds using nano-HA/PDLLA composite microspheres, which were prepared by the solid-in-oil-in-water (S/O/W) method. First, the SLS parameters range of bulk was determined by the result of a single-layer experiment and the optimized parameters were then obtained by the orthogonal experiment. The tensile property, hydrophobicity, biocompatibility, biological toxicity and in vitro degradation of the samples with optimized SLS parameters were characterized. Findings As a result, the samples showed a lower tensile strength because of the many holes in their interior, which was conducive to better cell adhesion and nutrient transport. In addition, the samples retained their inherent properties after SLS and the hydrophobicity was improved after adding nano-HA because of the OH group. Furthermore, the samples showed good biocompatibility with the large number of cells adhering to the material through pseudopods and there was no significant difference between the pure PDLLA and 10% HA/PDLLA in terms of biological toxicity. Finally, the degradation rate of the composites could be tailored by the amount of nano-HA. Originality/value This study combined the S/O/W and SLS technique and provides a theoretical future basis for the preparation of drug-loaded microsphere scaffolds through SLS using HA/PDLLA composites.

The influence of shape and sliding distance of femoral head movement loci on the wear of acetabular cups in total hip arthroplasty

2002 ◽  
Vol 216 (6) ◽  
pp. 393-402 ◽  
Author(s):  
D Bennett ◽  
J F Orr ◽  
D E Beverland ◽  
R Baker
Keyword(s):  
Femoral Head ◽  
Aspect Ratio ◽  
Hip Joint ◽  
Wear Rates ◽  
Total Hip ◽  
Aspect Ratios ◽  
Average Aspect Ratio ◽  
Sliding Distance

Wear of the polyethylene acetabular component is the most serious threat to the long-term success of total hip replacements (THRs). Greatly reduced wear rates have been reported for unidirectional, compared to multidirectional, articulation in vitro. This study considers the multidirectional motions experienced at the hip joint as described by movement loci of points on the femoral head for individual THR patients. A three-dimensional computer program determined the movement loci of selected points on the femoral head for THR patients and normal subjects using kinematic data obtained from gait analysis. The sizes and shapes of these loci were quantified by their sliding distances and aspect ratios with substantial differences exhibited between individual THR patients. The average sliding distances ranged from 10.0 to 18.1 mm and the average aspect ratios of the loci ranged from 2.5 to 9.2 for the THR patients. Positive correlations were found between wear rate and average sliding distance, the inverse of the average aspect ratio of the loci and the product of the average sliding distance and the inverse of the average aspect ratio of the loci. Patients with a normal hip joint range of motion produce multidirectional motion loci and tend to experience more wear than patients with more unidirectional motion loci. Differing patterns of multidirectional motion at the hip joint for individual THR patients may explain widely differing wear rates in vivo.

scholarly journals Plasmonic photothermal cancer therapy with gold nanorods/reduced graphene oxide core/shell nanocomposites

RSC Advances ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. 1600-1610 ◽  
Author(s):  
Kostiantyn Turcheniuk ◽  
Tetiana Dumych ◽  
Rostyslav Bilyy ◽  
Volodymyr Turcheniuk ◽  
Julie Bouckaert ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Cancer Therapy ◽  
Reduced Graphene Oxide ◽  
Photon Energy ◽  
Gold Nanorods ◽  
Core Shell ◽  
Efficient Conversion ◽  
Reduced Graphene

Gold nanorods (Au NRs) are known for their efficient conversion of photon energy into heat, resulting in hyperthermia and suppression of tumor growths in vitro and in vivo.

The aspect ratio effect of drug nanocrystals on cellular internalization efficiency, uptake mechanisms, and in vitro and in vivo anticancer efficiencies

Nanoscale ◽  
2015 ◽  
Vol 7 (8) ◽  
pp. 3588-3593 ◽  
Author(s):  
Baishun Tian ◽  
Xiujuan Zhang ◽  
Caitong Yu ◽  
Mengjiao Zhou ◽  
Xiaohong Zhang
Keyword(s):  
Aspect Ratio ◽  
Cellular Internalization ◽  
Ratio Effect ◽  
Uptake Mechanisms

The aspect ratio effect of drug nanocrystals on their in vitro cellular internalizing efficiency and in vivo antitumor efficiency was investigated.

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