scholarly journals A cost-effective and efficient reprogramming platform for large-scale production of integration-free human induced pluripotent stem cells in chemically defined culture

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Jeanette Beers ◽  
Kaari L. Linask ◽  
Jane A. Chen ◽  
Lauren I. Siniscalchi ◽  
Yongshun Lin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Large Scale ◽  
Cost Effective ◽  
Scale Production ◽  
Large Scale Production ◽  
Induced Pluripotent ◽  
Defined Culture

scholarly journals Derivation of Transgene-Free Human Induced Pluripotent Stem Cells from Human Peripheral T Cells in Defined Culture Conditions

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97397 ◽  
Author(s):  
Yoshikazu Kishino ◽  
Tomohisa Seki ◽  
Jun Fujita ◽  
Shinsuke Yuasa ◽  
Shugo Tohyama ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Culture Conditions ◽  
Peripheral T Cells ◽  
Induced Pluripotent ◽  
Defined Culture

scholarly journals Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression

2012 ◽  
Vol 30 (12) ◽  
pp. 1244-1248 ◽  
Author(s):  
Gabsang Lee ◽  
Christina N Ramirez ◽  
Hyesoo Kim ◽  
Nadja Zeltner ◽  
Becky Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Large Scale ◽  
Familial Dysautonomia ◽  
Induced Pluripotent ◽  
Large Scale Screening

scholarly journals Building Multi-Dimensional Induced Pluripotent Stem Cells-Based Model Platforms to Assess Cardiotoxicity in Cancer Therapies

2021 ◽  
Vol 12 ◽  
Author(s):  
Dilip Thomas ◽  
Sushma Shenoy ◽  
Nazish Sayed
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Safety Evaluation ◽  
Cost Effective ◽  
Patient Specific ◽  
Cancer Therapies ◽  
Cardiovascular Risks ◽  
Cardiovascular Cells ◽  
Induced Pluripotent

Cardiovascular disease (CVD) complications have contributed significantly toward poor survival of cancer patients worldwide. These complications that result in myocardial and vascular damage lead to long-term multisystemic disorders. In some patient cohorts, the progression from acute to symptomatic CVD state may be accelerated due to exacerbation of underlying comorbidities such as obesity, diabetes and hypertension. In such situations, cardio-oncologists are often left with a clinical predicament in finding the optimal therapeutic balance to minimize cardiovascular risks and maximize the benefits in treating cancer. Hence, prognostically there is an urgent need for cost-effective, rapid, sensitive and patient-specific screening platform to allow risk-adapted decision making to prevent cancer therapy related cardiotoxicity. In recent years, momentous progress has been made toward the successful derivation of human cardiovascular cells from induced pluripotent stem cells (iPSCs). This technology has not only provided deeper mechanistic insights into basic cardiovascular biology but has also seamlessly integrated within the drug screening and discovery programs for early efficacy and safety evaluation. In this review, we discuss how iPSC-derived cardiovascular cells have been utilized for testing oncotherapeutics to pre-determine patient predisposition to cardiovascular toxicity. Lastly, we highlight the convergence of tissue engineering technologies and precision medicine that can enable patient-specific cardiotoxicity prognosis and treatment on a multi-organ level.

Stability of human induced pluripotent stem cells cultured in a xeno-free and defined culture medium, Stemfit®

Cytotherapy ◽  
2017 ◽  
Vol 19 (5) ◽  
pp. S189-S190
Author(s):  
H. Ozawa ◽  
T. Matsumoto ◽  
A. Evyryanti ◽  
J. Chang ◽  
I. Harata ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Culture Medium ◽  
Induced Pluripotent ◽  
Defined Culture ◽  
Cells Cultured
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