scholarly journals Antioxidant treatment enhances human mesenchymal stem cell anti-stress ability and therapeutic efficacy in an acute liver failure model

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Wen Zeng ◽  
Jia Xiao ◽  
Gang Zheng ◽  
Feiyue Xing ◽  
George L. Tipoe ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Therapeutic Efficacy ◽  
Human Mesenchymal Stem Cell ◽  
Failure Model ◽  
Antioxidant Treatment

FRI-086-Stem cell treatment on acute liver failure model using semipermeable Poly Lactic-co-Glycolic Acid membrane pouch

2019 ◽  
Vol 70 (1) ◽  
pp. e422 ◽  
Author(s):  
Bo-Kyeong Kang ◽  
Mi Mi Kim ◽  
Dae Won JUN ◽  
Jinhwa Park ◽  
Jaeyoon Jeong ◽  
...  
Keyword(s):  
Stem Cell ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Glycolic Acid ◽  
Failure Model ◽  
Stem Cell Treatment

scholarly journals Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure

ACS Nano ◽  
2018 ◽  
Vol 12 (7) ◽  
pp. 6536-6544 ◽  
Author(s):  
Hongxia Liang ◽  
Ke Huang ◽  
Teng Su ◽  
Zhenhua Li ◽  
Shiqi Hu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Carbon Tetrachloride ◽  
Mesenchymal Stem Cell ◽  
Blood Cell ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Red Blood Cell

scholarly journals Hepatocyte and mesenchymal stem cell co-transplantation in rats with acute liver failure

2020 ◽  
Vol 34 (2) ◽  
pp. 100-108
Author(s):  
Cheng-Maw Ho ◽  
Ya-Hui Chen ◽  
Chin-Sung Chien ◽  
Shu-Li Ho ◽  
Hui-Ling Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Liver Failure ◽  
Acute Liver Failure

Attenuation of Postoperative Acute Liver Failure by Mesenchymal Stem Cell Treatment Due to Metabolic Implications

2016 ◽  
Vol 263 (3) ◽  
pp. 546-556 ◽  
Author(s):  
Hans-Michael Tautenhahn ◽  
Sandra Brückner ◽  
Sven Baumann ◽  
Sandra Winkler ◽  
Wolfgang Otto ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment

Effect of Stem Cell Treatment on Acute Liver Failure Model Using Scaffold

2018 ◽  
Vol 64 (3) ◽  
pp. 781-791
Author(s):  
Hyeon Tae Kang ◽  
Dae Won Jun ◽  
Kiseok Jang ◽  
Jeong-Kyu Hoh ◽  
Jai Sun Lee ◽  
...  
Keyword(s):  
Stem Cell ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Failure Model ◽  
Stem Cell Treatment

scholarly journals Application of mesenchymal stem cell exosomes and their drug‐loading systems in acute liver failure

2020 ◽  
Vol 24 (13) ◽  
pp. 7082-7093 ◽  
Author(s):  
Shuqin Zhang ◽  
Yu Hou ◽  
Jing Yang ◽  
Denghui Xie ◽  
Linrui Jiang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Drug Loading

scholarly journals Magnetic targeting enhances the cutaneous wound healing effects of human mesenchymal stem cell-derived iron oxide exosomes

2020 ◽  
Author(s):  
Xiuying Li ◽  
Ying Wang ◽  
Liyan Shi ◽  
Binxi Li ◽  
Jing Li ◽  
...  
Keyword(s):  
Stem Cell ◽  
Iron Oxide ◽  
Mesenchymal Stem Cell ◽  
Therapeutic Efficacy ◽  
Human Mesenchymal Stem Cell ◽  
Endothelial Cell Proliferation ◽  
Iron Oxide Nanoparticle ◽  
Systemic Injection ◽  
Cutaneous Wound

Abstract Human mesenchymal stem cell (MSC)-derived exosomes (Exos) are a promising therapeutic agent for cell-free regenerative medicine. However, their poor organ-targeting ability and therapeutic efficacy have been found to critically limit their clinical applications. In the present study, we fabricated iron oxide nanoparticle (NP)-labeled exosomes (Exo+NPs) from NP-treated MSCs and evaluated their therapeutic efficacy in a clinically relevant model of skin injury. We found that the Exos could be readily internalized by human umbilical vein endothelial cells (HUVECs), and could significantly promote their proliferation, migration, and angiogenesis both in vitro and in vivo. Moreover, the protein expression of proliferative markers (Cyclin D1 and Cyclin A2), growth factors (VEGFA), and migration-related chemokines (CXCL12) was significantly upregulated after Exo treatment. Unlike the Exos prepared from untreated MSCs, the Exo+NPs contained NPs that acted as a magnet-guided navigation tool. The in vivo systemic injection of Exo+NPs with magnetic guidance significantly increased the number of Exo+NPs that accumulated at the injury site. Furthermore, these accumulated Exo+NPs significantly enhanced endothelial cell proliferation, migration, and angiogenic tubule formation in vivo; moreover, they reduced scar formation and increased CK19, PCNA, and collagen expression in vivo. Collectively, these findings confirm the development of therapeutically efficacious extracellular nanovesicles and demonstrate their feasibility in cutaneous wound repair.

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